Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons

Shingo Kasamatsu; Yasuo Watanabe; Tomohiro Sawa; Takaaki Akaike; Hideshi Ihara

doi:10.1042/bj20131262

Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons

Biochemical Journal ◽

10.1042/bj20131262 ◽

2014 ◽

Vol 459 (2) ◽

pp. 251-263 ◽

Cited By ~ 23

Author(s):

Shingo Kasamatsu ◽

Yasuo Watanabe ◽

Tomohiro Sawa ◽

Takaaki Akaike ◽

Hideshi Ihara

Keyword(s):

Nitric Oxide ◽

Neuronal Nitric Oxide Synthase ◽

Cerebellar Granule Neurons ◽

Ros Generation ◽

Granule Neurons ◽

Cerebellar Granule ◽

Haem Oxygenase ◽

Oxide Synthase ◽

Signal Regulation ◽

Generation Activity

Phosphorylation of neuronal nitric oxide synthase at Ser847 increased its ROS generation activity and changed the ratio of NO to ROS to regulate intracellular redox signalling, which is involved in neuroprotection against apoptosis via HO-1 (haem oxygenase 1) expression in cerebellar granule neurons.

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1-Methyl-4-phenylpyridinium-induced Apoptosis in Cerebellar Granule Neurons Is Mediated by Transferrin Receptor Iron-dependent Depletion of Tetrahydrobiopterin and Neuronal Nitric-oxide Synthase-derived Superoxide

Journal of Biological Chemistry ◽

10.1074/jbc.m400101200 ◽

2004 ◽

Vol 279 (18) ◽

pp. 19099-19112 ◽

Cited By ~ 54

Author(s):

Tiesong Shang ◽

Srigiridhar Kotamraju ◽

Shasi V. Kalivendi ◽

Cecilia J. Hillard ◽

B. Kalyanaraman

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Transferrin Receptor ◽

Neuronal Nitric Oxide Synthase ◽

Cerebellar Granule Neurons ◽

Granule Neurons ◽

Cerebellar Granule ◽

Induced Apoptosis ◽

Oxide Synthase

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Stimulation of the cAMP pathway protects cultured cerebellar granule neurons against alcohol-induced cell death by activating the neuronal nitric oxide synthase (nNOS) gene

Brain Research ◽

10.1016/j.brainres.2007.01.059 ◽

2007 ◽

Vol 1143 ◽

pp. 34-45 ◽

Cited By ~ 24

Author(s):

Bahri Karaçay ◽

Guiying Li ◽

Nicholas J. Pantazis ◽

Daniel J. Bonthius

Keyword(s):

Nitric Oxide ◽

Cell Death ◽

Nitric Oxide Synthase ◽

Neuronal Nitric Oxide Synthase ◽

Cerebellar Granule Neurons ◽

Granule Neurons ◽

Cerebellar Granule ◽

Camp Pathway ◽

Oxide Synthase ◽

Stimulation Of

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N-methyl-D-aspartate receptors, L-type voltage-operated calcium channels and neuronal nitric oxide synthase forms a calcium/redox nano-switch within lipid rafts in cerebellar granule neurons in culture

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2012.08.373 ◽

2012 ◽

Vol 53 ◽

pp. S177-S178

Author(s):

D. Marques-da-Silva⁎ ◽

C. Gutierrez-Merino

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Calcium Channels ◽

Lipid Rafts ◽

Neuronal Nitric Oxide Synthase ◽

Cerebellar Granule Neurons ◽

Granule Neurons ◽

Cerebellar Granule ◽

Oxide Synthase ◽

Voltage Operated Calcium Channels

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Knockdown of the neuronal nitric oxide synthase gene retard the development of the cerebellar granule neurons in vitro

Developmental Dynamics ◽

10.1002/dvdy.22189 ◽

2009 ◽

Vol 239 (2) ◽

pp. 474-481 ◽

Cited By ~ 10

Author(s):

Mei Li ◽

Lin Wang ◽

Ying Peng ◽

Jia-Chuan Wang ◽

Li-Hua Zhou

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Neuronal Nitric Oxide Synthase ◽

