Molecular diffusion analysis of dynamic blood flow and plasma separation driven by self-powered microfluidic devices

2021 ◽  
Vol 15 (3) ◽  
pp. 034106
Author(s):  
Sung Oh Woo ◽  
Myungkeun Oh ◽  
Kyle Nietfeld ◽  
Bailey Boehler ◽  
Yongki Choi
Keyword(s):  
Blood Flow ◽  
Molecular Diffusion ◽  
Microfluidic Devices ◽  
Plasma Separation ◽  
Diffusion Analysis ◽  
Self Powered

Tissue oxygen extraction during hypovolemia: role of hemoglobin P50

1987 ◽  
Vol 62 (5) ◽  
pp. 1801-1807 ◽  
Author(s):  
P. T. Schumacker ◽  
G. R. Long ◽  
L. D. Wood
Keyword(s):  
Blood Flow ◽  
Molecular Diffusion ◽  
Critical Threshold ◽  
Diffusion Limitation ◽  
Minimum Level ◽  
O2 Uptake ◽  
Reduce Blood Flow ◽  
O2 Extraction ◽  
Early Fall

When the delivery of O2 to tissues (QO2 = blood flow X O2 content) falls below a critical threshold, tissue O2 uptake (VO2) becomes limited by QO2. The mechanism responsible for this extraction limitation is not understood but may involve molecular diffusion limitation as mean capillary PO2 drops below a critical minimum level in some capillaries. We tested this hypothesis by measuring the critical QO2 necessary to maintain VO2 independent of QO2 in anesthetized, paralyzed normal dogs (n = 7) and in a second group in which PO2 at 50% saturation of hemoglobin (P50) was reduced by exchange transfusion with low-P50 erythrocytes (n = 7). QO2 was reduced in stages by removing blood volume to reduce blood flow while VO2 was measured by spirometry at each step. To the extent that O2 extraction was limited by a critical capillary PO2, we reasoned that the onset of diffusion limitation should occur at a higher QO2 with low P50, since a lower end-capillary PO2 is required to achieve the same O2 extraction. The critical QO2 (7.8 +/- 1.2 ml X min-1 X kg-1) and extraction ratio (0.63 +/- 0.06) in dogs with reduced P50 were not different from controls. At the critical delivery, mixed venous PO2 was lower in low P50 (16.1 +/- 2.9 Torr) than controls (29.9 +/- 2.3 Torr). We concluded that diffusion limitation does not initiate the early fall in VO2 below the critical QO2 and offer an alternative model to explain the onset of supply dependency.(ABSTRACT TRUNCATED AT 250 WORDS)

Energy-harvesting bioreactors: toward self-powered microfluidic devices, a mini-review

2020 ◽  
Vol 24 (7) ◽  
Author(s):  
Mengren Wu ◽  
Alireza Ahmadian Yazdi ◽  
Daniel Attinger ◽  
Jie Xu
Keyword(s):  
Energy Harvesting ◽  
Microfluidic Devices ◽  
Self Powered

A simple and rapid method for blood plasma separation driven by capillary force with an application in protein detection

2020 ◽  
Vol 12 (20) ◽  
pp. 2560-2570 ◽  
Author(s):  
Qingxue Gao ◽  
Yongjia Chang ◽  
Qingmei Deng ◽  
Hui You
Keyword(s):  
Blood Plasma ◽  
Rapid Method ◽  
Capillary Force ◽  
Protein Detection ◽  
Microfluidic Devices ◽  
Treatment Procedure ◽  
Plasma Separation ◽  
Pre Treatment ◽  
Blood Plasma Separation

Blood plasma separation is a vital sample pre-treatment procedure for microfluidic devices in blood diagnostics, and it requires reliability and speediness.

scholarly journals Coaligned Dual-Channel STED Nanoscopy and Molecular Diffusion Analysis at 20 nm Resolution

2013 ◽  
Vol 105 (1) ◽  
pp. L01-L03 ◽  
Author(s):  
Fabian Göttfert ◽  
Christian A. Wurm ◽  
Veronika Mueller ◽  
Sebastian Berning ◽  
Volker C. Cordes ◽  
...  
Keyword(s):  
Molecular Diffusion ◽  
Dual Channel ◽  
Diffusion Analysis ◽  
20 Nm

Paper-based passive pumps to generate controllable whole blood flow through microfluidic devices

Lab on a Chip ◽  
2019 ◽  
Vol 19 (22) ◽  
pp. 3787-3795 ◽  
Author(s):  
Mohamad S. Sotoudegan ◽  
Omar Mohd ◽  
Frances S. Ligler ◽  
Glenn M. Walker
Keyword(s):  
Blood Flow ◽  
Whole Blood ◽  
Microfluidic Devices ◽  
Flow Through

Grooved paper pumps provide controllable flow of complex biofluids within microfluidic devices.

