1154 Feed restriction-induced negative energy balance alters the fatty acid profiles of adipose tissue and milk fat of dairy cows

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 553-554
Author(s):  
S. E. Schmidt ◽  
K. M. Thelen ◽  
C. L. Preseault ◽  
G. A. Contreras ◽  
A. L. Lock
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Energy Balance ◽  
Dairy Cows ◽  
Milk Fat ◽  
Negative Energy ◽  
Negative Energy Balance ◽  
Feed Restriction ◽  
Fatty Acid Profiles

scholarly journals Adipose tissue remodeling in late-lactation dairy cows during feed-restriction-induced negative energy balance

2016 ◽  
Vol 99 (12) ◽  
pp. 10009-10021 ◽  
Author(s):  
G. Andres Contreras ◽  
Kyan Thelen ◽  
Sarah E. Schmidt ◽  
Clarissa Strieder-Barboza ◽  
Courtney L. Preseault ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Energy Balance ◽  
Dairy Cows ◽  
Tissue Remodeling ◽  
Negative Energy ◽  
Negative Energy Balance ◽  
Feed Restriction ◽  
Adipose Tissue Remodeling

scholarly journals The Capacity of Holstein-Friesian and Simmental Cows to Correct a Negative Energy Balance in Relation to Their Performance Parameters, Course of Lactation, and Selected Milk Components

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1674
Author(s):  
Ilona Strączek ◽  
Krzysztof Młynek ◽  
Agata Danielewicz
Keyword(s):  
Fatty Acid ◽  
Energy Balance ◽  
Dairy Cows ◽  
Body Condition ◽  
Body Condition Score ◽  
Negative Energy ◽  
Negative Energy Balance ◽  
Holstein Friesian ◽  
Condition Score ◽  
Peak Lactation

A significant factor in improving the performance of dairy cows is their physiological ability to correct a negative energy balance (NEB). This study, using Simmental (SIM) and Holstein-Friesian (HF) cows, aimed to assess changes in NEB (non-esterified fatty acid; body condition score; and C16:0, C18:0, and C18:1) and its effect on the metabolic efficiency of the liver (β-hydroxybutyrate and urea). The effects of NEB on daily yield, production at peak lactation and its duration, and changes in selected milk components were assessed during complete lactation. Up to peak lactation, the loss of the body condition score was similar in both breeds. Subsequently, SIM cows more efficiently restored their BCS. HF cows reached peak lactation faster and with a higher milk yield, but they were less able to correct NEB. During lactation, their non-esterified fatty acid, β-hydroxybutyrate, C16:0, C18:0, C18:1, and urea levels were persistently higher, which may indicate less efficient liver function during NEB. The dynamics of NEB were linked to levels of leptin, which has anorectic effects. Its content was usually higher in HF cows and during intensive lactogenesis. An effective response to NEB may be exploited to improve the production and nutritional properties of milk. In the long term, it may extend dairy cows’ productive life and increase lifetime yield.

scholarly journals Effects of Propylene Glycol on Negative Energy Balance of Postpartum Dairy Cows

Animals ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1526
Author(s):  
Fan Zhang ◽  
Xuemei Nan ◽  
Hui Wang ◽  
Yiguang Zhao ◽  
Yuming Guo ◽  
...  
Keyword(s):  
Energy Balance ◽  
Dairy Cows ◽  
Propylene Glycol ◽  
Milk Production ◽  
Milk Fat ◽  
Metabolic Diseases ◽  
Ketone Bodies ◽  
Negative Energy ◽  
Negative Energy Balance ◽  
Research Progress

