Production and economic returns from Merino weaner sheep subjected to four frequencies of anthelmintic administration in East Gippsland, Victoria

1987 ◽  
Vol 27 (6) ◽  
pp. 759 ◽  
Author(s):  
NJ Barton ◽  
IP McCausland
Keyword(s):  
Cost Price ◽  
Parasite Control ◽  
Economic Returns ◽  
Economic Return ◽  
Wool Production ◽  
Treatment Groups ◽  
Wool Growth ◽  
Price Range

In East Gippsland. Victoria. 4 treatment groups, designated 'weekly' (W), 'high' (H), 'low' (L). and 'salvage' (S), each consisting of 3 subgroups of 10 Merino weaner sheep, were given different numbers of anthelmintic doses during 1978, 1979 and 1980. The doses were respectively 5 1, 5 1, 50 (W); 9,9, 12 (H); 3,4. 6 (L); and 1, 3, 2 (S). Both anthelmintics were administered according to the manufacturers' recommendations. Subgroups were grazed on separate 1 ha plots and rotated between plots within treatments at 2-week intervals in an attempt to eliminate between paddock differences. Sheep were replaced annually. These programs resulted in major differences in wool production and final liveweight between groups. Over the 3 years of the experiment, sheep dosed frequently grew heavier (P< 0.05) and produced more wool than - did sheep in the Land S groups. Mean final liveweights for the W, H, L, and S groups respectively were 53.6, 51.4.47.0, and 46.4 kg (l.s.d. [P= 0.051 = 3.5 kg). Corresponding figures for wool growth were 5.96, 5.62. 5.07, and 5.17 kg (l.s.d. [P = 0.051 = 0.60). Mortality in the W (5.6%) and H (22%) groups was also lower than in the L (18.9%) and S (27.8%) groups. The H group gave the highest economic return of $21.81 per sheep compared with $17.61 (W group), $16.3 1 (L) and $15.06 (S group). This advantage was maintained throughout a wide cost-price range. However. as both the W and H programs selected strongly for strains of nematodes resistant to anthelmintics. anthelmintic therapy alone cannot be relied upon for long-term parasite control.

Impact of Irrigation and Hail on Palmer Amaranth (Amaranthus Palmeri) in Corn

2008 ◽  
Vol 22 (3) ◽  
pp. 448-452 ◽  
Author(s):  
Randall S. Currie ◽  
Norman L. Klocke
Keyword(s):  
Linear Models ◽  
Palmer Amaranth ◽  
Economic Returns ◽  
Corn Plant ◽  
Economic Return ◽  
Area Index ◽  
Irrigation Level ◽  
Dose Response Study ◽  
The Impact

In 2005 a hailstorm struck a long-term dose–response study of irrigation requirements and corn plant populations. This misfortune occurred again in 2006 at approximately the same growth stage. Therefore, the objectives of the studies were redirected to measure the impact of actual hail events on corn leaf area index (LAI) and the competitive interaction of escaped Palmer amaranth populations induced by hail across different levels of irrigation and corn populations. In 2005, the study treatment with the lowest corn population and level of irrigation had twice the Palmer amaranth biomass (PABM) at corn harvest compared with the highest corn population and irrigation level. Corn LAI produced simple linear models that predicted both corn grain yield and PABM. In 2007, the nonhail year, PABM was depressed 4- to 15-fold compared with hail years. PABM declined linearly from 417 kg/ha at the lowest level of irrigation and corn population to 48 kg/ha at the highest level of irrigation and corn plant population. Although economic return per increment of irrigation declined in both hail years, the trends in economic returns were still positive. This suggests that a producer with similar conditions should continue to irrigate even though his or her rate of economic return is reduced.

