scholarly journals Metabolic Stress in the Transition Period of Dairy Cows: Focusing on the Prepartum Period

Animals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1419
Author(s):  
Osvaldo Bogado Pascottini ◽  
Jo L. M. R. Leroy ◽  
Geert Opsomer
Keyword(s):  
Infectious Disease ◽  
Dairy Cows ◽  
Systemic Inflammation ◽  
Postpartum Period ◽  
Transition Period ◽  
Metabolic Stress ◽  
Negative Energy ◽  
Spontaneous Reduction ◽  
Fat Mobilization ◽  
Transition Dairy Cows

All modern, high-yielding dairy cows experience a certain degree of reduced insulin sensitivity, negative energy balance, and systemic inflammation during the transition period. Maladaptation to these changes may result in excessive fat mobilization, dysregulation of inflammation, immunosuppression, and, ultimately, metabolic or infectious disease in the postpartum period. Up to half of the clinical diseases in the lifespan of high-yielding dairy cows occur within 3 weeks of calving. Thus, the vast majority of prospective studies on transition dairy cows are focused on the postpartum period. However, predisposition to clinical disease and key (patho)physiological events such as a spontaneous reduction in feed intake, insulin resistance, fat mobilization, and systemic inflammation already occur in the prepartum period. This review focuses on metabolic, adaptive events occurring from drying off until calving in high-yielding cows and discusses determinants that may trigger (mal)adaptation to these events in the late prepartum period.

scholarly journals Metabolic and Ruminal Fluid Markers of Dairy Cows Supplemented with a Combination of Yeast Culture and Hydrolyzed Yeast

2017 ◽  
Vol 45 (1) ◽  
pp. 8
Author(s):  
Tatiele Mumbach ◽  
Raquel Fraga e Silva Raimondo ◽  
Claudia Faccio Demarco ◽  
Vanessa Oliveira Freitas ◽  
Rodrigo Chaves Barcellos Grazziotin ◽  
...  
Keyword(s):  
Energy Balance ◽  
Dairy Cows ◽  
Postpartum Period ◽  
Transition Period ◽  
Negative Energy ◽  
Negative Energy Balance ◽  
Yeast Culture ◽  
Early Lactation ◽  
Early Postpartum Period ◽  
Early Postpartum

Background: In order to reduce the effects of a negative energy balance, some measures have been taken into account in nutritional management during the transition period. The use of yeast, has been a good alternative used to improve the rumen metabolism and helping the adjustment of the microbiotato the new diet. The aim of the study was to evaluate the effects of supplementing a combination of yeast culture and hydrolyzed yeast on the metabolism of dairy cows during the transition period.Materials, Methods & Results: The experiment was conducted in a semi-extensive system, using 20 Holstein cows, divided equally into a control group (CG) and a supplemented group (SG). The SG received 28 g/animal/day of a combination of yeast culture and hydrolyzed yeast from 20 ± 2 days pre-calving until early lactation (18 ± 3 days). Serum concentrations of non-esterified fatty acids (NEFA), albumin and urea were determined at calving, and for three time points during the early postpartum period and three time points during the early lactation period. Regarding energy metabolism, prepartum concentrations of NEFA were higher than the physiological standard in both groups. However, NEFA, albumin and urea decreased during the early postpartum period in the supplemented animals and could be attributed to the yeast in enhancing ruminal microorganisms’ cellulolytic capacity, increasing fibre digestibility and starch utilization.Discussion: The increased concentration of non-esterified fatty acids (NEFA) due to the mobilization of fat deposits that happens in the transition period, especially in the postpartum period reflects the cow’s adaptation to the negative energy balance (NEB). The lower concentrations of NEFA observed in the present study could be attributed to the effect of the yeast in enhancing the ruminal microorganisms’ cellulolytic capacity. The control cows had a BCS within the recommended range while the supplemented group had it close to the minimal limit proposed for this period. Thus, supplemented cows lost less BCS during the early postpartum period, had a lower BCS loss during the experimental period and had lower NEFA concentration that the CG. It was possible to observe a difference in serum albumin and urea between treatments only in the postpartum period. Besides showing no significant effect in BCS on prepartum period, control cows had a BCS within the recommended range while the supplemented group had it close to the minimal limit proposed for this period. Cows with high BCS prepartum had higher plasma NEFA before and after calving. It can be observed in the present study in both groups. However, a positive effect in prevent subclinical disorders might be attributed to YC, since the SG showed low NEFA plasma levels compared to the CG.  Thus, supplemented cows lost less BCS during the early postpartum period, had a lower BCS loss during the experimental period and had lower NEFA concentration that the CG. There is a negative correlation between BCS and NEFA in the early postpartum period and this information explains the results observed in the present study where BCS declines in the SG are followed by a NEFA increase. This is not so marked in the CG, indicating that SG supplementation can act by improving digestibility. Yeast supplementation promotes higher output energy, enhancing postpartum performance in dairy cows. Yeast supplementation showed benefits in early lactation compared to the prepartum and early postpartum periods, suggesting that supplementation has to have an adaptation period to be effective in protein synthesis. In conclusion, supplementation with a combination of yeast culture and hydrolyzed yeast to cows during the transition period can positively influence the energy and protein metabolism, reducing the collateral effects of negative energy balance.

