scholarly journals Heterogeneous Nuclear Ribonucleoprotein K Modulates Angiotensinogen Gene Expression in Kidney Cells

2006 ◽  
Vol 281 (35) ◽  
pp. 25344-25355 ◽  
Author(s):  
Chih-Chang Wei ◽  
Shao-Ling Zhang ◽  
Yun-Wen Chen ◽  
Deng-Fu Guo ◽  
Julie R. Ingelfinger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Kidney Cells ◽  
Angiotensinogen Gene ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Nuclear Ribonucleoprotein

scholarly journals Requirement of Heterogeneous Nuclear Ribonucleoprotein C for BRCA Gene Expression and Homologous Recombination

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e61368 ◽  
Author(s):  
Rachel W. Anantha ◽  
Allen L. Alcivar ◽  
Jianglin Ma ◽  
Hong Cai ◽  
Srilatha Simhadri ◽  
...  
Keyword(s):  
Gene Expression ◽  
Homologous Recombination ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Brca Gene ◽  
Nuclear Ribonucleoprotein

scholarly journals Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia

2017 ◽  
Vol 37 (11) ◽  
pp. 2182-2194 ◽  
Author(s):  
Li Zhang ◽  
Qishan Chen ◽  
Weiwei An ◽  
Feng Yang ◽  
Eithne Margaret Maguire ◽  
...  
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Expression Levels ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Atherosclerotic Lesions ◽  
Nuclear Ribonucleoprotein

Objective— hnRNPA1 (heterogeneous nuclear ribonucleoprotein A1) plays a variety of roles in gene expression. However, little is known about the functional involvement of hnRNPA1 in vascular smooth muscle cell (VSMC) function and neointima hyperplasia. In this study, we have attempted to investigate the functional roles of hnRNPA1 in the contexts of VSMC function, injury-induced vessel remodeling, and human atherosclerotic lesions, as well as discern the molecular mechanisms involved. Approach and Results— hnRNPA1 expression levels were consistently modulated during VSMC phenotype switching and neointimal lesion formation induced by wire injury. Functional studies showed that VSMC-specific gene expression, proliferation, and migration were regulated by hnRNPA1. Our data show that hnRNPA1 exerts its effects on VSMC functions through modulation of IQGAP1 (IQ motif containing GTPase activating protein 1). Mechanistically, hnRNPA1 regulates IQGAP1 mRNA degradation through 2 mechanisms: upregulating microRNA-124 (miR-124) and binding to AU-rich element of IQGAP1 gene. Further evidence suggests that hnRNPA1 upregulates miR-124 by modulating miR-124 biogenesis and that IQGAP1 is the authentic target gene of miR-124. Importantly, ectopic overexpression of hnRNPA1 greatly reduced VSMC proliferation and inhibited neointima formation in wire-injured carotid arteries. Finally, lower expression levels of hnRNPA1 and miR-124, while higher expression levels of IQGAP1, were observed in human atherosclerotic lesions. Conclusions— Our data show that hnRNPA1 is a critical regulator of VSMC function and behavior in the context of neointima hyperplasia, and the hnRNPA1/miR-124/IQGAP1 regulatory axis represents a novel therapeutic target for the prevention of cardiovascular diseases.

scholarly journals A+U-rich-element RNA-binding factor 1/heterogeneous nuclear ribonucleoprotein D gene expression is regulated by oestrogen in the rat uterus

2002 ◽  
Vol 361 (1) ◽  
pp. 125 ◽  
Author(s):  
Yukitomo ARAO ◽  
Atsumi KIKUCHI ◽  
Kazuhiro IKEDA ◽  
Satoshi NOMOTO ◽  
Hyogo HORIGUCHI ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rna Binding ◽  
Rat Uterus ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Binding Factor ◽  
Nuclear Ribonucleoprotein

scholarly journals Gene Expression Changes Associated with the Loss of Heterogeneous Nuclear Ribonucleoprotein M Function

2017 ◽  
Vol 07 (02) ◽  
pp. 87-98 ◽  
Author(s):  
Jun-ichi Takino ◽  
Kentaro Nagamine ◽  
Mikoto Suzuki ◽  
Akiko Sakasai-Sakai ◽  
Masayoshi Takeuchi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Nuclear Ribonucleoprotein

scholarly journals Transcriptional regulation of heterogeneous nuclear ribonucleoprotein K gene expression

Biochimie ◽  
2015 ◽  
Vol 109 ◽  
pp. 27-35 ◽  
Author(s):  
Liqing He ◽  
Xiaochang Xue ◽  
Zhengjun Wang ◽  
Entai Hou ◽  
Yong Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Nuclear Ribonucleoprotein

scholarly journals Alpha-adrenoceptors and angiotensinogen gene expression in opossum kidney cells

1995 ◽  
Vol 48 (1) ◽  
pp. 139-145 ◽  
Author(s):  
Tian-Tian Wang ◽  
Silvana Lachance ◽  
Aline Delalandre ◽  
Serge Carrière ◽  
John S.D. Chan
Keyword(s):  
Gene Expression ◽  
Kidney Cells ◽  
Opossum Kidney ◽  
Alpha Adrenoceptors ◽  
Angiotensinogen Gene ◽  
Opossum Kidney Cells
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