Protein elasticity determined by pressure tuning of the tyrosine residue of ubiquitin

2007 ◽  
Vol 127 (9) ◽  
pp. 095102 ◽  
Author(s):  
Mark M. Somoza ◽  
Johannes Wiedersich ◽  
Josef Friedrich
Keyword(s):  
Tyrosine Residue ◽  
Pressure Tuning ◽  
Protein Elasticity

Anacyclamide D8P, a prenylated cyanobactin from a Sphaerospermopsis sp. cyanobacterium

2017 ◽  
Author(s):  
Joana Martins ◽  
Niina Leikoski ◽  
Matti Wahlsten ◽  
Joana Azevedo ◽  
Jorge Antunes ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Cyclic Peptides ◽  
Biosynthetic Gene Cluster ◽  
The Novel ◽  
Tyrosine Residue ◽  
Biosynthetic Gene ◽  
Post Translational Modification ◽  
Biological Assays ◽  
Mass Spectrometric Data ◽  
Spectrometric Data

Cyanobactins are a family of linear and cyclic peptides produced through the post-translational modification of short precursor peptides. Anacyclamides are macrocyclic cyanobactins with a highly diverse sequence that are common in the genus <i>Anabaena</i>. A mass spectrometry-based screening of potential cyanobactin producers led to the discovery of a new prenylated member of this family of compounds, anacyclamide D8P (<b>1</b>), from <i>Sphaerospermopsis</i> sp. LEGE 00249. The anacyclamide biosynthetic gene cluster (<i>acy</i>) encoding the novel macrocyclic prenylated cyanobactin, was sequenced. Heterologous expression of the acy gene cluster in <i>Escherichia</i> <i>coli</i> established the connection between genomic and mass spectrometric data. Unambiguous establishment of the type and site of prenylation required the full structural elucidation of <b>1</b> using Nuclear Magnetic Resonance (NMR), which demonstrated that a forward prenylation occurred on the tyrosine residue. Compound <b>1</b> was tested in pharmacologically or ecologically relevant biological assays and revealed moderate antimicrobial activity towards the fouling bacterium <i>Halomonas aquamarina</i> CECT 5000.<br>

Hepadnavirus P protein utilizes a tyrosine residue in the TP domain to prime reverse transcription.

1994 ◽  
Vol 68 (5) ◽  
pp. 2994-2999 ◽  
Author(s):  
M Weber ◽  
V Bronsema ◽  
H Bartos ◽  
A Bosserhoff ◽  
R Bartenschlager ◽  
...  
Keyword(s):  
Reverse Transcription ◽  
Tyrosine Residue ◽  
P Protein

Hydrogen Bond between a Tyrosine Residue and the C-Ring Propionate Has a Direct Influence on Conformation and Absorption of the Bilin Cofactor in Red/Green Cyanobacteriochromes

2021 ◽  
Vol 125 (5) ◽  
pp. 1331-1342
Author(s):  
Susanne Altmayer ◽  
Sascha Jähnigen ◽  
Lisa Köhler ◽  
Christian Wiebeler ◽  
Chen Song ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Tyrosine Residue ◽  
Direct Influence

scholarly journals Role of tyrosine residue 264 of RecA for the binding of cofactor and DNA.

1993 ◽  
Vol 268 (3) ◽  
pp. 1811-1816
Author(s):  
S. Eriksson ◽  
B. Nordén ◽  
K. Morimatsu ◽  
T. Horii ◽  
M. Takahashi
Keyword(s):  
Tyrosine Residue
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