scholarly journals Charms & Harms: Black cohosh

2010 ◽  
Vol 2 (1) ◽  
pp. 79 ◽  
Author(s):  
Joanne Barnes
Keyword(s):  
Liver Injury ◽  
Liver Function ◽  
Health Professionals ◽  
Herbal Medicines ◽  
Signs And Symptoms ◽  
Black Cohosh ◽  
Efficacy And Safety ◽  
Drug Reactions ◽  
Function Test ◽  
Suspected Adverse Drug Reactions

SUMMARY MESSAGE: Evidence for the efficacy of black cohosh extracts for treatment of menopausal symptoms is inconclusive. Black cohosh extracts have been associated with hepatotoxic reactions including changes in liver function test values, hepatitis, jaundice and hepatic failure. Health professionals should be aware of the possibility of (undisclosed) use of black cohosh, particularly among patients of menopausal age, be vigilant to signs of liver injury in patients using black cohosh, inform users of black cohosh about the possibility of hepatotoxic reactions and signs and symptoms of liver injury. Suspected adverse drug reactions should be reported to CARM. As with all herbal medicines, different black cohosh products vary in their pharmaceutical quality, and the implications of this for efficacy and safety should be considered.

scholarly journals Charms & Harms: Noni

2010 ◽  
Vol 2 (3) ◽  
pp. 254
Author(s):  
Felicity Goodyear-Smith
Keyword(s):  
Adverse Drug Reactions ◽  
Health Professionals ◽  
Herbal Medicines ◽  
Efficacy And Safety ◽  
Drug Reactions ◽  
Pharmaceutical Quality ◽  
Wide Range ◽  
Suspected Adverse Drug Reactions

SUMMARY MESSAGE: Evidence for the efficacy of noni for the wide range of medicinal purposes for which it may be used is not available. Health professionals should be aware of the possibility of (undisclosed) use of noni and its use should be avoided, or at least used only with caution, in patients on warfarin. Suspected adverse drug reactions should be reported to CARM. As with all herbal medicines, different noni products vary in their pharmaceutical quality, and the implications of this for efficacy and safety should be considered.

scholarly journals Charms & Harms: Ginkgo

2010 ◽  
Vol 2 (2) ◽  
pp. 161 ◽  
Author(s):  
Joanne Barnes
Keyword(s):  
Cognitive Impairment ◽  
Health Professionals ◽  
Herbal Medicines ◽  
Age Related Macular Degeneration ◽  
Bleeding Disorders ◽  
Efficacy And Safety ◽  
Drug Reactions ◽  
Professional Help ◽  
Age Related ◽  
Suspected Adverse Drug Reactions

SUMMARY MESSAGE: Evidence for the efficacy of ginkgo extracts for cognitive impairment and dementia, intermittent claudication, acute ischaemic stroke, tinnitus and age-related macular degeneration is unconvincing. Ginkgo preparations have been associated with haemorrhagic reactions. Health professionals should be aware of the possibility of (undisclosed) use of ginkgo; use of ginkgo should be avoided, or at least used only with caution, in patients with bleeding disorders and those taking conventional anti-platelet or anticoagulant agents. If using ginkgo, these patients should be advised to be vigilant for signs of bleeding and to seek professional help. Suspected adverse drug reactions should be reported to CARM. As with all herbal medicines, different ginkgo products vary in their pharmaceutical quality, and the implications of this for efficacy and safety should be considered.

scholarly journals Charms & Harms: Feverfew

2010 ◽  
Vol 2 (4) ◽  
pp. 337
Author(s):  
Felicity Goodyear-Smith
Keyword(s):  
Rheumatoid Arthritis ◽  
Health Professionals ◽  
Herbal Medicines ◽  
Allergic Reactions ◽  
Efficacy And Safety ◽  
Insufficient Evidence ◽  
Pharmaceutical Quality ◽  
Migraine Headaches

SUMMARY MESSAGE: There is insufficient evidence to support the use of feverfew for prevention of migraine headaches or for treatment of rheumatoid arthritis. Feverfew can cause mouth ulcers and gastrointestinal upsets and occasional allergic reactions. Health professionals should be aware of the possibility of (undisclosed) use of feverfew in patients on aspirin or warfarin. As with all herbal medicines, different feverfew products vary in their pharmaceutical quality, and the implications of this for efficacy and safety should be considered.