scholarly journals The Physiological Roles of Vitamin E and Hypovitaminosis E in the Transition Period of High-Yielding Dairy Cows

Animals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1088
Author(s):  
Satoshi Haga ◽  
Hiroshi Ishizaki ◽  
Sanggun Roh
Keyword(s):  
Dairy Cows ◽  
High Performance ◽  
Molecular Mechanisms ◽  
Transition Period ◽  
Disease Risk ◽  
Serum Vitamin ◽  
Physiological Role ◽  
Density Lipoprotein ◽  
Alpha Tocopherol ◽  
Transition Dairy Cows

Levels of alpha-tocopherol (α-Toc) decline gradually in blood throughout prepartum, reaching lowest levels (hypovitaminosis E) around calving. Despite numerous reports about the disease risk in hypovitaminosis E and the effect of α-Toc supplementation on the health of transition dairy cows, its risk and supplemental effects are controversial. Here, we present some novel data about the disease risk of hypovitaminosis E and the effects of α-Toc supplementation in transition dairy cows. These data strongly demonstrate that hypovitaminosis E is a risk factor for the occurrence of peripartum disease. Furthermore, a study on the effectiveness of using serum vitamin levels as biomarkers to predict disease in dairy cows was reported, and a rapid field test for measuring vitamin levels was developed. By contrast, evidence for how hypovitaminosis E occurred during the transition period was scarce until the 2010s. Pioneering studies conducted with humans and rodents have identified and characterised some α-Toc-related proteins, molecular players involved in α-Toc regulation followed by a study in ruminants from the 2010s. Based on recent literature, the six physiological factors: (1) the decline in α-Toc intake from the close-up period; (2) changes in the digestive and absorptive functions of α-Toc; (3) the decline in plasma high-density lipoprotein as an α-Toc carrier; (4) increasing oxidative stress and consumption of α-Toc; (5) decreasing hepatic α-Toc transfer to circulation; and (6) increasing mammary α-Toc transfer from blood to colostrum, may be involved in α-Toc deficiency during the transition period. However, the mechanisms and pathways are poorly understood, and further studies are needed to understand the physiological role of α-Toc-related molecules in cattle. Understanding the molecular mechanisms underlying hypovitaminosis E will contribute to the prevention of peripartum disease and high performance in dairy cows.

Effect of acute nutritional restriction on periovulatory oestradiol and IGF-I in beef heifers

2001 ◽  
Vol 2001 ◽  
pp. 215-215 ◽  
Author(s):  
D.R. Mackey ◽  
A.R.G. Wylie ◽  
J.F. Roche ◽  
J.M. Sreenan ◽  
M.G. Diskin
Keyword(s):  
Energy Balance ◽  
Dairy Cows ◽  
Postpartum Period ◽  
Negative Energy ◽  
Oestrous Cycle ◽  
Negative Energy Balance ◽  
Beef Heifers ◽  
Igf I ◽  
Nutritional Restriction

Severe negative energy balance (NEB) in the postpartum period of dairy cows may be associated with declining fertility but the mechanisms by which nutrition influences reproduction are complex, poorly understood and confounded by lactation. Hence, both chronic and acute nutritional restriction of beef heifers have been used as models to examine the effects of NEB on ovarian and endocrine responses in the absence of lactation. Plasma IGF-I concentrations gradually decreased until the onset of anoestrus (Stagg et al., 1999) but concentrations may be confounded with stage of the oestrous cycle, especially around ovulation (Mackey et al., 2000). Therefore, the aim of this study was to examine the effect of nutritional restriction on periovulatory oestradiol (E2) and IGF-I concentrations.

scholarly journals The role of rumen-protected choline in hepatic function and performance of transition dairy cows

2016 ◽  
Vol 116 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Arash Shahsavari ◽  
Michael J. D’Occhio ◽  
Rafat Al Jassim
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Dairy Cows ◽  
Milk Production ◽  
Transition Period ◽  
Hepatic Function ◽  
Negative Energy ◽  
Liver Fat ◽  
Economic Losses ◽  
Negative Effects

