Structural and functional characterization of the bovine solute carrier family 27 member 1 (SLC27A1) gene

2006 ◽  
Vol 115 (2) ◽  
pp. 115-122 ◽  
Author(s):  
L. Ordovás ◽  
R. Roy ◽  
P. Zaragoza ◽  
C. Rodellar
Keyword(s):  
Functional Characterization ◽  
Solute Carrier Family ◽  
Solute Carrier ◽  
I Gene

Identification and functional characterization of solute carrier family 6 genes in Ciona savignyi

Gene ◽  
2019 ◽  
Vol 705 ◽  
pp. 142-148
Author(s):  
Ping Ren ◽  
Jiankai Wei ◽  
Haiyan Yu ◽  
Bo Dong
Keyword(s):  
Functional Characterization ◽  
Solute Carrier Family ◽  
Ciona Savignyi ◽  
Solute Carrier

Identification and functional characterization of a solute carrier family 15, member 4 gene in Litopenaeus vannamei

2016 ◽  
Vol 57 ◽  
pp. 57-66 ◽  
Author(s):  
Yong-Gui Chen ◽  
Kai Yuan ◽  
Ze-Zhi Zhang ◽  
Feng-Hua Yuan ◽  
Shao-Ping Weng ◽  
...  
Keyword(s):  
Litopenaeus Vannamei ◽  
Functional Characterization ◽  
Solute Carrier Family ◽  
Solute Carrier

scholarly journals Functional characterization of the cis-regulatory elements of the rat ribophorin I gene

1995 ◽  
Vol 23 (3) ◽  
pp. 313-319 ◽  
Author(s):  
Ayyappan K. Rajasekaran ◽  
Zhongmin Zhou ◽  
Kulkarni Prakash ◽  
Gokul Das ◽  
Gert Kreibich
Keyword(s):  
Functional Characterization ◽  
Regulatory Elements ◽  
I Gene

The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+

2012 ◽  
Vol 443 (1) ◽  
pp. 241-247 ◽  
Author(s):  
Gennaro Agrimi ◽  
Annamaria Russo ◽  
Pasquale Scarcia ◽  
Ferdinando Palmieri
Keyword(s):  
Human Gene ◽  
Main Function ◽  
Human Tissues ◽  
Solute Carrier Family ◽  
Peroxisomal Membrane ◽  
Mitochondrial Carrier ◽  
Mitochondrial Carrier Family ◽  
Solute Carrier ◽  
Identification And Characterization

The essential cofactors CoA, FAD and NAD+ are synthesized outside the peroxisomes and therefore must be transported into the peroxisomal matrix where they are required for important processes. In the present study we have functionally identified and characterized SLC25A17 (solute carrier family 25 member 17), which is the only member of the mitochondrial carrier family that has previously been shown to be localized in the peroxisomal membrane. Recombinant and purified SLC25A17 was reconstituted into liposomes. Its transport properties and kinetic parameters demonstrate that SLC25A17 is a transporter of CoA, FAD, FMN and AMP, and to a lesser extent of NAD+, PAP (adenosine 3′,5′-diphosphate) and ADP. SLC25A17 functioned almost exclusively by a counter-exchange mechanism, was saturable and was inhibited by pyridoxal 5′-phosphate and other mitochondrial carrier inhibitors. It was expressed to various degrees in all of the human tissues examined. Its main function is probably to transport free CoA, FAD and NAD+ into peroxisomes in exchange for intraperoxisomally generated PAP, FMN and AMP. The present paper is the first report describing the identification and characterization of a transporter for multiple free cofactors in peroxisomes.

scholarly journals Isolation and Functional Characterization of a Novel Organic Solute Carrier Protein, hOSCP1

2005 ◽  
Vol 280 (37) ◽  
pp. 32332-32339 ◽  
Author(s):  
Yasuna Kobayashi ◽  
Akiko Shibusawa ◽  
Hironori Saito ◽  
Naomi Ohshiro ◽  
Masayuki Ohbayashi ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Carrier Protein ◽  
Organic Solute ◽  
Solute Carrier
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