scholarly journals Haemodynamic and renal tubular responses to low-dose infusion or bolus injection of the peptide ANF in anaesthetized rats.

1989 ◽  
Vol 412 (1) ◽  
pp. 309-320 ◽  
Author(s):  
P J Harris ◽  
S L Skinner ◽  
J Zhuo
Keyword(s):  
Low Dose ◽  
Bolus Injection ◽  
Dose Infusion ◽  
Anaesthetized Rats ◽  
Renal Tubular

Induction of nucleolar changes in rat luminal cells by single injection or low-dose infusion of estradiol

Steroids ◽  
1988 ◽  
Vol 51 (1-2) ◽  
pp. 123-141 ◽  
Author(s):  
D.K. Roberts ◽  
L.A. Lavia ◽  
N. Walker ◽  
K. Anderson
Keyword(s):  
Low Dose ◽  
Single Injection ◽  
Dose Infusion ◽  
Luminal Cells

Hemodynamic, renal, and endocrine actions of ANF in sheep: effect of 24-h, low-dose infusions

1990 ◽  
Vol 258 (5) ◽  
pp. R1279-R1285 ◽  
Author(s):  
C. J. Charles ◽  
E. A. Espiner ◽  
V. A. Cameron ◽  
A. M. Richards
Keyword(s):  
Plasma Volume ◽  
Low Dose ◽  
Sodium Intake ◽  
Biological Effects ◽  
Right Atrial ◽  
Sequential Effects ◽  
Hormonal Function ◽  
Sustained Effects ◽  
Dose Infusion ◽  
Small Increments

The integrative and sustained effects of small increments in atrial natriuretic factor (ANF) on hemodynamic, renal, and hormonal function are still unclear. Accordingly, we have studied the sequential effects of 24-h, low-dose infusion (2.4 pmol.kg-1.min-1) of rat Ile-ANF or vehicle alone (control) in six normal sheep receiving a constant sodium intake. Compared with control observations, ANF infusions induced a threefold rise in venous plasma ANF and a sustained twofold rise in plasma guanosine 3',5'-cyclic monophosphate. Systolic arterial and right atrial pressures fell promptly and remained significantly reduced for the duration of the ANF infusions. These changes were associated with a sustained fall in plasma volume but no activation of renin-angiotensin-aldosterone system. In contrast to the other actions, ANF-induced natriuresis, which was significant in the first 8 h of infusion, was not sustained. These studies show that significant biological effects occur in response to small ANF increments (20-25 pmol/l) and indicate that hemodynamic factors, especially fall in plasma volume, are important in determining the renal response even at near-normal plasma ANF concentrations.

scholarly journals 931-112 A Low-dose Intravenous Aspirin, Bolus Injection, Effectively Inhibits Platelet Aggregation

1995 ◽  
Vol 25 (2) ◽  
pp. 117A ◽  
Author(s):  
Rosa-Maria Lidòn ◽  
David Garcia-Dorado ◽  
Jaume Figueras ◽  
Juan Oliveras ◽  
Anna Anglès ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Low Dose ◽  
Bolus Injection

scholarly journals Intravenous Sedation with Low-Dose Dexmedetomidine: Its Potential for Use in Dentistry

2008 ◽  
Vol 55 (3) ◽  
pp. 82-88 ◽  
Author(s):  
Sachie Ogawa ◽  
Hiroaki Seino ◽  
Hiroshi Ito ◽  
Shinya Yamazaki ◽  
Steven Ganzberg ◽  
...  
Keyword(s):  
Low Dose ◽  
Minute Ventilation ◽  
Recovery Process ◽  
Intravenous Sedation ◽  
Test Plot ◽  
Dental Procedures ◽  
Error Ratio ◽  
Dose Infusion ◽  
Post Infusion ◽  
End Tidal

Abstract This study investigated the physiologic and sedative parameters associated with a low-dose infusion of dexmedetomidine (Dex). Thirteen healthy volunteers were sedated with Dex at a loading dose of 6 mcg/kg/h for 5 minutes and a continuous infusion dose of 0.2 mcg/kg/h for 25 minutes. The recovery process was observed for 60 minutes post infusion. The tidal volume decreased significantly despite nonsignificant changes in respiratory rate, minute ventilation, oxygen saturation, and end-tidal carbon dioxide. The mean arterial pressure and heart rate also decreased significantly but within clinically acceptable levels. Amnesia to pin prick was present in 69% of subjects. A Trieger dot test plot error ratio did not show a significant change at 30 minutes post infusion despite a continued significant decrease in bispectral index. We conclude that sedation with a low dose of Dex appears to be safe and potentially efficacious for young healthy patients undergoing dental procedures.

Atrial natriuretic hormone and aldosterone regulation in salt-depleted state

1989 ◽  
Vol 257 (4) ◽  
pp. E583-E587 ◽  
Author(s):  
Y. Shenker
Keyword(s):  
Low Dose ◽  
Renal Excretion ◽  
Plasma Aldosterone ◽  
Normal Range ◽  
Natriuretic Hormone ◽  
Normal Limits ◽  
Dose Infusion ◽  
Atrial Natriuretic Hormone ◽  
Sodium And Potassium ◽  
Atrial Natriuretic

To evaluate the effect of very low-dose infusion of atrial natriuretic hormone (ANH) on aldosterone regulation, seven normal young men were infused for 2.5 h with 0.47 pmol.kg-1.min-1 of human [Ser-Tyr28]ANH or placebo. During the last 0.5 h 4 pmol.kg-1.min-1 of angiotensin II were also infused. ANH plasma levels increased from 3.46 +/- 0.25 to a maximum of 6.80 +/- 0.88 pmol/l, which is well within normal limits. Plasma aldosterone decreased almost 40%, from 40.7 +/- 5.7 to 25.9 +/- 4.9 ng/dl after 2 h. ANH infusion caused a slight decrease in blood pressure and slight increase in renal excretion of sodium and potassium. These results suggest that even small changes in ANH levels, within the normal range, have physiological significance, particularly in aldosterone regulation.

scholarly journals Prolonged low-dose infusion for gemcitabine: a systematic review

2019 ◽  
Vol Volume 12 ◽  
pp. 4859-4868
Author(s):  
Dehua Zhao ◽  
Jing Chen ◽  
Mingming Chu ◽  
Jisheng Wang
Keyword(s):  
Systematic Review ◽  
Low Dose ◽  
Dose Infusion
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