scholarly journals Gene Expression Changes Associated with the Loss of Heterogeneous Nuclear Ribonucleoprotein M Function

2017 ◽  
Vol 07 (02) ◽  
pp. 87-98 ◽  
Author(s):  
Jun-ichi Takino ◽  
Kentaro Nagamine ◽  
Mikoto Suzuki ◽  
Akiko Sakasai-Sakai ◽  
Masayoshi Takeuchi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Nuclear Ribonucleoprotein

scholarly journals Requirement of Heterogeneous Nuclear Ribonucleoprotein C for BRCA Gene Expression and Homologous Recombination

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e61368 ◽  
Author(s):  
Rachel W. Anantha ◽  
Allen L. Alcivar ◽  
Jianglin Ma ◽  
Hong Cai ◽  
Srilatha Simhadri ◽  
...  
Keyword(s):  
Gene Expression ◽  
Homologous Recombination ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Brca Gene ◽  
Nuclear Ribonucleoprotein

scholarly journals Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia

2017 ◽  
Vol 37 (11) ◽  
pp. 2182-2194 ◽  
Author(s):  
Li Zhang ◽  
Qishan Chen ◽  
Weiwei An ◽  
Feng Yang ◽  
Eithne Margaret Maguire ◽  
...  
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Expression Levels ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Atherosclerotic Lesions ◽  
Nuclear Ribonucleoprotein

Objective— hnRNPA1 (heterogeneous nuclear ribonucleoprotein A1) plays a variety of roles in gene expression. However, little is known about the functional involvement of hnRNPA1 in vascular smooth muscle cell (VSMC) function and neointima hyperplasia. In this study, we have attempted to investigate the functional roles of hnRNPA1 in the contexts of VSMC function, injury-induced vessel remodeling, and human atherosclerotic lesions, as well as discern the molecular mechanisms involved. Approach and Results— hnRNPA1 expression levels were consistently modulated during VSMC phenotype switching and neointimal lesion formation induced by wire injury. Functional studies showed that VSMC-specific gene expression, proliferation, and migration were regulated by hnRNPA1. Our data show that hnRNPA1 exerts its effects on VSMC functions through modulation of IQGAP1 (IQ motif containing GTPase activating protein 1). Mechanistically, hnRNPA1 regulates IQGAP1 mRNA degradation through 2 mechanisms: upregulating microRNA-124 (miR-124) and binding to AU-rich element of IQGAP1 gene. Further evidence suggests that hnRNPA1 upregulates miR-124 by modulating miR-124 biogenesis and that IQGAP1 is the authentic target gene of miR-124. Importantly, ectopic overexpression of hnRNPA1 greatly reduced VSMC proliferation and inhibited neointima formation in wire-injured carotid arteries. Finally, lower expression levels of hnRNPA1 and miR-124, while higher expression levels of IQGAP1, were observed in human atherosclerotic lesions. Conclusions— Our data show that hnRNPA1 is a critical regulator of VSMC function and behavior in the context of neointima hyperplasia, and the hnRNPA1/miR-124/IQGAP1 regulatory axis represents a novel therapeutic target for the prevention of cardiovascular diseases.

scholarly journals A+U-rich-element RNA-binding factor 1/heterogeneous nuclear ribonucleoprotein D gene expression is regulated by oestrogen in the rat uterus

2002 ◽  
Vol 361 (1) ◽  
pp. 125 ◽  
Author(s):  
Yukitomo ARAO ◽  
Atsumi KIKUCHI ◽  
Kazuhiro IKEDA ◽  
Satoshi NOMOTO ◽  
Hyogo HORIGUCHI ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rna Binding ◽  
Rat Uterus ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Binding Factor ◽  
Nuclear Ribonucleoprotein

scholarly journals Transcriptional regulation of heterogeneous nuclear ribonucleoprotein K gene expression

Biochimie ◽  
2015 ◽  
Vol 109 ◽  
pp. 27-35 ◽  
Author(s):  
Liqing He ◽  
Xiaochang Xue ◽  
Zhengjun Wang ◽  
Entai Hou ◽  
Yong Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Nuclear Ribonucleoprotein

scholarly journals Heterogeneous Nuclear Ribonucleoprotein K Modulates Angiotensinogen Gene Expression in Kidney Cells

2006 ◽  
Vol 281 (35) ◽  
pp. 25344-25355 ◽  
Author(s):  
Chih-Chang Wei ◽  
Shao-Ling Zhang ◽  
Yun-Wen Chen ◽  
Deng-Fu Guo ◽  
Julie R. Ingelfinger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Kidney Cells ◽  
Angiotensinogen Gene ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Nuclear Ribonucleoprotein

scholarly journals Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice

Endocrinology ◽  
2017 ◽  
Vol 158 (4) ◽  
pp. 903-919 ◽  
Author(s):  
Anindya Ghosh ◽  
Shaaban Abdo ◽  
Shuiling Zhao ◽  
Chin-Han Wu ◽  
Yixuan Shi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Diabetic Mice ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Nuclear Ribonucleoprotein ◽  
Heterogeneous Nuclear Ribonucleoprotein F

scholarly journals Identification of TINO

2004 ◽  
Vol 279 (19) ◽  
pp. 20154-20166 ◽  
Author(s):  
Martino Donnini ◽  
Andrea Lapucci ◽  
Laura Papucci ◽  
Ewa Witort ◽  
Alain Jacquier ◽  
...  
Keyword(s):  
Gene Expression ◽  
Binding Proteins ◽  
Nucleic Acid Binding ◽  
Cis Acting ◽  
Ciona Savignyi ◽  
Amino Terminal ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Gene Expression Control ◽  
Nuclear Ribonucleoprotein ◽  
Mrna Binding

Modulation of mRNA stability by regulatory cis-acting AU-rich elements (AREs) and ARE-binding proteins is an important posttranscriptional mechanism of gene expression control. We previously demonstrated that the 3′-untranslated region ofBCL-2mRNA contains an ARE that accounts for rapidBCL-2down-regulation in response to apoptotic stimuli. We also demonstrated that theBCL-2ARE core interacts with a number of ARE-binding proteins, one of which is AU-rich factor 1/heterogeneous nuclear ribonucleoprotein D, known for its interaction with mRNA elements of others genes. In an attempt to search for otherBCL-2mRNA-binding proteins, we used the yeast RNA three-hybrid system assay and identified a novel human protein that interacts withBCL-2ARE. We refer to it as TINO. The predicted protein sequence of TINO reveals two amino-terminal heterogeneous nuclear ribonucleoprotein K homology motifs for nucleic acid binding and a carboxyl-terminal RING domain, endowed with a putative E3 ubiquitin-protein ligase activity. In addition the novel protein is evolutionarily conserved; the two following orthologous proteins have been identified with protein-protein BLAST: posterior end mark-3 (PEM-3) ofCiona savignyiand muscle excess protein-3 (MEX-3) ofCaenorhabditis elegans. Upon binding, TINO destabilizes a chimeric reporter construct containing theBCL-2ARE sequence, revealing a negative regulatory action onBCL-2gene expression at the posttranscriptional level.

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