Dietary supplementation with glucogenic precusors and fatty acids improves performance and health of periparturient dairy cows

2019 ◽  
Vol 59 (1) ◽  
pp. 109 ◽  
Author(s):  
R. Klebaniuk ◽  
G. Kochman ◽  
E. Kowalczuk-Vasilev ◽  
E. R. Grela ◽  
D. Kowalczyk-Pecka ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Dairy Cows ◽  
Transition Period ◽  
Weight Ratio ◽  
Negative Energy ◽  
Health Condition ◽  
Treatment Groups ◽  
Black And White ◽  
Study Results

This experiment aimed to make a comparison between the effect of a mix of two energy preparations (a glucogenic preparation (G) and a free fatty acid preparation (F)), administered in the diet during the transition period over different periods of time (5 or 8 weeks), on the animal condition, feed intake, yield and composition of milk, and blood and urine parameters. The experimental additive was a mixture (1:1) of two energy preparations, namely, a loose mixture of propylene glycol and sodium propionate and a free fatty acid preparation in the form of rumen-undegradable pellets. The study included 50 Polish Black-and-White Holstein–Friesian dairy cows, allocated into five treatment groups, including one control (C) and four experimental ones (G1F1, G2F2, G2F1 and G1F2). The preparations were mixed at a 1:1 weight ratio (500 g per head, comprising 250G and 250F) and they were administered to all experimental groups of cows daily as a component of the experimental concentrate for 5 weeks (from the 2nd week before the expected calving and until the 3rd week of lactation). From the 4th until the 6th week of lactation, the supplementation in the experimental groups changed and animals received either no additive (G1F1), or were continuously supplemented with the G–F mix (G2F2), or received only G (G2F1) or only F (G1F2). The preparations used in the study had a long-term influence on the increase in the milk yield of cows, on the improvement of their health condition, and on the reduction of weight loss. The study results confirmed that prolongation of the supplementation until the 6th week of lactation may cause favourable changes in animal performance and milk quality. Due to different modes of action, the simultaneous supplementation of G and F reduced the negative energy balance in the cow and improved milk production and composition. The best results were obtained after administration of the mixture (1:1) of the G and F at the dose of 500 g/cow.day over the 8-week periparturient period.

scholarly journals The Capacity of Holstein-Friesian and Simmental Cows to Correct a Negative Energy Balance in Relation to Their Performance Parameters, Course of Lactation, and Selected Milk Components

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1674
Author(s):  
Ilona Strączek ◽  
Krzysztof Młynek ◽  
Agata Danielewicz
Keyword(s):  
Fatty Acid ◽  
Energy Balance ◽  
Dairy Cows ◽  
Body Condition ◽  
Body Condition Score ◽  
Negative Energy ◽  
Negative Energy Balance ◽  
Holstein Friesian ◽  
Condition Score ◽  
Peak Lactation

A significant factor in improving the performance of dairy cows is their physiological ability to correct a negative energy balance (NEB). This study, using Simmental (SIM) and Holstein-Friesian (HF) cows, aimed to assess changes in NEB (non-esterified fatty acid; body condition score; and C16:0, C18:0, and C18:1) and its effect on the metabolic efficiency of the liver (β-hydroxybutyrate and urea). The effects of NEB on daily yield, production at peak lactation and its duration, and changes in selected milk components were assessed during complete lactation. Up to peak lactation, the loss of the body condition score was similar in both breeds. Subsequently, SIM cows more efficiently restored their BCS. HF cows reached peak lactation faster and with a higher milk yield, but they were less able to correct NEB. During lactation, their non-esterified fatty acid, β-hydroxybutyrate, C16:0, C18:0, C18:1, and urea levels were persistently higher, which may indicate less efficient liver function during NEB. The dynamics of NEB were linked to levels of leptin, which has anorectic effects. Its content was usually higher in HF cows and during intensive lactogenesis. An effective response to NEB may be exploited to improve the production and nutritional properties of milk. In the long term, it may extend dairy cows’ productive life and increase lifetime yield.