AbstractHigh-producing dairy cows enter a period of negative energy balance during the first weeks of lactation. Energy intake is usually sufficient to cover the increase in energy requirements for fetal growth during the period before calving, but meeting the demand for energy is often difficult during the early stages of lactation. A catabolic state predominates during the transition period, leading to the mobilisation of energy reserves (NEFA and amino acids) that are utilised mainly by the liver and muscle. Increased uptake of mobilised NEFA by the liver, combined with the limited capacity of hepatocytes to either oxidise fatty acids for energy or to incorporate esterified fatty acids into VLDL results in fatty liver syndrome and ketosis. This metabolic disturbance can affect the general health, and it causes economic losses. Different nutritional strategies have been used to restrict negative effects associated with the energy challenge in transition cows. The provision of choline in the form of rumen-protected choline (RPC) can potentially improve liver function by increasing VLDL exportation from the liver. RPC increases gene expression of microsomal TAG transfer protein and APOB100 that are required for VLDL synthesis and secretion. Studies with RPC have looked at gene expression, metabolic hormones, metabolite profiles, milk production and postpartum reproduction. A reduction in liver fat and enhanced milk production has been observed with RPC supplementation. However, the effects of RPC on health and reproduction are equivocal, which could reflect the lack of sufficient dose–response studies.

scholarly journals Desafíos para la salud de las vacas durante el periodo de transición. Uso de monensina

2020 ◽  
Vol 34 ◽  
pp. 7-16
Author(s):  
Estefanía Alcázar ◽  
Silvia Martínez ◽  
Josefa Madrid ◽  
Pablo Larrosa ◽  
Fuensanta Hernández
Keyword(s):  
Energy Balance ◽  
Dairy Cows ◽  
Metabolic Disorders ◽  
Transition Period ◽  
Nutrient Balance ◽  
Negative Energy ◽  
Beneficial Effects ◽  
Esterified Fatty Acids ◽  
Consequent Improvement ◽  
Positive Effect

El objetivo de este trabajo fue realizar una revisión de los efectos derivados del uso de monensina como alternativa para afrontar con mayor éxito el periodo de transición en vacas lecheras. En las vacas de leche, la transición de la preñez al inicio de la lactación es un periodo crítico que se caracteriza por presentar una mayor incidencia de enfermedades. En este periodo, el riesgo de que se presenten trastornos metabólicos y enfermedades está relacionado con el balance energético negativo en el que se encuentra la vaca, hecho que conlleva una movilización de nutrientes desde las reservas tisulares. Una de las posibles soluciones para mejorar el balance de nutrientes durante el período de transición consiste en administrar ionóforos como la monensina que actúan modificando la población microbiana del rumen. Los efectos beneficiosos de la monensina se han asociado a la producción de precursores gluconeogénicos a nivel ruminal, lo que originaría mayor disponibilidad de glucosa y la consiguiente mejora del estatus energético. Con el uso de monensina, a nivel sanguíneo se ha observado un descenso de β-hidroxibutirato, y ácidos grasos no esterificados. También han sido atribuidos efectos beneficiosos sobre la funcionalidad hepática, la absorción de ciertos minerales, la función inmune y la excreción de metano. En definitiva, el efecto positivo de la MON sobre el balance energético y la utilización de nutrientes reduciría la movilización de reservas tisulares, minimizando el riesgo de desórdenes metabólicos, mejorando la salud y por tanto el rendimiento de la vaca lechera. The aim of this research was to carry out a review of the use of monensin in dairy cows as a choice to approach more successfully the transition period. In dairy cows, the transition for the pregnancy to the beginning of lactation is a critical period which is characterized by display a higher incidence of diseases. The risk of metabolic disorders and other diseases during this time is allied to the state of negative energy balance in which the cow is, fact that involves a mobilization of nutrients from the tissue reserves. One of the possible solutions to improve the nutrient balance during the transition period is based on dispense ionophores such as monensin who modify the microbial population of the rumen. The beneficial effects of monensin have been associated with the production of gluconeogenic precursors at the ruminal level which would lead to greater availability of glucose and the consequent improvement of the energetic status. At the blood level it has been noted a decrease of β-hydroxybutyrate and non-esterified fatty acids. Beneficial effects have also been attributed to liver function, absorption of certain minerals and immune function.In brief, the positive effect of monensin on the energy balance and the use of nutrients would reduce the mobilization of tissue reserves, playing down the risk of metabolic disorders, improving the health and therefore the performance of the dairy cow.