Cerebellar Granule Neurons ◽

Granule Neurons ◽

Cerebellar Granule ◽

Oxide Synthase

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Sequential activation of constitutive and inducible nitric oxide synthase (NOS) in rat cerebellar granule neurons by Pseudomonas fluorescens and invasive behaviour of the bacteria

Microbiological Research ◽

10.1016/j.micres.2004.08.003 ◽

2004 ◽

Vol 159 (4) ◽

pp. 355-363 ◽

Cited By ~ 7

Author(s):

S. Mezghani-Abdelmoula ◽

A. Khémiri ◽

O. Lesouhaitier ◽

S. Chevalier ◽

N. Orange ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Pseudomonas Fluorescens ◽

Inducible Nitric Oxide Synthase ◽

Cerebellar Granule Neurons ◽

Granule Neurons ◽

Cerebellar Granule ◽

Sequential Activation ◽

Oxide Synthase ◽

Inducible Nitric Oxide

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Nitric oxide synthase inhibitor decreases NMDA-induced elevations of extracellular glutamate and intracellular Ca2+ levels via a cGMP-independent mechanism in cerebellar granule neurons

Archives of Pharmacal Research ◽

10.1007/bf02976435 ◽

1999 ◽

Vol 22 (1) ◽

pp. 48-54 ◽

Cited By ~ 2

Author(s):

Seikwan Oh ◽

Bong-Sik Yun ◽

In-Ja Ryoo ◽

Patrick P. McCaslin ◽

Ick-Dong Yoo

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Cerebellar Granule Neurons ◽

Granule Neurons ◽

Extracellular Glutamate ◽

Nitric Oxide Synthase Inhibitor ◽

Cerebellar Granule ◽

Independent Mechanism ◽

Synthase Inhibitor ◽

Oxide Synthase

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Lipopolysaccharide-induced nitric oxide synthase activity in cultured cerebellar granule neurons

Neuroscience Letters ◽

10.1016/0304-3940(96)12377-6 ◽

1996 ◽

Vol 205 (1) ◽

pp. 45-48 ◽

Cited By ~ 10

Author(s):

Ikuko Sato ◽

Toshiyuki Himi ◽

Sei-itsu Murota

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Cerebellar Granule Neurons ◽

Granule Neurons ◽

Cerebellar Granule ◽

Oxide Synthase ◽

Nitric Oxide Synthase Activity

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Heregulin upregulates the expression of nitric oxide synthase (NOS)-1 in rat cerebellar granule neurons via the ErbB4 receptor

Journal of Neurochemistry ◽

10.1046/j.1471-4159.2001.00089.x ◽

2009 ◽

Vol 76 (1) ◽

pp. 312-315 ◽

Cited By ~ 11

Author(s):

Randy Krainock ◽

Sean Murphy

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Cerebellar Granule Neurons ◽

Granule Neurons ◽

Cerebellar Granule ◽

Erbb4 Receptor ◽

Oxide Synthase

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Induction of calcium-independent nitric oxide synthase activity in cultured cerebellar granule neurons

Neuroscience Letters ◽

10.1016/0304-3940(94)11191-k ◽

1995 ◽

Vol 184 (2) ◽

pp. 145-148 ◽

Cited By ~ 17

Author(s):

Ikuko Sato ◽

Yoshie Kim ◽

Toshiyuki Himi ◽

Sei-itsu Murota

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Cerebellar Granule Neurons ◽

Granule Neurons ◽

Cerebellar Granule ◽

Oxide Synthase ◽

Nitric Oxide Synthase Activity

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Regulation of functional nitric oxide synthase-1 expression in cerebellar granule neurons by heregulin is post-transcriptional, and involves mitogen-activated protein kinase

Journal of Neurochemistry ◽

10.1046/j.1471-4159.2001.00420.x ◽

2001 ◽

Vol 78 (3) ◽

pp. 552-559 ◽

Cited By ~ 8

Author(s):

Randy Krainock ◽

Sean Murphy

Keyword(s):

Nitric Oxide ◽

Protein Kinase ◽

Nitric Oxide Synthase ◽

Mitogen Activated Protein Kinase ◽

Cerebellar Granule Neurons ◽

Granule Neurons ◽

Cerebellar Granule ◽

Mitogen Activated Protein ◽

Nitric Oxide Synthase 1 ◽

Oxide Synthase

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