scholarly journals Pancreatic Response of Anaesthetized and Conscious Rats to Bolus Injection of Cholecystokinin-Pancreozymin

1981 ◽  
Vol 34 (3) ◽  
pp. 283 ◽  
Author(s):  
PS Oates ◽  
RGH Morgan
Keyword(s):  
Pancreatic Duct ◽  
Intravenous Injection ◽  
Pancreatic Secretion ◽  
Bolus Injection ◽  
Conscious Rats ◽  
Anaesthetized Rats ◽  
Protein Output

Pancreatic secretion was studied in anaesthetized rats tested immediately after surgery or in conscious rats tested 48 h after the cannulation of the pancreatic duct. Pancreatic flow, protein output and enzyme output were measured over a 30-min period in the unstimulated state and after the intravenous injection of bolus doses of cholecystokinin-pancreozymin (CCK-PZ) ranging from 1�25 to 20 Crick-Harper-Raper units (CHRU). Each animal received three doses of CCK-PZ, as either ascending or descending doses.

scholarly journals Pancreatic Response to Bolus Injection of Cholecystokinin-pancreozymin in Anaesthetized and Conscious Rats Fed Raw Soyaflour

1982 ◽  
Vol 35 (5) ◽  
pp. 505 ◽  
Author(s):  
PS Oates ◽  
RGH Morgan
Keyword(s):  
Bolus Injection ◽  
Acinar Cells ◽  
Simple Relationship ◽  
Experimental Conditions ◽  
Conscious Rats ◽  
Anaesthetized Rats ◽  
Hypertrophied Cell ◽  
Protein Output ◽  
Conscious Animals ◽  
Basal Flow

Pancreatic secretion was studied in rats fed raw soyaflour before (basal) and after stimulation with cholecystokinin-pancreozymin (CCK) given in either ascending or descending dose orders ranging from 1� 25 to 20 or from 20 to 1� 25 Crick-Harper-Raper units (CHRU). These results were compared with those reported previously for animals fed a stock cube diet. Two experimental conditions were used: anaesthetized animals were tested immediately after cannulation of the pancreatic duct and conscious animals were tested 48 h after surgery. Basal flow was significantly increased in anaesthetized and conscious rats fed RSF compared with the respective animals fed cubes. Mean basal protein output was also increased, but this difference was not significant. The pancreatic response to the ascending and descending doses of CCK in anaesthetized rats fed RSF was linearly related to the log of the dose of CCK in both animals fed RSF and cubes, though the response to CCK was greater in the rats fed RSF. When ascending doses of CCK were given to conscious rats fed RSF, the protein output increased up to 10 CHRU of CCK but was inhibited by 20 CHRU of CCK, whereas it decreased after the first dose of CCK (1�25 CHRU) in animals fed cubes. When descending doses of CCK were given to animals fed RSF, protein output was greatest after the first dose and no simple relationship between dose and response was seen. Compared with rats fed cubes, the pancreas in rats fed RSF thus appears to respond to a given dose of CCK with increased secretion, and conscious animals fed RSF can tolerate a higher dose of CCK before protein output is inhibited. This is consistent with an increased population of acinar cells in the animals fed RSF, with each hypertrophied cell responding to CCK with increased secretion.

Regionally perfused fatty acids augment acid-induced canine pancreatic secretion

1983 ◽  
Vol 245 (1) ◽  
pp. G78-G84
Author(s):  
A. S. Fink ◽  
M. Luxenburg ◽  
J. H. Meyer
Keyword(s):  
Fatty Acids ◽  
Small Bowel ◽  
Hydrochloric Acid ◽  
Pancreatic Duct ◽  
Pancreatic Secretion ◽  
Intestinal Perfusion ◽  
Proximal Segment ◽  
Aqueous Acid ◽  
Small Intestinal ◽  
Bicarbonate Output

To study interactions between hydrochloric acid and fatty acids on pancreatic secretion, six dogs with chronic gastric, pancreatic, and small intestinal cannulas received various combinations of the following intestinal perfusates: 20, 40, and 80 mM hydrochloric acid, oleate, dodecanoate, or 0.15 M saline. Regional intestinal perfusion (a proximal segment measuring 45 cm from the pancreatic duct versus the remaining small bowel) was utilized to separate the aqueous acid and lipid solutions. Both oleate and dodecanoate augmented the bicarbonate output induced by intraluminal acidification. In other experiments, intraluminal oleate, when combined with exogeneous intravenous secretin (12.5-900 ng . kg-1 . h-1), potentiated the secretin-induced bicarbonate output at low secretin doses. Dodecanoate also increased secretin-induced bicarbonate output. In all of these studies, protein outputs were increased by intestinal fatty acids. It is concluded that intestinal fatty acids can enhanced acid-induced canine pancreatic secretion.

An evaluation of a new method for collection of exocrine pancreatic secretion in the pig

1997 ◽  
Vol 77 (2) ◽  
pp. 339-341
Author(s):  
Tadeusz Winnicki ◽  
Wojciech Brzeski
Keyword(s):  
Pancreatic Duct ◽  
Key Words ◽  
Pancreatic Juice ◽  
Animal Behavior ◽  
Pancreatic Secretion ◽  
Surgical Techniques ◽  
New Method ◽  
Exocrine Pancreatic Secretion ◽  
Duodenal Papilla ◽  
Minor Duodenal Papilla

Surgical techniques for the cannulation of the pancreatic duct via the minor duodenal papilla in the pig are described. The dynamics of pancreatic juice secretion and animal behavior for pigs operated on according to a new method are compared with conventional animals. A means of redirecting the exocrine pancreatic secretion into the duodenum was also demonstrated. Key words: Cannulation, pancreas, pig

scholarly journals Inhibitory Effect of Central Calcitonin-Gene Related Peptide (CGRP) on Pancreatic Secretion in Conscious Rats.

2000 ◽  
Vol 50 (2) ◽  
pp. 243-248 ◽  
Author(s):  
Setsuko Kanai ◽  
Masao Masuda ◽  
Shinji Suzuki ◽  
Minoru Ohta ◽  
Yuki Yoshida ◽  
...  
Keyword(s):  
Pancreatic Secretion ◽  
Inhibitory Effect ◽  
Calcitonin Gene Related Peptide ◽  
Conscious Rats ◽  
Related Peptide ◽  
Calcitonin Gene

STIMULATORY EFFECT OF N-METHYLTYRAMINE, A CONGENER OF BEER, ON PANCREATIC SECRETION IN CONSCIOUS RATS

Pancreas ◽  
2005 ◽  
Vol 31 (4) ◽  
pp. 456
Author(s):  
K Miyasaka ◽  
S Kanai ◽  
M Ohta ◽  
E Tsutumi ◽  
S Suwa
Keyword(s):  
Pancreatic Secretion ◽  
Conscious Rats
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