scholarly journals Hipocalcemia e cetose - principais doenças metabólicas da vaca leiteira durante o período de transição - uma revisão de literatura

2021 ◽  
Vol 4 (5) ◽  
pp. 130-141
Author(s):  
Mylena Garcia Proto ◽  
◽  
Milena Cristina Bernardo de Barros ◽  
Bruna Stanigher Barbosa ◽  
◽  
...  
Keyword(s):  
Energy Balance ◽  
Energy Expenditure ◽  
Dairy Cows ◽  
Dry Matter ◽  
Transition Period ◽  
Negative Energy ◽  
Dry Matter Intake ◽  
Economic Losses ◽  
Balance State ◽  
Production Demand

With the increased production demand in the dairy industry comes the need to keep animals healthier, thus avoiding large economic losses due to low productivity. During the transition period, dairy cows are susceptible to the onset of infectious diseases and metabolic imbalances due to the big change in their diet, it could be poor in needed nutrients to maintain the animal's body score, with this, the dry matter intake decreases up to 40% while energy expenditure increases due to milk and colostrum production, getting into a negative energy balance state.

scholarly journals Metabolic and mineral conditions of retained placenta in highly productive dairy cows: pathogenesis, diagnostics and prevention – a review

2017 ◽  
Vol 86 (3) ◽  
pp. 239-248 ◽  
Author(s):  
Ryszard Mordak ◽  
Józef Nicpoń ◽  
Josef Illek
Keyword(s):  
Infectious Diseases ◽  
Dairy Cows ◽  
Metabolic Stress ◽  
Negative Energy ◽  
Laboratory Diagnostics ◽  
Metabolic Disturbances ◽  
Retained Placenta ◽  
Infectious Origin ◽  
Foetal Membranes ◽  
Periparturient Cows

The time around calving in highly productive dairy cows is a critical period in terms of their metabolism, which is connected with high demands of the foetus as well as with the onset of lactation. Retained placenta in cows may have multifactorial aetiology, but in herds which are free from infectious diseases, the most important reasons are; periparturient metabolic changes and disturbances to the internal balance and stress. During the periparturient period, the most important factor causing immune suppression and hypotony of uterus in cows is metabolic stress due to hormonal and nutritional factors, including metabolic fluctuations, negative energy balance, as well as shortage of proteins, minerals, vitamins and antioxidants. This metabolic stress as a result of an imbalance in the internal metabolic homeostasis activates the hypothalamic-pituitary-adrenocortical axis (HPA) and increases serum corticosterid (cortisol) concentration, especially on the day of calving. Cortisol is a powerful immune suppressive factor that causes depression of leukocyte proliferation and their functions. The periparturient metabolic stress may also stimulate the production of catecholamines, especially adrenalin. Elevated levels of adrenalin activate adrenoreceptors of the myometrium, which in turn cause hypotony or atony of the uterus at calving in cows. Elevated levels of cortisol and adrenalin may significantly inhibit the rejection and expulsion of foetal membranes in cows, resulting in an increased incidence of their retention. These important mechanisms for placental retention in highly productive dairy cows often have primary nutritional metabolic aetiology, but they also occur during secondary metabolic disturbances and metabolic stress during calving. This metabolic and immunological aetiology and pathogenesis of retained placenta usually occur in highly productive periparturient cows on dairy farms in the absence of bovine infectious diseases, which can couse placentitis, stillbirth and the infectious origin of foetal membrane retention. The paper presents the most important metabolic, mineral and immunological disturbances as conditions for retained placenta in dairy cows. It also shows different methods of herd monitoring, important examples of clinical and laboratory diagnostics, and methods of nutritional and veterinary prevention of this health problem in dairy cows.

scholarly journals Metabolic status of crossbreed F1 Holstein × Gyr dairy cows during the transition period in two different seasons in Brazil

2018 ◽  
Vol 39 (6) ◽  
pp. 2487
Author(s):  
Tiago Facury Moreira ◽  
Elias Jorge Facury Filho ◽  
Anna Luiza Souza Alves Costa Belli ◽  
Rodrigo Melo Meneses ◽  
Fabíola Oliveira Paes Leme ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Transition Period ◽  
Great Influence ◽  
Critical Time ◽  
Good Alternative ◽  
Negative Energy ◽  
Metabolic Status ◽  
Tropical Conditions ◽  
Almost All ◽  
Beta Hydroxybutyrate

