Multiple transition states in unimolecular reactions: A transition state switching model. Application to the C4H8 +⋅ system

1981 ◽  
Vol 74 (4) ◽  
pp. 2228-2246 ◽  
Author(s):  
Walter J. Chesnavich ◽  
Lewis Bass ◽  
Timothy Su ◽  
Michael T. Bowers
Keyword(s):  
Transition State ◽  
Transition States ◽  
Model Application ◽  
Unimolecular Reactions ◽  
Switching Model ◽  
State Switching

Ambident Heterocyclic Reactivity: Alkylation of 4-Substituted and 2,4-Disubstituted Benzimidazoles

1994 ◽  
Vol 47 (8) ◽  
pp. 1523 ◽  
Author(s):  
MR Haque ◽  
M Rasmussen
Keyword(s):  
Hydrogen Bonding ◽  
Transition State ◽  
Electrostatic Field ◽  
Transition States ◽  
Alkyl Halides ◽  
Methyl Group ◽  
Site Selectivity ◽  
Leaving Group ◽  
Standard Set ◽  
Specific Association

The N1/N3-alkylation patterns of 4-amino-, 4-methyl- and 4-nitro-benzimidazole anions, and their 2-methyl analogues, with a standard set of primary alkyl halides (in dimethylformamide, 30°) have been determined and compared. The observed regioselectivities are dominated by proximal effects-electrostatic field, non-bonded steric and in some cases specific association (hydrogen bonding)-the interplay of which is critically dependent on the (variable) geometries of the SN2 transition states involved, in particular on the N---C distance of the developing N-alkyl bonds. The presence of a symmetrically placed 2-methyl group produces an enhanced N1/N3 site selectivity, very sensitive to the loose-tight nature of the transition state. Halide leaving group effects on butylation regioselectivities of 2-unsubstituted, 2-ethoxy-, 2-methyl- and 2-chloro-4-methylbenzimidazole anions, whilst small, are consistent with a Bell-Evans-Polanyi analysis of SN2 transition state variations, with the earlier transition states of CH3(CH2)3I leading to reduced regioselectivities.

The log kexovs. log kendo correlation as a mechanistic criterion; on the mechanisms of solvolysis of norbornyl derivatives and base-catalyzed isotope exchange of norbornanones

1976 ◽  
Vol 54 (5) ◽  
pp. 678-684 ◽  
Author(s):  
Sujit Banerjee ◽  
Nick Henry Werstiuk
Keyword(s):  
Transition State ◽  
Exchange Rates ◽  
Isotope Exchange ◽  
Transition States ◽  
Substituent Effects ◽  
Proton Exchange ◽  
Hydrogen Deuterium Exchange ◽  
Rate Data ◽  
Hydrogen Deuterium ◽  
The Difference

Rate data for the acetolysis of exo-norbornyl-sulfonates have been correlated with those for the corresponding endo isomers. It is shown that the slopes of the log kexovs. log kendo plots reflect the difference in delocalization between the transition states derived from the exo and endo isomers, respectively. The log kexovs. log kendo plot, which is comprised of the parent norbornyl sufonate and its derivatives substituted at the 5, 6, and 7 positions, has a slope of 1.11 ± 0.08, which establishes that σ bridging is absent in the transition state obtained from the exo isomer. A similar analysis of base-catalyzed hydrogen–deuterium exchange rates of norbornanones reveals that exo proton exchange is more sensitive to substituent effects than the corresponding endo process.

scholarly journals Reactivity prediction in aza-Michael additions without transition state calculations: the Ames test for mutagenicity

2020 ◽  
Vol 56 (88) ◽  
pp. 13661-13664
Author(s):  
Piers A. Townsend ◽  
Matthew N. Grayson
Keyword(s):  
Transition State ◽  
Ames Test ◽  
Transition States ◽  
Michael Additions ◽  
Novel Method

This work demonstrates a novel method for aza-Michael reactivity prediction using easily calculable intermediate structures instead of time-consuming transition states.

