scholarly journals Charms & Harms: Noni

2010 ◽  
Vol 2 (3) ◽  
pp. 254
Author(s):  
Felicity Goodyear-Smith
Keyword(s):  
Adverse Drug Reactions ◽  
Health Professionals ◽  
Herbal Medicines ◽  
Efficacy And Safety ◽  
Drug Reactions ◽  
Pharmaceutical Quality ◽  
Wide Range ◽  
Suspected Adverse Drug Reactions

SUMMARY MESSAGE: Evidence for the efficacy of noni for the wide range of medicinal purposes for which it may be used is not available. Health professionals should be aware of the possibility of (undisclosed) use of noni and its use should be avoided, or at least used only with caution, in patients on warfarin. Suspected adverse drug reactions should be reported to CARM. As with all herbal medicines, different noni products vary in their pharmaceutical quality, and the implications of this for efficacy and safety should be considered.

scholarly journals Charms & Harms: Ginkgo

2010 ◽  
Vol 2 (2) ◽  
pp. 161 ◽  
Author(s):  
Joanne Barnes
Keyword(s):  
Cognitive Impairment ◽  
Health Professionals ◽  
Herbal Medicines ◽  
Age Related Macular Degeneration ◽  
Bleeding Disorders ◽  
Efficacy And Safety ◽  
Drug Reactions ◽  
Professional Help ◽  
Age Related ◽  
Suspected Adverse Drug Reactions

SUMMARY MESSAGE: Evidence for the efficacy of ginkgo extracts for cognitive impairment and dementia, intermittent claudication, acute ischaemic stroke, tinnitus and age-related macular degeneration is unconvincing. Ginkgo preparations have been associated with haemorrhagic reactions. Health professionals should be aware of the possibility of (undisclosed) use of ginkgo; use of ginkgo should be avoided, or at least used only with caution, in patients with bleeding disorders and those taking conventional anti-platelet or anticoagulant agents. If using ginkgo, these patients should be advised to be vigilant for signs of bleeding and to seek professional help. Suspected adverse drug reactions should be reported to CARM. As with all herbal medicines, different ginkgo products vary in their pharmaceutical quality, and the implications of this for efficacy and safety should be considered.

scholarly journals Charms & Harms: Black cohosh

2010 ◽  
Vol 2 (1) ◽  
pp. 79 ◽  
Author(s):  
Joanne Barnes
Keyword(s):  
Liver Injury ◽  
Liver Function ◽  
Health Professionals ◽  
Herbal Medicines ◽  
Signs And Symptoms ◽  
Black Cohosh ◽  
Efficacy And Safety ◽  
Drug Reactions ◽  
Function Test ◽  
Suspected Adverse Drug Reactions

SUMMARY MESSAGE: Evidence for the efficacy of black cohosh extracts for treatment of menopausal symptoms is inconclusive. Black cohosh extracts have been associated with hepatotoxic reactions including changes in liver function test values, hepatitis, jaundice and hepatic failure. Health professionals should be aware of the possibility of (undisclosed) use of black cohosh, particularly among patients of menopausal age, be vigilant to signs of liver injury in patients using black cohosh, inform users of black cohosh about the possibility of hepatotoxic reactions and signs and symptoms of liver injury. Suspected adverse drug reactions should be reported to CARM. As with all herbal medicines, different black cohosh products vary in their pharmaceutical quality, and the implications of this for efficacy and safety should be considered.

scholarly journals Charms & Harms: Feverfew

2010 ◽  
Vol 2 (4) ◽  
pp. 337
Author(s):  
Felicity Goodyear-Smith
Keyword(s):  
Rheumatoid Arthritis ◽  
Health Professionals ◽  
Herbal Medicines ◽  
Allergic Reactions ◽  
Efficacy And Safety ◽  
Insufficient Evidence ◽  
Pharmaceutical Quality ◽  
Migraine Headaches

SUMMARY MESSAGE: There is insufficient evidence to support the use of feverfew for prevention of migraine headaches or for treatment of rheumatoid arthritis. Feverfew can cause mouth ulcers and gastrointestinal upsets and occasional allergic reactions. Health professionals should be aware of the possibility of (undisclosed) use of feverfew in patients on aspirin or warfarin. As with all herbal medicines, different feverfew products vary in their pharmaceutical quality, and the implications of this for efficacy and safety should be considered.