Patients’ and rheumatologists’ perspectives on the efficacy and safety of low-dose glucocorticoids in rheumatoid arthritis—an international survey within the GLORIA study

Rheumatology ◽  
2021 ◽  
Author(s):  
T Santiago ◽  
M Voshaar ◽  
M de Wit ◽  
P D Carvalho ◽  
F Buttgereit ◽  
...  
Keyword(s):  
Adverse Events ◽  
Health Professionals ◽  
Low Dose ◽  
Unmet Need ◽  
Signs And Symptoms ◽  
Efficacy And Safety ◽  
Serious Adverse Events ◽  
The Real ◽  
Patient Organizations ◽  
Published Evidence

Abstract Objective To evaluate the current perspectives of patients and health professionals regarding the efficacy and safety of low-dose glucocorticoids (GCs) in RA. Methods Two online surveys were disseminated to patients and health professionals, in their native language, through national patient organizations and national rheumatology medical societies, respectively. SurveyMonkey®, MediGuard.org and the Glucocorticoid Low-dose Outcome in RA Study (GLORIA) website were used to offer and deliver these surveys. Results A total of 1221 RA patients with exposure to GCs, and 414 rheumatologists completed the surveys. Patients and rheumatologists reported high levels of agreement regarding the efficacy of low-dose GCs: at least 70% considered that they are very rapid and effective in the control of signs and symptoms of RA. However, half of the patients also reported having suffered serious adverse events with GCs, and 83% described concerns about safety. The majority of rheumatologists estimated that endocrine, ophthalmologic and cutaneous adverse events affect >4% of all patients treated with low-dose GCs for 2 years, based on a heat map. Conclusions RA patients with self-reported exposure to GCs express high levels of satisfaction with low-dose GCs efficacy, as do rheumatologists. However, both expressed excessive concerns regarding the safety of GCs (greatly exceeding the published evidence data), which may compromise the optimal use of this medication. This study indicates that there is an unmet need for appropriately designed prospective trials that shed light on the real risk associated with low-dose GCs, as well as a need for renovated educational programs on the real benefits and harms of low-dose GCs, for both patients and physicians.

scholarly journals A CASE REPORT ON ROLE OF N-ACETYLCYSTEINE IN NON–ACETAMINOPHEN RELATED ACUTE LIVER INJURY

2016 ◽  
Vol 9 (6) ◽  
pp. 7
Author(s):  
Anooja Thampi
Keyword(s):  
Liver Injury ◽  
Liver Function ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Acute Liver Injury ◽  
Liver Function Tests ◽  
Function Test ◽  
Cytosolic Glutathione ◽  
Antioxidant Agent

 Acute liver failure is a clinical entity associated with a high mortality rate and majority of these patients may require liver transplantation. N-Acetylcysteine (NAC), an antioxidant agent that replenishes mitochondrial and cytosolic glutathione stores, is an antidote for acetaminophen poisoning. But their role in non–acetaminophen-related acute liver failure is still not proven. Here, we discuss about a 67 year old male patient diagnosed with hepatitis with acute liver injury who was admitted in Emergency Medicine. He was treated with N- Acetylcysteine infusion for an average of 48 hours and later it was found that his liver function tests improved. In this study, we could find that N-Acetylcysteine plays a major role in improving the liver function test of patients with non–acetaminophen-related acute liver failure.

scholarly journals Qualitative Interviews on The Diagnosis Process of Hepatitis B Among 50 Patients in Chongqing, China

2021 ◽  
Author(s):  
xiangxi zhou ◽  
fan zhang ◽  
yong Ao ◽  
chun lu ◽  
ting li ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Liver Function ◽  
Liver Function Test ◽  
Healthy Lifestyle ◽  
Negative Emotion ◽  
Qualitative Interviews ◽  
Signs And Symptoms ◽  
Health Lifestyle ◽  
Function Test

Abstract Objective: To identify the obstacles preventing and controlling hepatitis B and put forward suggestions for its prevention and treatment by describing the discovery process of hepatitis B patients. Methods: We conducted face-to-face interviews with 50 hepatitis B patients in Chongqing, China from July to August 2019 by constructing a thematic analysis framework, which included interviewees’ social demographic characteristics, diagnosis approach, signs and symptoms at the time of discovery, feelings after diagnosis, and doctor’s instructions.Results: Most of the patients were firstly found hepatitis B via physical examination when patients were asymptomatic or had no obvious symptoms. The majority of them were shocked, frightened, and at a loss when they were diagnosed. The patients could remember doctor’s instructions on keeping healthy lifestyle, but they had very little impression about doctors’ reminding about regular liver function test. Failure of regular follow-up to liver function test brought irreversible loss for certain patients.Conclusions: Most of the patients were found hepatitis B passively. The patients need professional mental help after the diagnosis to overcome the negative emotion. The doctors’ instruction should emphasize more on the importance of regular follow-up to liver function test besides health lifestyle.