With the improvement in the intense genetic selection of dairy cows, advanced management strategies, and improved feed quality and disease control, milk production level has been greatly improved. However, the negative energy balance (NEB) is increasingly serious at the postpartum stage because the intake of nutrients cannot meet the demand of quickly improved milk production. The NEB leads to a large amount of body fat mobilization and consequently the elevated production of ketones, which causes metabolic diseases such as ketosis and fatty liver. The high milk production of dairy cows in early lactation aggravates NEB. The metabolic diseases lead to metabolic disorders, a decrease in reproductive performance, and lactation performance decline, seriously affecting the health and production of cows. Propylene glycol (PG) can alleviate NEB through gluconeogenesis and inhibit the synthesis of ketone bodies. In addition, PG improves milk yield, reproduction, and immune performance by improving plasma glucose and liver function in ketosis cows, and reduces milk fat percentage. However, a large dose of PG (above 500 g/d) has toxic and side effects in cows. The feeding method used was an oral drench. The combination of PG with some other additives can improve the effects in preventing ketosis. Overall, the present review summarizes the recent research progress in the impacts of NEB in dairy cows and the properties of PG in alleviating NEB and reducing the risk of ketosis.

scholarly journals Milk fatty acid profile related to energy balance in dairy cows

2011 ◽  
Vol 78 (4) ◽  
pp. 479-488 ◽  
Author(s):  
Josef Gross ◽  
Hendrika A van Dorland ◽  
Rupert M Bruckmaier ◽  
Frieder J Schwarz
Keyword(s):  
Fatty Acid ◽  
Energy Balance ◽  
Dairy Cows ◽  
De Novo ◽  
Post Partum ◽  
Negative Energy ◽  
Feed Restriction ◽  
Milk Fatty Acid ◽  
Early Lactation ◽  
Energy Status

Milk fatty acid (FA) profile is a dynamic pattern influenced by lactational stage, energy balance and dietary composition. In the first part of this study, effects of the energy balance during the proceeding lactation [weeks 1–21 post partum (pp)] on milk FA profile of 30 dairy cows were evaluated under a constant feeding regimen. In the second part, effects of a negative energy balance (NEB) induced by feed restriction on milk FA profile were studied in 40 multiparous dairy cows (20 feed-restricted and 20 control). Feed restriction (energy balance of −63 MJ NEL/d, restriction of 49 % of energy requirements) lasted 3 weeks starting at around 100 days in milk. Milk FA profile changed markedly from week 1 pp up to week 12 pp and remained unchanged thereafter. The proportion of saturated FA (predominantly 10:0, 12:0, 14:0 and 16:0) increased from week 1 pp up to week 12 pp, whereas monounsaturated FA, predominantly the proportion of 18:1,9c decreased as NEB in early lactation became less severe. During the induced NEB, milk FA profile showed a similarly directed pattern as during the NEB in early lactation, although changes were less marked for most FA. Milk FA composition changed rapidly within one week after initiation of feed restriction and tended to adjust to the initial composition despite maintenance of a high NEB. C18:1,9c was increased significantly during the induced NEB indicating mobilization of a considerable amount of adipose tissue. Besides 18:1,9c, changes in saturated FA, monounsaturated FA, de-novo synthesized and preformed FA (sum of FA >C16) reflected energy status in dairy cows and indicated the NEB in early lactation as well as the induced NEB by feed restriction.

scholarly journals Differing adaptations of IGF-I and its IGFBPs in dairy cows during a negative energy balance in early lactation and a negative energy balance induced by feed restriction in mid-lactation

2013 ◽  
Vol 58 (No. 9) ◽  
pp. 459-467 ◽  
Author(s):  
EC Kessler ◽  
JJ Gross ◽  
RM Bruckmaier
Keyword(s):  
Energy Balance ◽  
Dairy Cows ◽  
Negative Energy ◽  
Mrna Abundance ◽  
Negative Energy Balance ◽  
Feed Restriction ◽  
Time Points ◽  
Period 2 ◽  
Igf I ◽  
Igfbp 3