Theoretical study of the position of the transition state for unimolecular reactions: an entropy model

2004 ◽  
Vol 383 (1-2) ◽  
pp. 40-46 ◽  
Author(s):  
Jian-Wei Zou ◽  
Wei-Chen Chen ◽  
Che-Lun Kao ◽  
Chin-Hui Yu
Keyword(s):  
Transition State ◽  
Theoretical Study ◽  
Entropy Model ◽  
Unimolecular Reactions

Catalytic routes to fuels from C1 and oxygenate molecules

2017 ◽  
Vol 197 ◽  
pp. 9-39 ◽  
Author(s):  
Shuai Wang ◽  
Iker Agirrezabal-Telleria ◽  
Aditya Bhan ◽  
Dante Simonetti ◽  
Kazuhiro Takanabe ◽  
...  
Keyword(s):  
Transition State ◽  
Active Sites ◽  
Aldol Condensation ◽  
Bond Formation ◽  
Transition States ◽  
Solid Acids ◽  
State Theory ◽  
Side Reactions ◽  
Oh Radicals ◽  
Acid Base

This account illustrates concepts in chemical kinetics underpinned by the formalism of transition state theory using catalytic processes that enable the synthesis of molecules suitable as fuels from C1 and oxygenate reactants. Such feedstocks provide an essential bridge towards a carbon-free energy future, but their volatility and low energy density require the formation of new C–C bonds and the removal of oxygen. These transformations are described here through recent advances in our understanding of the mechanisms and site requirements in catalysis by surfaces, with emphasis on enabling concepts that tackle ubiquitous reactivity and selectivity challenges. The hurdles in forming the first C–C bond from C1 molecules are illustrated by the oxidative coupling of methane, in which surface O-atoms form OH radicals from O2 and H2O molecules. These gaseous OH species act as strong H-abstractors and activate C–H bonds with earlier transition states than oxide surfaces, thus rendering activation rates less sensitive to the weaker C–H bonds in larger alkane products than in CH4 reactants. Anhydrous carbonylation of dimethyl ether forms a single C–C bond on protons residing within inorganic voids that preferentially stabilize the kinetically-relevant transition state through van der Waals interactions that compensate for the weak CO nucleophile. Similar solvation effects, but by intrapore liquids instead of inorganic hosts, also become evident as alkenes condense within MCM-41 channels containing isolated Ni2+ active sites during dimerization reactions. Intrapore liquids preferentially stabilize transition states for C–C bond formation and product desorption, leading to unprecedented reactivity and site stability at sub-ambient temperatures and to 1-alkene dimer selectivities previously achieved only on organometallic systems with co-catalysts or activators. C1 homologation selectively forms C4 and C7 chains with a specific backbone (isobutane, triptane) on solid acids, because of methylative growth and hydride transfer rates that reflect the stability of their carbenium ion transition states and are unperturbed by side reactions at low temperatures. Aldol condensation of carbonyl compounds and ketonization of carboxylic acids form new C–C bonds concurrently with O-removal. These reactions involve analogous elementary steps and occur on acid–base site pairs on TiO2 and ZrO2 catalysts. Condensations are limited by α-H abstraction to form enolates via concerted interactions with predominantly unoccupied acid–base pairs. Ketonization is mediated instead by C–C bond formation between hydroxy-enolates and monodentate carboxylates on site pairs nearly saturated by carboxylates. Both reactions are rendered practical through bifunctional strategies, in which H2 and a Cu catalyst function scavenge unreactive intermediates, prevent sequential reactions and concomitant deactivation, and remove thermodynamic bottlenecks. Alkanal–alkene Prins condensations on solid acids occur concurrently with alkene dimerization and form molecules with new C–C bonds as skeletal isomers unattainable by other routes. Their respective transition states are of similar size, leading to selectivities that cannot sense the presence of a confining host. Prins condensation reactions benefit from weaker acid sites because their transition states are less charged than those for oligomerization and consequently less sensitive to conjugate anions that become less stable as acids weaken.

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