scholarly journals Isolation and Functional Characterization of a Novel Organic Solute Carrier Protein, hOSCP1

2005 ◽  
Vol 280 (37) ◽  
pp. 32332-32339 ◽  
Author(s):  
Yasuna Kobayashi ◽  
Akiko Shibusawa ◽  
Hironori Saito ◽  
Naomi Ohshiro ◽  
Masayuki Ohbayashi ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Carrier Protein ◽  
Organic Solute ◽  
Solute Carrier

Isolation and Characterization of Polyspecific Mouse Organic Solute Carrier Protein 1 (mOscp1)

2007 ◽  
Vol 35 (7) ◽  
pp. 1239-1245 ◽  
Author(s):  
Yasuna Kobayashi ◽  
Ayumi Tsuchiya ◽  
Tomofumi Hayashi ◽  
Noriko Kohyama ◽  
Masayuki Ohbayashi ◽  
...  
Keyword(s):  
Carrier Protein ◽  
Isolation And Characterization ◽  
Organic Solute ◽  
Solute Carrier

scholarly journals Functional Characterization of a Na+-Coupled Dicarboxylate Carrier Protein from Staphylococcus aureus

2005 ◽  
Vol 187 (15) ◽  
pp. 5189-5194 ◽  
Author(s):  
Jason A. Hall ◽  
Ana M. Pajor
Keyword(s):  
Staphylococcus Aureus ◽  
Structural Analysis ◽  
Transport Properties ◽  
Sequence Homology ◽  
Cytoplasmic Membrane ◽  
Functional Characterization ◽  
Carrier Protein ◽  
Dependent Manner ◽  
Reaction Sequence

ABSTRACT We have cloned and functionally characterized a Na+-coupled dicarboxylate transporter, SdcS, from Staphylococcus aureus. This carrier protein is a member of the divalent anion/Na+ symporter (DASS) family and shares significant sequence homology with the mammalian Na+/dicarboxylate cotransporters NaDC-1 and NaDC-3. Analysis of SdcS function indicates transport properties consistent with those of its eukaryotic counterparts. Thus, SdcS facilitates the transport of the dicarboxylates fumarate, malate, and succinate across the cytoplasmic membrane in a Na+-dependent manner. Furthermore, kinetic work predicts an ordered reaction sequence with Na+ (K 0.5 of 2.7 mM) binding before dicarboxylate (Km of 4.5 μM). Because this transporter and its mammalian homologs are functionally similar, we suggest that SdcS may serve as a useful model for DASS family structural analysis.

Identification and functional characterization of solute carrier family 6 genes in Ciona savignyi

Gene ◽  
2019 ◽  
Vol 705 ◽  
pp. 142-148
Author(s):  
Ping Ren ◽  
Jiankai Wei ◽  
Haiyan Yu ◽  
Bo Dong
Keyword(s):  
Functional Characterization ◽  
Solute Carrier Family ◽  
Ciona Savignyi ◽  
Solute Carrier
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