scholarly journals Fatty acid profile and composition of milk protein fraction in dairy cows fed long-chain unsaturated fatty acids during the transition period

2013 ◽  
Vol 42 (11) ◽  
pp. 813-823 ◽  
Author(s):  
Francisco Palma Rennó ◽  
José Esler de Freitas Júnior ◽  
Jefferson Rodrigues Gandra ◽  
Lenita Camargo Verdurico ◽  
Marcos Veiga dos Santos ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Dairy Cows ◽  
Fatty Acid Profile ◽  
Protein Fraction ◽  
Milk Protein ◽  
Unsaturated Fatty Acids ◽  
Transition Period ◽  
Long Chain

scholarly journals Metabolic Stress in the Transition Period of Dairy Cows: Focusing on the Prepartum Period

Animals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1419
Author(s):  
Osvaldo Bogado Pascottini ◽  
Jo L. M. R. Leroy ◽  
Geert Opsomer
Keyword(s):  
Infectious Disease ◽  
Dairy Cows ◽  
Systemic Inflammation ◽  
Postpartum Period ◽  
Transition Period ◽  
Metabolic Stress ◽  
Negative Energy ◽  
Spontaneous Reduction ◽  
Fat Mobilization ◽  
Transition Dairy Cows

All modern, high-yielding dairy cows experience a certain degree of reduced insulin sensitivity, negative energy balance, and systemic inflammation during the transition period. Maladaptation to these changes may result in excessive fat mobilization, dysregulation of inflammation, immunosuppression, and, ultimately, metabolic or infectious disease in the postpartum period. Up to half of the clinical diseases in the lifespan of high-yielding dairy cows occur within 3 weeks of calving. Thus, the vast majority of prospective studies on transition dairy cows are focused on the postpartum period. However, predisposition to clinical disease and key (patho)physiological events such as a spontaneous reduction in feed intake, insulin resistance, fat mobilization, and systemic inflammation already occur in the prepartum period. This review focuses on metabolic, adaptive events occurring from drying off until calving in high-yielding cows and discusses determinants that may trigger (mal)adaptation to these events in the late prepartum period.

Operation Everest II: plasma lipid and hormonal responses during a simulated ascent of Mt. Everest

1989 ◽  
Vol 66 (3) ◽  
pp. 1430-1435 ◽  
Author(s):  
P. M. Young ◽  
M. S. Rose ◽  
J. R. Sutton ◽  
H. J. Green ◽  
A. Cymerman ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Ambient Pressure ◽  
Plasma Lipid ◽  
Weight Ratio ◽  
Density Lipoprotein ◽  
Cholesterol Concentration ◽  
Molar Ratio ◽  
Plasma Norepinephrine ◽  
Fasting Plasma

To examine the effect of hypobaric hypoxia on plasma lipid profiles, fasting blood samples were collected from six men (21–31 yr) at 760 Torr and periodically during a 40-day exposure to decreasing barometric pressure culminating in a final ambient pressure of 282 Torr. Preascent plasma total cholesterol concentration ([TC]) was decreased by 25% after the 40-day exposure (P less than 0.01). High-density lipoprotein concentrations ([HDL-C]) decreased 32% (P less than 0.001) with no alteration in the TC-to-HDL-C weight ratio. Plasma triglyceride concentration increased twofold during this period (P less than 0.01). There were no significant differences in fasting plasma free fatty acid concentrations or free fatty acid-to-albumin molar ratio throughout the study. Fasting plasma insulin levels were increased approximately twofold with no significant changes in glucagon concentration or the insulin-to-glucagon molar ratio. Plasma norepinephrine concentrations were increased threefold on reaching 282 Torr (P less than 0.01), with no significant changes in plasma epinephrine concentrations. Mean energy intake (kcal/day) decreased 42%, whereas mean body weights decreased by 8.9 +/- 0.8% (P less than 0.01) with exposure. Increased concentrations of insulin may lead to increased hepatic production of triglyceride-rich lipoproteins, thus eliciting metabolic changes independent of weight loss and dietary intake.

scholarly journals The role of rumen-protected choline in hepatic function and performance of transition dairy cows

