scholarly journals 1-Methyl-4-phenylpyridinium-induced Apoptosis in Cerebellar Granule Neurons Is Mediated by Transferrin Receptor Iron-dependent Depletion of Tetrahydrobiopterin and Neuronal Nitric-oxide Synthase-derived Superoxide

2004 ◽  
Vol 279 (18) ◽  
pp. 19099-19112 ◽  
Author(s):  
Tiesong Shang ◽  
Srigiridhar Kotamraju ◽  
Shasi V. Kalivendi ◽  
Cecilia J. Hillard ◽  
B. Kalyanaraman
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Transferrin Receptor ◽  
Neuronal Nitric Oxide Synthase ◽  
Cerebellar Granule Neurons ◽  
Granule Neurons ◽  
Cerebellar Granule ◽  
Induced Apoptosis ◽  
Oxide Synthase

Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons

2014 ◽  
Vol 459 (2) ◽  
pp. 251-263 ◽  
Author(s):  
Shingo Kasamatsu ◽  
Yasuo Watanabe ◽  
Tomohiro Sawa ◽  
Takaaki Akaike ◽  
Hideshi Ihara
Keyword(s):  
Nitric Oxide ◽  
Neuronal Nitric Oxide Synthase ◽  
Cerebellar Granule Neurons ◽  
Ros Generation ◽  
Granule Neurons ◽  
Cerebellar Granule ◽  
Haem Oxygenase ◽  
Oxide Synthase ◽  
Signal Regulation ◽  
Generation Activity

Phosphorylation of neuronal nitric oxide synthase at Ser847 increased its ROS generation activity and changed the ratio of NO to ROS to regulate intracellular redox signalling, which is involved in neuroprotection against apoptosis via HO-1 (haem oxygenase 1) expression in cerebellar granule neurons.

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