: Control of metabolic pathways is a major task of the somatotropic axis and its constituents. Insulin-like growth-factor binding proteins (IGFBPs) bind IGF-I and -II and act as carriers and regulators of their activities in blood, body fluids and tissues. Over two periods of physiological adaptation, this study investigated the binding pattern of IGF-I to IGFBPs in the plasma of 50 multiparous Holstein dairy cows and identified relationships with the hepatic mRNA abundance of IGFBPs and plasma IGF-I during the lactational negative energy balance (NEB) and during a deliberately induced NEB by feed restriction. Period 1 lasted from week 3 antepartum (a.p.) to week 12 postpartum (p.p.) and period 2, the period of feed restriction, started at around 100 DIM and lasted for three weeks with a control (C) and a restricted group (R). Blood samples and liver biopsies were collected in week 3 a.p., and in weeks 1 and 4 p.p. of period 1 and in weeks 0 and 3 of period 2. For column chromatography of IGFBPs, plasma samples of all animals were pooled by group and time points of sampling. Plasma IGF-I dropped from week 3 a.p. to week 1 p.p. and thereafter increased until week 0 (period 2) and did not change up to week 3 of period 2. The binding of IGF-I to plasma IGFBP-1 and -2 increased in period 1 from week 3 a.p. to week 4 p.p., while at the same time it decreased for IGFBP-3. During period 2, the binding of IGF-I to plasma IGFBP-1 and -2 decreased for both groups, but less for R cows. In C cows, the IGF-I binding to IGFBP-3 in plasma increased from week 0 to week 3 of period 2, whereas R cows showed a slight decrease. In period 1, hepatic mRNA abundance of IGFBP-3 followed the plasma IGFBP-3 binding in contrast to the mRNA abundances of IGFBP-1 and -2. The latter increased from week 3 a.p. to week 1 p.p. and decreased afterwards whereas IGF-I binding to IGFBP-1 and -2 increased. In week 3 of period 2, the binding of IGF-I to IGFBP-1 and -2 and their hepatic mRNA abundance were higher in R cows compared to C cows. Hepatic mRNA abundance of IGF-I was consistently positively correlated with plasma IGF-I, especially pronounced during the NEBs in week 1 p.p. (period 1) and in week 3 (period 2) in R cows. While no distinct relation between mRNA abundance of IGFBP-1 and plasma IGF-I was evident, the mRNA abundance of IGFBP-2 was inversely related to plasma IGF-I over all experimental time points independent of treatment. The mRNA abundance of IGFBP-3 was particularly correlated with plasma IGF-I during the 2 experimental stages of a NEB. Obviously IGFBP-3, but not IGFBP-1 and -2, binding in plasma closely followed the respective pattern of hepatic mRNA abundance during the entire experimental period. The fact that changes in the different plasma IGFBPs during altering metabolic stages in different stages of lactation do not always strictly follow their mRNA abundance in liver suggests tissues other than the liver flexibly contributing to the IGFBP pool in plasma as well as a partially post-transcriptional regulation of IGFBP synthesis.  

Niacin feeding to fresh dairy cows: immediate effects on health and milk production

2017 ◽  
Vol 57 (6) ◽  
pp. 1069 ◽  
Author(s):  
J. M. Havlin ◽  
P. H. Robinson ◽  
J. E. Garrett
Keyword(s):  
Fatty Acids ◽  
Energy Balance ◽  
Dairy Cows ◽  
Milk Fat ◽  
Negative Energy ◽  
Negative Energy Balance ◽  
Total Mixed Ration ◽  
Esterified Fatty Acids ◽  
Milk Component ◽  
B Vitamin