2016 ◽  
Vol 116 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Arash Shahsavari ◽  
Michael J. D’Occhio ◽  
Rafat Al Jassim
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Dairy Cows ◽  
Milk Production ◽  
Transition Period ◽  
Hepatic Function ◽  
Negative Energy ◽  
Liver Fat ◽  
Economic Losses ◽  
Negative Effects

AbstractHigh-producing dairy cows enter a period of negative energy balance during the first weeks of lactation. Energy intake is usually sufficient to cover the increase in energy requirements for fetal growth during the period before calving, but meeting the demand for energy is often difficult during the early stages of lactation. A catabolic state predominates during the transition period, leading to the mobilisation of energy reserves (NEFA and amino acids) that are utilised mainly by the liver and muscle. Increased uptake of mobilised NEFA by the liver, combined with the limited capacity of hepatocytes to either oxidise fatty acids for energy or to incorporate esterified fatty acids into VLDL results in fatty liver syndrome and ketosis. This metabolic disturbance can affect the general health, and it causes economic losses. Different nutritional strategies have been used to restrict negative effects associated with the energy challenge in transition cows. The provision of choline in the form of rumen-protected choline (RPC) can potentially improve liver function by increasing VLDL exportation from the liver. RPC increases gene expression of microsomal TAG transfer protein and APOB100 that are required for VLDL synthesis and secretion. Studies with RPC have looked at gene expression, metabolic hormones, metabolite profiles, milk production and postpartum reproduction. A reduction in liver fat and enhanced milk production has been observed with RPC supplementation. However, the effects of RPC on health and reproduction are equivocal, which could reflect the lack of sufficient dose–response studies.

1154 Feed restriction-induced negative energy balance alters the fatty acid profiles of adipose tissue and milk fat of dairy cows

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 553-554
Author(s):  
S. E. Schmidt ◽  
K. M. Thelen ◽  
C. L. Preseault ◽  
G. A. Contreras ◽  
A. L. Lock
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Energy Balance ◽  
Dairy Cows ◽  
Milk Fat ◽  
Negative Energy ◽  
Negative Energy Balance ◽  
Feed Restriction ◽  
Fatty Acid Profiles

scholarly journals Desafíos para la salud de las vacas durante el periodo de transición. Uso de monensina

2020 ◽  
Vol 34 ◽  
pp. 7-16
Author(s):  
Estefanía Alcázar ◽  
Silvia Martínez ◽  
Josefa Madrid ◽  
Pablo Larrosa ◽  
Fuensanta Hernández
Keyword(s):  
Energy Balance ◽  
Dairy Cows ◽  
Metabolic Disorders ◽  
Transition Period ◽  
Nutrient Balance ◽  
Negative Energy ◽  
Beneficial Effects ◽  
Esterified Fatty Acids ◽  
Consequent Improvement ◽  
Positive Effect