The influence of high ambient temperatures and plane of nutrition on wool growth rates of tropical sheep

1975 ◽  
Vol 15 (77) ◽  
pp. 753 ◽  
Author(s):  
KW Entwistle
Keyword(s):  
Heat Treatment ◽  
Treatment Period ◽  
Growth Rates ◽  
Temperature Treatment ◽  
Wool Production ◽  
Ambient Temperatures ◽  
Treatment Groups ◽  
Wool Growth ◽  
Temperature Regimen ◽  
Quality Diet

The wool production of two groups of tropical Merino sheep subjected to a simulated summer circadian temperature regimen, and fed either high or low quality diets, was compared with that of two other groups under similar nutritional conditions but held at prevailing winter ambient temperatures. The nutritional treatments were imposed for the duration of the experiment; the temperature treatments consisted of a. pre-experimental period of three weeks in which all groups were held at prevailing ambient temperatures b. heat adaptation period of one week in which the heat treatment groups were subjected to gradual increases in the circadian temperature regimen c. heat treatment period of three weeks in which the heat treatment groups were exposed to a circadian temperature regimen in which air temperatures were in excess of 38�C for approximately 7 hours day-1d. post heat treatment period of three weeks in which all groups were held at prevailing ambient temperatures. Temperature treatment had no effect on feed intake or liveweight gain; however, intakes progressively decreased in groups on the low quality diet with a similar decrease in liveweight. Wool growth rates were unaffected by temperature treatment, but were significantly lower in animals on the low quality diet. The possible significance of these results to the wool production of tropical sheep is discussed.

The effect of four schemes of parasite control on production in Merino wether weaners in two environments

1979 ◽  
Vol 19 (98) ◽  
pp. 303 ◽  
Author(s):  
IL Johnstone ◽  
FM Darvill ◽  
FL Bowen ◽  
RW Butler ◽  
KE Smart ◽  
...  
Keyword(s):  
Summer Rainfall ◽  
Parasite Control ◽  
Winter Rainfall ◽  
Preventive Program ◽  
Wool Production ◽  
Treatment Groups ◽  
Control Programs ◽  
Control Scheme ◽  
Compensatory Gain ◽  
High Level

The effect on wool production and liveweight changes of four parasite control programs, differing only in the number and timing of anthelmintic treatments, was compared in two experiments. In one program (Salvage), only individual clinically affected sheep were treated, to avert death. In a summer rainfall environment, increases in wool production of 18.4, 25.0 and 34.2% above the Salvage control scheme were recorded, respectively, for Curative (4 thiabendazole, 1 rafoxanide), Preventive (5 thiabendazole, 5 rafoxanide) and Suppressive (11 thiabendazole, 5 rafoxanide) programs of control. In the area of dominantly winter rainfall, the increases in wool production over the Salvage scheme were 17.9, 26.4 and 45.9 % for the Curative, Preventive and Suppressive programs, involving 3, 3 and 11 treatments with thiabendazole, respectively. The three treatments in the Curative program were given 3, 0 and 1 month later than in the Preventive program. Liveweight gains followed a similar pattern to wool production, but with some compensatory gain in the spring at the lower levels of control in the summer rainfall environment. The final gains were 17.4, 20.7, 23.7 and 24.7 kg in the first experiment, and 12.3, 18.3, 19.5 and 22.6 in the second experiment, for the four schemes of parasite control. The high level of production resulting from the Suppressive program was attributed to the reduction of the contamination/reinfection cycle to a low level. The experimental design involved thorough replication and required that different treatment groups be grazed separately so as to facilitate the measurement of true production differences.

scholarly journals Rituximab-Containing Risk-Adapted Treatment Strategy in Nodular Lymphocyte Predominant Hodgkin Lymphoma: 7-Years Follow-Up

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1760
Author(s):  
Novella Pugliese ◽  
Marco Picardi ◽  
Roberta Della Pepa ◽  
Claudia Giordano ◽  
Francesco Muriano ◽  
...  
Keyword(s):  
Side Effects ◽  
Hodgkin Lymphoma ◽  
Prognostic Score ◽  
Single Agent ◽  
Response To Therapy ◽  
Baseline Risk ◽  
Historical Cohort ◽  
Treatment Groups