Early lactation dairy cows are frequently in negative energy balance and susceptible to ketosis, fatty liver and metritis. Because of its anti-lipolytic properties, the B-vitamin niacin could reduce negative energy balance by reducing non-esterified fatty acids for ketogenesis, thereby reducing hyperketonemia. We determined effects of feeding ruminally protected niacin (RPNi) on lipolysis during the fresh period using blood non-esterified fatty acids concentrations as a ketosis indicator, blood β-hydroxybutyrate concentrations as an indicator of lipid mobilisation, as well as dry matter (DM) intake, milk and milk component yields, in 906 multi-parity Holstein cows from ~14 days before calving through the immediate fresh period. Prior to calving, cows were co-mingled in one pen and fed the same total mixed ration without RPNi. Between 24 and 36 h postpartum, cows were assigned to fresh pens and fed the same fresh cow total mixed ration, except for RPNi at 0, 3.5, 7 or 14 g niacin/cow.day. During the close-up and fresh periods, cows were sampled for tail vein blood. Milk yield and composition was measured twice at a 140-days interval in the fresh pens postpartum. The 3.5 g/day RPNi feeding tended to decrease ketosis prevalence (% of cows with β-hydroxybutyrate ≥ 1.44 mg/dL) from 36% to 20% (P = 0.06) and also tended (P = 0.07) to increase DM intake from 19.3 to 21.5 kg DM/day versus Control. The RPNi effect tended to increase with duration of RPNi feeding, with no effects at 7 ± 3.9 days in milk, but milk (P = 0.10), milk fat (P = 0.11) and milk energy (P = 0.07) yields tending to be higher at 21 ± 3.9 days in milk. Conversely, 14 g/day RPNi had no effect on ketosis prevalence or DM intake. However, milk (P = 0.10), milk fat (P = 0.11) and milk energy (P = 0.07) yields tended to decrease versus Control. Overall, low level RPNi feeding was judged to improve health and production in fresh cows, but higher feeding levels had clear negative impacts.

scholarly journals Glucose and Fatty Acid Metabolism of Dairy Cows in a Total Mixed Ration or Pasture-Based System During Lactation

2021 ◽  
Vol 2 ◽  
Author(s):  
Mercedes García-Roche ◽  
Guillermo Cañibe ◽  
Alberto Casal ◽  
Diego A. Mattiauda ◽  
Mateo Ceriani ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Energy Balance ◽  
Dairy Cows ◽  
Mrna Expression ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Negative Energy ◽  
Negative Energy Balance ◽  
Feeding Strategies ◽  
Early Lactation

In this study, we explored mechanisms related to glucose and fatty acid metabolism in Holstein–Friesian multiparous dairy cows during lactation under two feeding strategies. From 0 to 180 days postpartum, cows were fed total mixed ration (TMR) ad libitum (non-grazing group, G0) or grazed Festuca arundinacea or Medicago sativa and were supplemented with 5.4 kg DM/d of an energy-protein concentrate (grazing group, G1). From 180 to 250 days postpartum, all cows grazed F. arundinacea and were supplemented with TMR. Plasma samples and liver biopsies were collected at −14, 35, 60, 110, 180, and 250 days in milk (DIM) for metabolite, hormone, gene expression, and western blot analysis. Our results showed increased levels of negative energy balance markers: plasma non-esterified fatty acids (NEFA), liver triglyceride and plasma β-hydroxybutyrate (BHB) (P < 0.01), triglyceride and β-hydroxybutyrate concentration were especially elevated for G1 cows. Also, hepatic mRNA expression of gluconeogenic enzymes was upregulated during early lactation (P < 0.05). In particular, methymalonyl-CoA mutase expression was increased for G0 cows (P < 0.05) while pyruvate carboxylase (PC) expression was increased for G1 cows (P < 0.05), suggesting differential gluconeogenic precursors for different feeding strategies. Phosphorylation of AMP-activated protein kinase was increased in early lactation vs. late lactation (P < 0.01) and negatively correlated with PC mRNA levels. The positive association of gluconeogenic genes with proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) hepatic expression supported the importance of this transcription factor in glucose metabolism. The peroxisome proliferator-activated receptor alpha (PPARA) mRNA was increased during early lactation (P < 0.05), and was positively associated to PPARGC1A, carnitine palmitoyl-transferase 1, and hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) mRNA expression. Alongside, hepatic mRNA expression of FABP was decreased for G1 vs. G0 cows (P < 0.05), possibly linked to impaired fatty acid transport and related to accumulation of liver triglycerides, evidencing G1 cows fail to adapt to the demands of early lactation. In sum, our results showed that metabolic adaptations related to early lactation negative energy balance can be affected by feeding strategy and might be regulated by the metabolic sensors AMPK, SIRT1, and coordinated by transcription factors PPARGC1A and PPARA.

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