scholarly journals Knockdown of the neuronal nitric oxide synthase gene retard the development of the cerebellar granule neurons in vitro

2009 ◽  
Vol 239 (2) ◽  
pp. 474-481 ◽  
Author(s):  
Mei Li ◽  
Lin Wang ◽  
Ying Peng ◽  
Jia-Chuan Wang ◽  
Li-Hua Zhou
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Cerebellar Granule Neurons ◽  
Granule Neurons ◽  
Cerebellar Granule ◽  
Oxide Synthase

Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons

2014 ◽  
Vol 459 (2) ◽  
pp. 251-263 ◽  
Author(s):  
Shingo Kasamatsu ◽  
Yasuo Watanabe ◽  
Tomohiro Sawa ◽  
Takaaki Akaike ◽  
Hideshi Ihara
Keyword(s):  
Nitric Oxide ◽  
Neuronal Nitric Oxide Synthase ◽  
Cerebellar Granule Neurons ◽  
Ros Generation ◽  
Granule Neurons ◽  
Cerebellar Granule ◽  
Haem Oxygenase ◽  
Oxide Synthase ◽  
Signal Regulation ◽  
Generation Activity

Phosphorylation of neuronal nitric oxide synthase at Ser847 increased its ROS generation activity and changed the ratio of NO to ROS to regulate intracellular redox signalling, which is involved in neuroprotection against apoptosis via HO-1 (haem oxygenase 1) expression in cerebellar granule neurons.

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