Background: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare variant of HL that accounts for 5% of all HL cases. The expression of CD20 on neoplastic lymphocytes provides a suitable target for novel treatments based on Rituximab. Due to its rarity, consolidated and widely accepted treatment guidelines are still lacking for this disease. Methods: Between 1 December 2007 and 28 February 2018, sixteen consecutive newly diagnosed adult patients with NLPHL received Rituximab (induction ± maintenance)-based therapy, according to the baseline risk of German Hodgkin Study Group prognostic score system. The treatment efficacy and safety of the Rituximab-group were compared to those of a historical cohort of 12 patients with NLPHL who received Doxorubicin, Bleomycin, Vinblastine, Dacarbazine (ABVD) chemotherapy followed by radiotherapy (RT), if needed, according to a similar baseline risk. The primary outcome was progression-free survival (PFS) and secondary outcomes were overall survival (OS) and side-effects (according to the Common Terminology Criteria for Adverse Events, v4.03). Results: After a 7-year follow-up (range, 1–11 years), PFS was 100% for patients treated with the Rituximab-containing regimen versus 66% for patients of the historical cohort (p = 0.036). Four patients in the latter group showed insufficient response to therapy. The PFS for early favorable and early unfavorable NLPHLs was similar between treatment groups, while a better PFS was recorded for advanced-stages treated with the Rituximab-containing regimen. The OS was similar for the two treatment groups. Short- and long-term side-effects were more frequently observed in the historical cohort. Grade ≥3 neutropenia was more frequent in the historical cohort compared with the Rituximab-group (58.3% vs. 18.7%, respectively; p = 0.03). Long-term non-hematological toxicities were observed more frequently in the historical cohort. Conclusion: Our results confirm the value of Rituximab in NLPHL therapy and show that Rituximab (single-agent) induction and maintenance in a limited-stage, or Rituximab with ABVD only in the presence of risk factors, give excellent results while sparing cytotoxic agent- and/or RT-related damage. Furthermore, Rituximab inclusion in advanced-stage therapeutic strategy seems to improve PFS compared to conventional chemo-radiotherapy.

scholarly journals The long-term bio-behavioural effects of juvenile sildenafil treatment in Sprague-Dawley versus Flinders Sensitive Line rats

2021 ◽  
pp. 1-20
Author(s):  
Juandré Lambertus Bernardus Saayman ◽  
Stephanus Frederik Steyn ◽  
Christiaan Beyers Brink
Keyword(s):  
Sprague Dawley ◽  
Long Term Effects ◽  
Bdnf Level ◽  
Treatment Groups ◽  
Sd Rats ◽  
Behavioural Effects ◽  
Sensitive Line ◽  
Level Analysis ◽  
Flinders Sensitive Line

Abstract Objective: To investigate the long-term effects of juvenile sub-chronic sildenafil (SIL) treatment on the depressive-like behaviour and hippocampal brain-derived neurotrophic factor (BDNF) levels of adult Sprague-Dawley (SD) versus Flinders Sensitive Line (FSL) rats. Methods: SD and FSL rats were divided into pre-pubertal and pubertal groups, whereafter 14-day saline or SIL treatment was initiated. Pre-pubertal and pubertal rats were treated from postnatal day 21 (PND21) and PND35, respectively. The open field and forced swim tests (FST) were performed on PND60, followed by hippocampal BDNF level analysis one day later. Results: FSL rats displayed greater immobility in the FST compared to SD rats (p < 0.0001), which was reduced by SIL (p < 0.0001), regardless of treatment period. Hippocampal BDNF levels were unaltered by SIL in all treatment groups (p > 0.05). Conclusion: Juvenile sub-chronic SIL treatment reduces the risk of depressive-like behaviour manifesting during young adulthood in genetically susceptible rats.

The importance of year-round flea and roundworm prevention in lockdown and beyond

2021 ◽  
Vol 12 (2) ◽  
pp. 54-57
Author(s):  
Ian Wright
Keyword(s):  
Drug Resistance ◽  
Environmental Impact ◽  
Pivotal Role ◽  
Parasite Control ◽  
Treatment Need ◽  
Zoonotic Risk ◽  
Control Protocols

Whether routine preventative deworming regimens for Toxocara spp. in cats and dogs should be used to reduce zoonotic risk, continues to be a subject of much debate. Nurses are on the frontline of giving preventative parasite control advice and it is vital that this is based on the latest evidence to minimise zoonotic risk while ensuring over treatment does not take place. The need for routine year-round flea treatment is also fundamental to parasite control protocols in cats and dogs. The benefits of routine flea treatment need to be considered against the possible environmental impact and drug resistance issues that may be associated with long-term use. Veterinary nurses play a pivotal role in giving accurate parasite control to clients and balancing these factors based on the latest evidence.

