A numerical study of the phase behaviors of drug particle/star triblock copolymer mixtures in dilute solutions for drug carrier application

2014 ◽  
Vol 140 (14) ◽  
pp. 144907
Author(s):  
Shanhui Wang ◽  
Chaohui Tong ◽  
Yuejin Zhu
Keyword(s):  
Triblock Copolymer ◽  
Numerical Study ◽  
Drug Carrier ◽  
Dilute Solutions ◽  
Drug Particle ◽  
Star Triblock Copolymer ◽  
Phase Behaviors

Phase behaviors of bidisperse nanoparticle/block copolymer mixtures in dilute solutions

Polymer ◽  
2010 ◽  
Vol 51 (20) ◽  
pp. 4571-4579 ◽  
Author(s):  
Qiangyong Pan ◽  
Chaohui Tong ◽  
Yuejin Zhu ◽  
Qinghua Yang
Keyword(s):  
Block Copolymer ◽  
Dilute Solutions ◽  
Phase Behaviors

Preparation of thermo-responsive drug carrier consisting of biocompatible triblock copolymer and fullerene

2021 ◽  
Author(s):  
Kohei Kitano ◽  
Kazuhiko Ishihara ◽  
Shinichi Yusa
Keyword(s):  
Ethylene Glycol ◽  
Radical Polymerization ◽  
Triblock Copolymer ◽  
Drug Carrier ◽  
Controlled Radical Polymerization ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

A triblock copolymer (PEG-b-PUEM-b-PMPC; EUM) comprising poly(ethylene glycol) (PEG), thermo-responsive poly(2-ureidoethyl methacrylate) (PUEM), and poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC) blocks was synthesized via controlled radical polymerization. PEG and PMPC blocks exhibit hydrophilicity...

A pH and UCST thermo-responsive tri-block copolymer (PAA-b-PDMA-b-P(AM-co-AN)) with micellization and gelatinization in aqueous media for drug release

2020 ◽  
Vol 44 (34) ◽  
pp. 14551-14559
Author(s):  
Cheng Zhou ◽  
Yan Chen ◽  
Mingjun Huang ◽  
Yi Ling ◽  
Liming Yang ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Drug Release ◽  
Acrylic Acid ◽  
Triblock Copolymer ◽  
Drug Carrier ◽  
Aqueous Media ◽  
Abc Triblock Copolymer ◽  
Carrier Systems ◽  
Drug Carrier Systems ◽  
Poly Acrylamide

A brand new pH and thermo-responsive amphiphilic ABC triblock copolymer of poly(acrylic acid)-block-poly(N,N-dimethyl acrylamide)-block-poly(acrylamide-co-acrylonitrile) (PAA-b-PDMA-b-P(AM-co-AN)) was applied as drug carrier systems.

scholarly journals Modulated Viscosity-Dependent Parameters for MHD Blood Flow in Microvessels Containing Oxytactic Microorganisms and Nanoparticles

Symmetry ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2114
Author(s):  
M. A. Elogail ◽  
Kh. S. Mekheimer
Keyword(s):  
Blood Flow ◽  
Numerical Study ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Equation System ◽  
Flow Features ◽  
Hypoxic Tumor ◽  
Temperature Shear ◽  
The Impact ◽  
Oxytactic Microorganisms

This work’s primary purpose is to implement a numerical study that simulates blood flow through a microvessel involving oxytactic microorganisms and nanoparticles. The oxytactic microorganisms exhibit negative chemotaxis to gradients of oxygen (oxygen repellents). These microorganisms are to batter infected hypoxic tumor cells as drug-carriers. The viscosity of blood is to vary with temperature, shear-thinning, and nanoparticle concentration. We have formulated a mathematical model then simplified it under assumptions of long wavelength and low Reynold’s number. The resulting non-linear coupled differential equation system is solved numerically with the MATHEMATICA software aid using the built-in command (ParametricNDSolve). This study treated all non-dimensional parameters defined in terms of viscosity to be variables (VP-Model), unlike some previous literature attempts that have considered these parameters mentioned above as constants (CP-Model). The achieved results assured the reliability of the (VP-Model) over the (CP-Model). Our results reveal that temperature and microorganism density increase with the thermophoresis parameter. The impact of increasing the Brownian motion parameter is to increase temperature and lessen microorganism density. Outcomes also indicate an enhancement in the microorganism density towards the hypoxic tumor regions located aside the microvessel walls by boosting oxygen concentrations in the streamflow. The current study is believed to provide further opportunities to improve drug-carrier applications in hypoxic tumor regions by better recognizing the flow features, heat, and mass transfer in such zones.

Synthesis of a dual pH and temperature responsive star triblock copolymer based on β-cyclodextrins for controlled intracellular doxorubicin delivery release

2016 ◽  
Vol 40 (10) ◽  
pp. 8397-8407 ◽  
Author(s):  
Beibei Lu ◽  
Lei Li ◽  
Jianning Wu ◽  
Lulu Wei ◽  
Jun Hou ◽  
...  
Keyword(s):  
Triblock Copolymer ◽  
Amphiphilic Copolymers ◽  
Temperature Responsive ◽  
Doxorubicin Delivery ◽  
Star Triblock Copolymer

Well-defined dual pH and temperature responsive triblock star-shaped amphiphilic copolymers of β-CD-g-(PHEMA-b-PNIPAM-b-PDMAEMA)3 were synthesized by the combination of RAFT polymerizations.

scholarly journals Surface-induced morphologies of ABC star triblock copolymer in spherical cavities

2015 ◽  
Vol 33 (11) ◽  
pp. 1503-1515 ◽  
Author(s):  
Wen-bo Jiang ◽  
Yong-yun Ji ◽  
Wen-chang Lang ◽  
Shi-ben Li ◽  
Xiang-hong Wang
Keyword(s):  
Triblock Copolymer ◽  
Spherical Cavities ◽  
Star Triblock Copolymer

scholarly journals Noncytotoxic polycaprolactone-polyethyleneglycol-ε-poly(l-lysine) triblock copolymer synthesized and self-assembled as an antibacterial drug carrier

RSC Advances ◽  
2017 ◽  
Vol 7 (63) ◽  
pp. 39718-39725 ◽  
Author(s):  
Chuncai Zhou ◽  
Xinyu Zhou ◽  
Xiaokai Su
Keyword(s):  
Antibacterial Activity ◽  
Drug Release ◽  
Triblock Copolymer ◽  
Drug Carrier ◽  
Antibacterial Drug ◽  
Self Assembled ◽  
Low Cytotoxicity

The PCL35-b-PEG45-b-EPL23 vesicles perform well in vitro drug release and antibacterial activity against Gram− and Gram+ bacteria with low cytotoxicity.

Sign in / Sign up

Export Citation Format

Share Document