scholarly journals Rash and cholestatic liver injury caused by methimazole in a woman with Turner syndrome and Graves’s disease: a case report and literature review

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jinhui Zeng ◽  
Fangtao Luo ◽  
Zhihua Lin ◽  
Yinghong Chen ◽  
Xiaoyun Wang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Function ◽  
Turner Syndrome ◽  
Adverse Drug Reactions ◽  
Clinical Manifestations ◽  
Liver Function Tests ◽  
Drug Reactions ◽  
Safe Alternative ◽  
Hepatoprotective Agents ◽  
Cholestatic Liver Injury

Abstract Background Rash and cholestatic liver injury caused by methimazole (MMI) in patients with Turner syndrome (TS) and Graves’s disease (GD) are rarely reported, and there is a paucity of reports on the management of this condition. It is not clear whether propylthiouracil (PTU) can be used as a safe alternative in this case. Case presentation: A 37-year-old woman was admitted to our hospital with rash, severe pruritus and a change in urine colour after 2 months of GD treatment with MMI. Physical examination showed rash scattered over the limbs and torso, mild jaundice of the sclera and skin, short stature, facial moles, immature external genitals and diffuse thyroid gland enlargement. Liver function tests indicated an increase in total bilirubin, direct bilirubin, total bile acid, glutamic pyruvic transaminase, glutamic oxaloacetic transaminase and alkaline phosphatase. The level of sex hormones suggested female hypergonadotropic hypogonadism. The karyotype of peripheral blood was 46, X, i(X)(q10)/45, X. After excluding biliary obstruction and other common causes of liver injury, combined with rash and abnormal liver function following oral administration of MMI, the patient was diagnosed as having TS with GD and rash and cholestatic liver injury caused by MMI. MMI was immediately discontinued, and eleven days after treatment with antihistamine and hepatoprotective agents was initiated, the rash subsided, and liver function returned to nearly normal. Because the patient did not consent to administration of 131I or thyroid surgery, hyperthyroidism was successfully controlled with PTU. No adverse drug reactions were observed after switching to PTU. Conclusions While patients with TS and GD are undergoing treatment with MMI, their clinical manifestations, liver functions, and other routine blood test results should be closely monitored. When patients with TS and GD manifest adverse reactions to MMI such as rash and cholestatic liver injury, it is necessary to discontinue MMI and treat with antihistamine and hepatoprotective agents. After the rash subsides and liver function returns to nearly normal, PTU can effectively control hyperthyroidism without adverse drug reactions.

EFFECTS OF GYNURA PROCUMBENS EXTRACT ON LIVER FUNCTION TEST OF HYPERCHOLESTEROLEMIA INDUCED RABBITS

2016 ◽  
Vol 78 (6-7) ◽  
Author(s):  
Mohd Azrul Hisham Ismail ◽  
Ebby Anuar Bahari ◽  
Farrah Shafeera Ibrahim ◽  
Razif Dasiman ◽  
Zulkhairi Amom
Keyword(s):  
Liver Injury ◽  
Liver Function ◽  
Liver Function Test ◽  
Chemical Constituents ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Predisposing Factor ◽  
Nonalcoholic Fatty Liver ◽  
Function Test

Antioxidant works against oxidant and free radicals is by donating electrons it encompasses to the radical molecules and therefore neutralising the oxidation process in the biological system. Hypercholesterolemia has been identified as one the primary predisposing factor for chronic health diseases in most industrial and developed countries.Hypercholesterolemia contributes to nonalcoholic fatty liver diseases (NAFLD). Gynura procumbens is not toxic and exhibit anti-diabetic, anti-inflammatory, anti-hypertensive and wound healing properties where the extract of this plant contains active chemical constituents such as tannins, terpenoids, sterol glycoside, saponins and flavonoids. New Zealand White Rabbits were fed with high cholesterol diet for ten weeks. Liver weight and serum liver function test (LFT) including ALP, ALT, AST and GGT were determined and analyzed. Rabbits that were given high cholesterol diet show the symptom of liver injury. ALP, ALT, AST and GGT levels indicate the liver injury. Liver injury of rabbits that were supplemented with Gynura procumbens extracts were reduced compared to rabbits that were given high cholesterol diet but not given any supplement of extract.  ALP, ALT, AST and GGT level on rabbits were given the extract were improved compared to HCD.  Supplementation of the extract lowered the levels of liver enzymes compared to the HCD. 

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