Supplementary feeding of Merino wethers grazing weed-free stubble pastures

1981 ◽  
Vol 21 (110) ◽  
pp. 272 ◽  
Author(s):  
LG Butler
Keyword(s):  
Drinking Water ◽  
Field Trial ◽  
Compensatory Growth ◽  
Supplementary Feeding ◽  
Control Group ◽  
Apparent Digestibility ◽  
Wool Production ◽  
Wool Growth ◽  
Wheat Stubble

A field trial was conducted in the Wimmera region of Victoria to investigate the effect of several supplements on 4-year-old Merino wethers grazing a weed-free wheat stubble for 3 months, The four treatments were: a control (no supplement), urea/molasses block, 100 g/head day-1 of lupin grain, and 2 g urea plus 0.5 g Na2SO4 l-1 in the drinking water. Twenty sheep per treatment were used, and liveweight change and wool growth were measured. Although all groups lost weight, the lupin group lost only 0.5 kg per head over the 3 months of the trial, and was 3.8 kg heavier (P <0.01) than the control group, while the urea/molasses group was 2.2 kg heavier (P <0.01) than the control group. There was no effect of the urea plus sulfur supplement in the drinking water on liveweight or wool production. The urea/molasses block did not affect wool production but lupin grain stimulated wool production by 0.08 kg (P <0.05). The sheep were weighed and shorn four and a half months after the trial (August), during which time all groups grazed together on green feed. The experimental liveweight differences had disappeared, apparently due to compensatory growth. In addition, a digestibility trial was conducted in an attempt to explain some of the field results. The treatments were designed to simulate those used in the field. Lupin grain stimulated intake by 129 g day-1 (P <0.05) but had no effect on apparent digestibility of straw. The treatment simulating the urea/ molasses block (urea plus sulfur plus sucrose in the drinking water) stimulated intake by 159 g day-l (P <0.05) and tended to increase digestibility (P > 0.05). It was concluded that supplementary feeding of Merino wethers grazing weed-free stubble is unlikely to be an economic farm practice.

scholarly journals Long-term safety and efficacy of extended-interval prophylaxis with recombinant factor IX Fc fusion protein (rFIXFc) in subjects with haemophilia B

2017 ◽  
Vol 117 (03) ◽  
pp. 508-518 ◽  
Author(s):  
K.John Pasi ◽  
Kathelijn Fischer ◽  
Margaret Ragni ◽  
Beatrice Nolan ◽  
David J. Perry ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Factor Ix ◽  
Safety And Efficacy ◽  
Haemophilia B ◽  
Treatment Groups ◽  
Fc Fusion Protein ◽  
Recombinant Factor Ix ◽  
Bleeding Episodes ◽  
Supplementary Material

SummaryThe safety, efficacy, and prolonged half-life of recombinant factor IX Fc fusion protein (rFIXFc) were demonstrated in the Phase 3 B-LONG (adults/adolescents ≥12 years) and Kids B-LONG (children <12 years) studies of subjects with haemophilia B (≤2 IU/dl). Here, we report interim, long-term safety and efficacy data from B-YOND, the rFIXFc extension study. Eligible subjects who completed B-LONG or Kids B-LONG could enrol in B-YOND. There were four treatment groups: weekly prophylaxis (20–100 IU/kg every 7 days), individualised prophylaxis (100 IU/kg every 8–16 days), modified prophylaxis (further dosing personalisation to optimise prophylaxis), and episodic (ondemand) treatment. Subjects could change treatment groups at any point. Primary endpoint was inhibitor development. One hundred sixteen subjects enrolled in B-YOND. From the start of the parent studies to the B-YOND interim data cut, median duration of rFIXFc treatment was 39.5 months and 21.9 months among adults/adolescents and children, respectively; 68/93 (73.1 %) adults/adolescents and 9/23 (39.1 %) children had ≥100 cumulative rFIXFc exposure days. No inhibitors were observed. Median annualised bleeding rates (ABRs) were low in all prophylaxis regimens: weekly (≥12 years: 2.3; <6 years: 0.0; 6 to <12 years: 2.7), individualised (≥12 years: 2.3; 6 to <12 years: 2.4), and modified (≥12 years: 2.4). One or two infusions were sufficient to control 97 % (adults/adolescents) and 95 % (children) of bleeding episodes. Interim data from B-YOND are consistent with data from B-LONG and Kids B-LONG, and confirm the longterm safety of rFIXFc, absence of inhibitors, and maintenance of low ABRs with prophylactic dosing every 1 to 2 weeks.Supplementary Material to this article is available online at www.thrombosis-online.com.