scholarly journals Aldosterone antagonists in cardiology practice

2019 ◽  
Vol 17 (2) ◽  
pp. 73-77
Author(s):  
Andrey I. Danilov ◽  
Sergey N. Kozlov ◽  
Andrey V. Evseev
Keyword(s):  
Clinical Pharmacology ◽  
Adverse Drug Reactions ◽  
Lower Risk ◽  
Adverse Reactions ◽  
Kidney Injury ◽  
Efficacy And Safety ◽  
Drug Reactions ◽  
Aldosterone Antagonists ◽  
Drug Of Choice ◽  
Wide Range

In review presents the patological effects of aldosterone, clinical pharmacology of aldosterone antagonists and their role in countering the development of cardiovascular diseases are highlighted. The results of clinical studies have demonstrated high clinical efficacy and safety of spironolactone and eplerenone in a wide range of cardiovascular risk. However, the potential adverse drug reactions associated with these drugs limit their use in some categories of patients. However, adequate monitoring of these reactions, including hyperkalemia and acute kidney injury, can be avoided. In situations where there are indications for the use of spironolactone or eplerenone, the latter is the drug of choice due to the lower risk of gender adverse reactions. The frequency of other adverse drug reactions, in particular hyperkalemia, spironolactone and eplerenone are comparable.

scholarly journals Efficacy and safety of selamectin of flea infestation in dags

2018 ◽  
Vol 53 (1) ◽  
pp. 78
Author(s):  
S. SOTIRAKI (Σ. ΣΩΤΗΡΑΚΗ) ◽  
C. HIMONAS (Χ. ΧΕΙΜΩΝΑΣ) ◽  
P. DEBOUCK ◽  
G. BITSAS (Γ. ΜΠΙΤΖΑΣ)
Keyword(s):  
Adverse Drug Reactions ◽  
Clinical Signs ◽  
Untreated Group ◽  
Field Conditions ◽  
Efficacy And Safety ◽  
Drug Reactions ◽  
Flea Infestation ◽  
Highly Effective ◽  
Monthly Dose ◽  
Adult Flea

The study was conducted at three dog shekers in Thessaloniki Greece, το confirm die efficacy and safety of selamectin aτ a minimum dosage of 6 mg/kg adminisτered topically as a monthly dose repeaτed three times in die treatment of natural i n f l a t i o n s of Ctenocephalides spp. Twenty (20) dogs, with confirmed naturally acquired flea inflations, were enrolled in die sttidy as primary patiems. All animals completed the study on day 90. Twenty-two in cornai dogs were also treated but not evaluated for efficacy (secondary patiems). There was no untreated group. Only one live adult flea was recovered on only one animal on study day 30, a reduction of die geomettical mean of 99.7 % (p < 0.0001) compared to the sτarτ of die study. Dead fleas were found on 3 animals aτ day 30 (1 or 2 per animal). No live or dead fleas were found on day 60 or on day 90. Ατ sttidy beginning on Day 0, seventy percem of sttidy animals had various clinical signs of flea inflation. These signs gradually decreased and by die end of die sttidy on day 90, only one animal remained widi a score of 1, indicating a low imensity in a single area of die body. All odier animals were free of clinical signs. No abnormal clinical signs or suspend adverse drug reactions were observed after treatment of die 20 primary or die 22 secondary patiems. The daτa collected confirm that under field conditions diree consecutive mondily doses of selamectin are highly effective and safe in die treatment and comrol of fleas in dogs.

Potential for Conflict of Interest in the Evaluation of Suspected Adverse Drug Reactions

JAMA ◽  
2004 ◽  
Vol 292 (21) ◽  
pp. 2622 ◽  
Author(s):  
Bruce M. Psaty ◽  
Curt D. Furberg ◽  
Wayne A. Ray ◽  
Noel S. Weiss
Keyword(s):  
Adverse Drug Reactions ◽  
Conflict Of Interest ◽  
Drug Reactions ◽  
Suspected Adverse Drug Reactions
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