Crossbreed F1 Holstein x Gyr cows are proving to be a good alternative for milk production under tropical conditions. In order to contribute to that affirmative, our work focused on clarifying the metabolic patter of F1 Holstein x Gyr dairy cows during the most critical time in the lactation cycle, the transition period, and to compare their performance in two seasons. Blood sampling was performed on 15 cows during summer (January to April) and on 13 cows during winter (May to August), beginning three weeks before the estimated calving date, until 30 days relative to calving. The season had a great influence on the metabolic status. Almost all evaluated metabolites, with exception for aminotransferase (AST), non-esterified fatty acids (NEFA) and beta-hydroxybutyrate (BHBA), that have shown no variation among seasons, demonstrated a different patter between summer and winter. Liver functions were enhanced during the postpartum, with increased liver enzymes activity and increased concentration of cholesterol and BHB. Animals went through negative energy balance (NEB) and an alarming number of animals had experienced subclinical ketosis and high NEFA concentrations.

scholarly journals Negative energy balance and hepatic gene expression patterns in high-yielding dairy cows during the early postpartum period: a global approach

2010 ◽  
Vol 42A (3) ◽  
pp. 188-199 ◽  
Author(s):  
S. D. McCarthy ◽  
S. M. Waters ◽  
D. A. Kenny ◽  
M. G. Diskin ◽  
R. Fitzpatrick ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Energy Balance ◽  
Dairy Cows ◽  
Postpartum Period ◽  
Gene Networks ◽  
Negative Energy ◽  
Hepatic Gene Expression ◽  
Early Postpartum Period ◽  
Early Postpartum

In high-yielding dairy cows the liver undergoes extensive physiological and biochemical changes during the early postpartum period in an effort to re-establish metabolic homeostasis and to counteract the adverse effects of negative energy balance (NEB). These adaptations are likely to be mediated by significant alterations in hepatic gene expression. To gain new insights into these events an energy balance model was created using differential feeding and milking regimes to produce two groups of cows with either a mild (MNEB) or severe NEB (SNEB) status. Cows were slaughtered and liver tissues collected on days 6–7 of the first follicular wave postpartum. Using an Affymetrix 23k oligonucleotide bovine array to determine global gene expression in hepatic tissue of these cows, we found a total of 416 genes (189 up- and 227 downregulated) to be altered by SNEB. Network analysis using Ingenuity Pathway Analysis revealed that SNEB was associated with widespread changes in gene expression classified into 36 gene networks including those associated with lipid metabolism, connective tissue development and function, cell signaling, cell cycle, and metabolic diseases, the three most significant of which are discussed in detail. SNEB cows displayed reduced expression of transcription activators and signal transducers that regulate the expression of genes and gene networks associated with cell signaling and tissue repair. These alterations are linked with increased expression of abnormal cell cycle and cellular proliferation associated pathways. This study provides new information and insights on the effect of SNEB on gene expression in high-yielding Holstein Friesian dairy cows in the early postpartum period.

scholarly journals Soybean oil and calcium salts of fatty acids as fat sources for Holstein dairy cows in transition period

2014 ◽  
Vol 15 (1) ◽  
pp. 83-93 ◽  
Author(s):  
Jefferson Rodrigues Gandra ◽  
Jose Esler de Freitas Junior ◽  
Milton Maturna Filho ◽  
Rafael Villela Barletta ◽  
Lenita Camargo Verdurico ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Energy Balance ◽  
Soybean Oil ◽  
Dairy Cows ◽  
Postpartum Period ◽  
Transition Period ◽  
Physiological Parameters ◽  
Productive Performance ◽  
Calcium Salts ◽  
Glutamyl Transferase

This study aimed to evaluate the effects of using different lipid sources in diets for dairy cows during the transition period and early lactation on productive performance and physiological parameters in Holstein cows. The cows were fed with the following diets: 1) control; 2) Refined soybean oil; 3) Calcium salts of unsaturated fatty acids (Megalac-E). Diets were formulated to meet the nutritional requirements of cows during the pre-partum and postpartum period. The experimental diets affected the dry matter intake, body weight, body condition score, and energy balance in the postpartum period. The experimental diets did not affect the biochemical parameters in serum: glucose, total protein, albumin, urea, serum urea nitrogen, total cholesterol, HDL-cholesterol, non-esterified fatty acids, β-hydroxybutyrate, aspartate aminotransferase, γ-glutamyl transferase, alkaline phosphatase, also not being observed differences between the contrasts analyzed. The lipid sources soybean oil and calcium salts not directly influence the plasmatic physiological parameters of dairy cows in the period transition. But, fat supplementation in the transition period resulted in a better metabolic status and productive performance, mainly improving energy balance post-partum

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