El objetivo de este trabajo fue realizar una revisión de los efectos derivados del uso de monensina como alternativa para afrontar con mayor éxito el periodo de transición en vacas lecheras. En las vacas de leche, la transición de la preñez al inicio de la lactación es un periodo crítico que se caracteriza por presentar una mayor incidencia de enfermedades. En este periodo, el riesgo de que se presenten trastornos metabólicos y enfermedades está relacionado con el balance energético negativo en el que se encuentra la vaca, hecho que conlleva una movilización de nutrientes desde las reservas tisulares. Una de las posibles soluciones para mejorar el balance de nutrientes durante el período de transición consiste en administrar ionóforos como la monensina que actúan modificando la población microbiana del rumen. Los efectos beneficiosos de la monensina se han asociado a la producción de precursores gluconeogénicos a nivel ruminal, lo que originaría mayor disponibilidad de glucosa y la consiguiente mejora del estatus energético. Con el uso de monensina, a nivel sanguíneo se ha observado un descenso de β-hidroxibutirato, y ácidos grasos no esterificados. También han sido atribuidos efectos beneficiosos sobre la funcionalidad hepática, la absorción de ciertos minerales, la función inmune y la excreción de metano. En definitiva, el efecto positivo de la MON sobre el balance energético y la utilización de nutrientes reduciría la movilización de reservas tisulares, minimizando el riesgo de desórdenes metabólicos, mejorando la salud y por tanto el rendimiento de la vaca lechera. The aim of this research was to carry out a review of the use of monensin in dairy cows as a choice to approach more successfully the transition period. In dairy cows, the transition for the pregnancy to the beginning of lactation is a critical period which is characterized by display a higher incidence of diseases. The risk of metabolic disorders and other diseases during this time is allied to the state of negative energy balance in which the cow is, fact that involves a mobilization of nutrients from the tissue reserves. One of the possible solutions to improve the nutrient balance during the transition period is based on dispense ionophores such as monensin who modify the microbial population of the rumen. The beneficial effects of monensin have been associated with the production of gluconeogenic precursors at the ruminal level which would lead to greater availability of glucose and the consequent improvement of the energetic status. At the blood level it has been noted a decrease of β-hydroxybutyrate and non-esterified fatty acids. Beneficial effects have also been attributed to liver function, absorption of certain minerals and immune function.In brief, the positive effect of monensin on the energy balance and the use of nutrients would reduce the mobilization of tissue reserves, playing down the risk of metabolic disorders, improving the health and therefore the performance of the dairy cow.

scholarly journals Hipocalcemia e cetose - principais doenças metabólicas da vaca leiteira durante o período de transição - uma revisão de literatura

2021 ◽  
Vol 4 (5) ◽  
pp. 130-141
Author(s):  
Mylena Garcia Proto ◽  
◽  
Milena Cristina Bernardo de Barros ◽  
Bruna Stanigher Barbosa ◽  
◽  
...  
Keyword(s):  
Energy Balance ◽  
Energy Expenditure ◽  
Dairy Cows ◽  
Dry Matter ◽  
Transition Period ◽  
Negative Energy ◽  
Dry Matter Intake ◽  
Economic Losses ◽  
Balance State ◽  
Production Demand

With the increased production demand in the dairy industry comes the need to keep animals healthier, thus avoiding large economic losses due to low productivity. During the transition period, dairy cows are susceptible to the onset of infectious diseases and metabolic imbalances due to the big change in their diet, it could be poor in needed nutrients to maintain the animal's body score, with this, the dry matter intake decreases up to 40% while energy expenditure increases due to milk and colostrum production, getting into a negative energy balance state.

scholarly journals Metabolic status of crossbreed F1 Holstein × Gyr dairy cows during the transition period in two different seasons in Brazil

2018 ◽  
Vol 39 (6) ◽  
pp. 2487
Author(s):  
Tiago Facury Moreira ◽  
Elias Jorge Facury Filho ◽  
Anna Luiza Souza Alves Costa Belli ◽  
Rodrigo Melo Meneses ◽  
Fabíola Oliveira Paes Leme ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Transition Period ◽  
Great Influence ◽  
Critical Time ◽  
Good Alternative ◽  
Negative Energy ◽  
Metabolic Status ◽  
Tropical Conditions ◽  
Almost All ◽  
Beta Hydroxybutyrate

Crossbreed F1 Holstein x Gyr cows are proving to be a good alternative for milk production under tropical conditions. In order to contribute to that affirmative, our work focused on clarifying the metabolic patter of F1 Holstein x Gyr dairy cows during the most critical time in the lactation cycle, the transition period, and to compare their performance in two seasons. Blood sampling was performed on 15 cows during summer (January to April) and on 13 cows during winter (May to August), beginning three weeks before the estimated calving date, until 30 days relative to calving. The season had a great influence on the metabolic status. Almost all evaluated metabolites, with exception for aminotransferase (AST), non-esterified fatty acids (NEFA) and beta-hydroxybutyrate (BHBA), that have shown no variation among seasons, demonstrated a different patter between summer and winter. Liver functions were enhanced during the postpartum, with increased liver enzymes activity and increased concentration of cholesterol and BHB. Animals went through negative energy balance (NEB) and an alarming number of animals had experienced subclinical ketosis and high NEFA concentrations.

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