The performance of pregnant and lactating Merino ewes and their lambs fed survival rations of wheat grain and sawdust

1978 ◽  
Vol 18 (90) ◽  
pp. 34 ◽  
Author(s):  
RA Hunter
Keyword(s):  
Growth Rate ◽  
Birth Weight ◽  
Survival Rate ◽  
Wheat Grain ◽  
Term Survival ◽  
Feeding Level ◽  
Wool Growth ◽  
Eucalyptus Maculata ◽  
Maintenance Ration

Merino ewes were mated at pasture and then fed in pens either a maintenance or an 80 per cent maintenance ration of wheat grain three times a week. Half the animals at each feeding level were offered Spotted Gum (Eucalyptus maculata) sawdust. Addition of sawdust to the ration did not affect liveweight change and the wool growth rate of ewes or the birth weight and growth rate of lambs. It did, however, affect the long-term survival rate of ewes. Of the ewes that died after three months of survival feeding, four were in groups fed wheat alone and one in a group fed sawdust with the wheat. The survival rate and growth rate of lambs in all treatments were poor.

Open Surgical versus Minimally Invasive in Situ Femorodistal Bypass: Long-term Results

2003 ◽  
Vol 10 (1) ◽  
pp. 117-120 ◽  
Author(s):  
Nomdo S. Renken ◽  
Cees H.A. Wittens ◽  
Peter M.T. Pattynama ◽  
Nico A.J.J. Du Bois ◽  
Lukas C. van Dijk
Keyword(s):  
Minimally Invasive ◽  
Limb Salvage ◽  
Long Term Results ◽  
Open Technique ◽  
Treatment Groups ◽  
Closed Technique ◽  
Open Versus

Purpose: To compare long-term patency and limb survival rates for the classical in situ surgical bypass procedure versus a minimally invasive technique for femorodistal revascularization. Methods: From May 1992 to June 1994, a prospective multicenter study was undertaken at 4 centers to evaluate the open versus closed technique for femorodistal bypass grafting. Of 97 patients enrolled in the trial, 73 patients (49 men; mean age 71 years) were assigned to the long-term follow-up protocol and prospectively randomized to the open (n = 38) or closed (n = 35) procedure. The classical open technique is characterized by a long incision over the length of the bypass graft, while the minimally invasive procedure involves only two short incisions over each anastomosis site (the side branches are closed with a coaxial embolization catheter system). Graft patency was evaluated with duplex imaging periodically throughout the 4-year observation period. Results: There was no statistically significant difference between the treatment groups with respect to age, sex, hypertension, ischemic heart disease, or smoking. However, the open group had a significantly greater incidence of diabetes (p = 0.037). Over a median 4.7-year follow-up (range 0.3–6.4), 9 (12%) patients (3 open and 6 closed) were lost to follow-up: 2 died and 7 refused the duplex examination. No significant differences in 4-year patency, limb salvage, or survival was demonstrated between the open versus closed treatment groups; 4-year secondary patency was 62% versus 64%, respectively, and limb salvage was 72% versus 86%. Conclusions: The closed technique for femorodistal in situ bypass procedures yields favorable long-term outcomes compared to the traditional open technique.

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