Protein elasticity probed with two synchrotron-based techniques

2010 ◽  
Vol 132 (8) ◽  
pp. 085103 ◽  
Author(s):  
Bogdan M. Leu ◽  
Ahmet Alatas ◽  
Harald Sinn ◽  
E. Ercan Alp ◽  
Ayman H. Said ◽  
...  
Keyword(s):  
Protein Elasticity

Protein elasticity determined by pressure tuning of the tyrosine residue of ubiquitin

2007 ◽  
Vol 127 (9) ◽  
pp. 095102 ◽  
Author(s):  
Mark M. Somoza ◽  
Johannes Wiedersich ◽  
Josef Friedrich
Keyword(s):  
Tyrosine Residue ◽  
Pressure Tuning ◽  
Protein Elasticity

Wheat seed proteins exhibit a complex mechanism of protein elasticity

2001 ◽  
Vol 1548 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Arthur S. Tatham ◽  
Larry Hayes ◽  
Peter R. Shewry ◽  
Dan W. Urry
Keyword(s):  
Seed Proteins ◽  
Complex Mechanism ◽  
Wheat Seed ◽  
Protein Elasticity

scholarly journals Rational Prediction with Molecular Dynamics for Hit Identification

2013 ◽  
Vol 12 (18) ◽  
pp. 2002-2012
Author(s):  
Sara E. Nichols ◽  
Robert V. Swift ◽  
Rommie E. Amaro
Keyword(s):  
Molecular Dynamics ◽  
Molecular Docking ◽  
Statistical Analysis ◽  
Performance Analysis ◽  
Prediction Methods ◽  
Analysis Techniques ◽  
Traditional Structure ◽  
Protein Elasticity ◽  
Dynamics Simulations ◽  
Hit Identification

Although the motions of proteins are fundamental for their function, for pragmatic reasons, the consideration of protein elasticity has traditionally been neglected in drug discovery and design. This review details protein motion, its relevance to biomolecular interactions and how it can be sampled using molecular dynamics simulations. Within this context, two major areas of research in structure-based prediction that can benefit from considering protein flexibility, binding site detection and molecular docking, are discussed. Basic classification metrics and statistical analysis techniques, which can facilitate performance analysis, are also reviewed. With hardware and software advances, molecular dynamics in combination with traditional structure-based prediction methods can potentially reduce the time and costs involved in the hit identification pipeline.

Ideal Protein Elasticity: The Elastin Models

2003 ◽  
pp. 54-93 ◽  
Author(s):  
D. W. Urry ◽  
T. Hugel ◽  
M. Seitz ◽  
H. Gaub ◽  
L. Sheiba ◽  
...  
Keyword(s):  
Ideal Protein ◽  
Protein Elasticity

scholarly journals Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
David Giganti ◽  
Kevin Yan ◽  
Carmen L. Badilla ◽  
Julio M. Fernandez ◽  
Jorge Alegre-Cebollada
Keyword(s):  
Protein Elasticity ◽  
Disulfide Isomerization
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