Simulation of Blood Flow in Microfluidic Devices for Analysing of Video from Real Experiments

2018 ◽  
pp. 279-289 ◽  
Author(s):  
Hynek Bachratý ◽  
Katarína Bachratá ◽  
Michal Chovanec ◽  
František Kajánek ◽  
Monika Smiešková ◽  
...  
Keyword(s):  
Blood Flow ◽  
Microfluidic Devices

scholarly journals Effects of channel surface finish on blood flow in microfluidic devices

2010 ◽  
Vol 16 (7) ◽  
pp. 1091-1096 ◽  
Author(s):  
S. Prentner ◽  
D. M. Allen ◽  
L. Larcombe ◽  
S. Marson ◽  
K. Jenkins ◽  
...  
Keyword(s):  
Blood Flow ◽  
Surface Finish ◽  
Microfluidic Devices ◽  
Channel Surface

Emulsion and blood flow in microchannels of differently structure

2014 ◽  
Vol 10 ◽  
pp. 19-26 ◽  
Author(s):  
A.T. Akhmetov ◽  
A.A. Rakhimov ◽  
A.A. Valiev ◽  
R.R. Nigmatzyanova
Keyword(s):  
Blood Flow ◽  
Rheological Properties ◽  
Flow Pattern ◽  
Human Blood ◽  
General Property ◽  
Soft Lithography ◽  
Microfluidic Devices ◽  
Droplet Deformation ◽  
Traditional Methods ◽  
Dynamic Blocking

Hydrodynamic studies results are presented for O/W and W/O emulsions, biological dispersion as a human blood in microchannels obtained both by traditional methods and soft lithography ones. It’s shown that a general property of dispersions flow in microchannels is the dynamic blocking phenomenon. An analysis of blood and emulsion rheological properties is provided by data got with a precision rheometer. Experiments using microfluidic devices supported to detect droplet deformation during the dynamic blocking and an asymmetry of the dispersion flow pattern ina stepped constriction.

Effects of cardiac oscillations and lung volume on acinar gas mixing during apnea

1990 ◽  
Vol 68 (5) ◽  
pp. 2013-2018 ◽  
Author(s):  
C. F. Mackenzie ◽  
M. Skacel ◽  
G. M. Barnas ◽  
W. J. Brampton ◽  
C. A. Alana
Keyword(s):  
Blood Flow ◽  
Lung Volume ◽  
Pulmonary Blood Flow ◽  
Molecular Diffusion ◽  
Lung Parenchyma ◽  
Gas Mixing ◽  
Alveolar Region ◽  
Heart Motion ◽  
Residual Capacity ◽  
Artery Branch

We evaluated the importance of cardiogenic gas mixing in the acini of 13 dogs during 2 min of apnea. 133Xe (1-2 mCi in 4 ml of saline) was injected into an alveolar region through an occluded pulmonary artery branch, and washout was measured by gamma scintillation scanning during continued occlusion or with blood flow reinstated. The monoexponential rate constant for Xe washout (XeW) was -0.4 +/- 0.08 (SE) min-1 at functional residual capacity (FRC) with no blood flow in the injected region. It decreased by more than half at lung volumes 500 ml above and 392 ml below FRC. With intact pulmonary blood flow, XeW was -1.0 +/- 0.08 (SE) min-1 at FRC, and it increased with decreasing lung volume. However, if calculated Xe uptake by the blood was subtracted from the XeW measured with blood flow intact, resulting values at FRC and at FRC + 500 ml were not different from XeW with no blood flow. Reasonable calculation of Xe blood uptake at 392 ml below FRC was not possible because airway closure, increased shunt, and other factors affect XeW. After death, no significant XeW could be measured, which suggests that XeW caused by molecular diffusion was small. We conclude that 1) the effect of heart motion on the lung parenchyma increases acinar gas mixing during apnea, 2) this effect diminishes above or below FRC, and 3) there is probably no direct effect of pulmonary vascular pulsatility on acinar gas mixing.

Performance study of microfluidic devices for blood plasma separation—a designer’s perspective

2015 ◽  
Vol 25 (8) ◽  
pp. 084004 ◽  
Author(s):  
Siddhartha Tripathi ◽  
Y V Bala Varun Kumar ◽  
Amit Prabhakar ◽  
Suhas S Joshi ◽  
Amit Agrawal
Keyword(s):  
Blood Plasma ◽  
Microfluidic Devices ◽  
Performance Study ◽  
Plasma Separation ◽  
Blood Plasma Separation
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