scholarly journals Inhibitory Effect of Central Calcitonin-Gene Related Peptide (CGRP) on Pancreatic Secretion in Conscious Rats.

2000 ◽  
Vol 50 (2) ◽  
pp. 243-248 ◽  
Author(s):  
Setsuko Kanai ◽  
Masao Masuda ◽  
Shinji Suzuki ◽  
Minoru Ohta ◽  
Yuki Yoshida ◽  
...  
Keyword(s):  
Pancreatic Secretion ◽  
Inhibitory Effect ◽  
Calcitonin Gene Related Peptide ◽  
Conscious Rats ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Synergistic internal carotid vasodilator effects of human α-calcitonin gene-related peptide and nimodipine in conscious rats

1990 ◽  
Vol 99 (4) ◽  
pp. 830-834 ◽  
Author(s):  
Sheila M. Gardiner ◽  
Alix M. Compton ◽  
Terence Bennett ◽  
Philip A. Kemp ◽  
Ursula Ney
Keyword(s):  
Internal Carotid ◽  
Calcitonin Gene Related Peptide ◽  
Conscious Rats ◽  
Related Peptide ◽  
Calcitonin Gene

Selective Release of Somatostatin by Calcitonin Gene?Related Peptide and Influence on Pancreatic Secretion

1992 ◽  
Vol 657 (1 Calcitonin Ge) ◽  
pp. 289-298 ◽  
Author(s):  
HAILE T. DEBAS ◽  
M. TIM NELSON ◽  
NIGEL W. BUNNETT ◽  
SEAN J. MULVIHILL
Keyword(s):  
Pancreatic Secretion ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Inhibitory Effect of Calcitonin Gene-Related Peptide on Myometrial Contractility Is Diminished at Parturition1

Endocrinology ◽  
1997 ◽  
Vol 138 (10) ◽  
pp. 4207-4214 ◽  
Author(s):  
M. Naghashpour ◽  
M. I. Rosenblatt ◽  
I. M. Dickerson ◽  
G. P. Dahl
Keyword(s):  
Inhibitory Effect ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Myometrial Contractility

Hemodynamic effects of calcitonin gene-related peptide in conscious rats

1987 ◽  
Vol 19 (5-6) ◽  
pp. 307-312 ◽  
Author(s):  
Rodney W. Lappe ◽  
Mark J. Slivjak ◽  
Joy A. Todt ◽  
Robert L. Wendt
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Hemodynamic Effects ◽  
Conscious Rats ◽  
Related Peptide ◽  
Calcitonin Gene

Calcitonin Gene--Related Peptide and Induction of Hyperglycemia in Conscious Rats In Vivo

Diabetes ◽  
1990 ◽  
Vol 39 (2) ◽  
pp. 168-174 ◽  
Author(s):  
A. Yamaguchi ◽  
T. Chiba ◽  
T. Morishita ◽  
A. Nakamura ◽  
T. Inui ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Conscious Rats ◽  
Related Peptide ◽  
Calcitonin Gene

A role for calcitonin gene related peptide (CGRP) in the regulation of early B lymphocyte differentiation

1995 ◽  
Vol 73 (7) ◽  
pp. 1057-1064 ◽  
Author(s):  
Joseph P. McGillis ◽  
Vidya Rangnekar ◽  
John R. Ciallella
Keyword(s):  
Cell Differentiation ◽  
B Cell ◽  
Cell Line ◽  
Inhibitory Effect ◽  
Calcitonin Gene Related Peptide ◽  
Mouse Bone Marrow ◽  
B Cell Differentiation ◽  
Mobility Shift ◽  
Related Peptide ◽  
Calcitonin Gene

In previous studies we identified high affinity adenylyl cyclase linked receptors for calcitonin gene related peptide (CGRP) on rat T and B cells, on lymphocyte cell lines including the mouse pre-B cell line 70Z/3, and on cells in mouse bone marrow. The effect of CGRP on early B cell differentiation has been examined using the 70Z/3 cell line. CGRP inhibits the lipopolysaccharide (LPS) induction of surface immunoglobulin (sIg) protein expression in 70Z/3 cells, an effect that is associated with a decrease in the steady-state levels of Ig heavy (μ) and light (κ) chain mRNA. In this report, experiments are described that provide further information on the mechanism by which CGRP inhibits sIg expression. The kinetics of CGRP inhibition of LPS-induced sIg expression was examined in 70Z/3 cells. An optimal window for the inhibitory effect of CGRP on sIg induction occurs at least 24 h after the cells are treated with LPS. To determine whether the inhibitory effects of CGRP on sIg expression are mediated by an inhibition of NFκ-B translocation to the nucleus, electrophoretic mobility shift assays were performed using nuclear proteins from 70Z/3 cells. There was no difference in NFκ-B binding activity in cells that had been treated with LPS or LPS + CGRP, suggesting that the inhibitory effect of CGRP is not mediated by an inhibition of NFκ-B activity. These studies provide further evidence that CGRP plays an inhibitory role in early B cell differentiation. Finally, a model is proposed that describes an integrated role for CGRP in the homeostatic regulation of early B cell differentiation.Key words: neuropeptides, immune, immunoglobulin, neuroimmunology, calcitonin gene related peptides.

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