Optical manipulation of paramagnetic particles with on-chip detection using spin valve sensors

2008 ◽  
Vol 92 (1) ◽  
pp. 014105
Author(s):  
L. W. Y. Lui ◽  
K. B. Li ◽  
S. J. O’Shea ◽  
C. H. Sow
Keyword(s):  
Spin Valve ◽  
Optical Manipulation ◽  
On Chip

scholarly journals 3D printed microfluidic lab-on-a-chip device for fiber-based dual beam optical manipulation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Haoran Wang ◽  
Anton Enders ◽  
John-Alexander Preuss ◽  
Janina Bahnemann ◽  
Alexander Heisterkamp ◽  
...  
Keyword(s):  
Optical Fibers ◽  
Single Cells ◽  
Lab On A Chip ◽  
Cost Effective ◽  
Optical Manipulation ◽  
Hydrodynamic Focusing ◽  
Trapping Region ◽  
Dual Beam ◽  
3D Printed ◽  
On Chip

Abstract3D printing of microfluidic lab-on-a-chip devices enables rapid prototyping of robust and complex structures. In this work, we designed and fabricated a 3D printed lab-on-a-chip device for fiber-based dual beam optical manipulation. The final 3D printed chip offers three key features, such as (1) an optimized fiber channel design for precise alignment of optical fibers, (2) an optically clear window to visualize the trapping region, and (3) a sample channel which facilitates hydrodynamic focusing of samples. A square zig–zag structure incorporated in the sample channel increases the number of particles at the trapping site and focuses the cells and particles during experiments when operating the chip at low Reynolds number. To evaluate the performance of the device for optical manipulation, we implemented on-chip, fiber-based optical trapping of different-sized microscopic particles and performed trap stiffness measurements. In addition, optical stretching of MCF-7 cells was successfully accomplished for the purpose of studying the effects of a cytochalasin metabolite, pyrichalasin H, on cell elasticity. We observed distinct changes in the deformability of single cells treated with pyrichalasin H compared to untreated cells. These results demonstrate that 3D printed microfluidic lab-on-a-chip devices offer a cost-effective and customizable platform for applications in optical manipulation.

Machined multicore optical fibres for on-chip optical manipulation

2017 ◽  
Author(s):  
Georgia Anastasiadi ◽  
William N. MacPherson ◽  
Lynn Paterson ◽  
Mark Leonard
Keyword(s):  
Optical Manipulation ◽  
Optical Fibres ◽  
On Chip

scholarly journals On-Chip Optical Manipulation of Biomolecule Arrays with Nm Resolution

2014 ◽  
Vol 106 (2) ◽  
pp. 394a
Author(s):  
Jun Lin ◽  
Mohammad Soltani ◽  
Robert A. Forties ◽  
Summer N. Saraf ◽  
James T. Inman ◽  
...  
Keyword(s):  
Optical Manipulation ◽  
On Chip ◽  
Biomolecule Arrays

scholarly journals Plastic Lab-on-Chip for the Optical Manipulation of Single Cells

2019 ◽  
pp. 339-363 ◽  
Author(s):  
Rebeca Martínez Vázquez ◽  
Gianluca Trotta ◽  
Annalisa Volpe ◽  
Melania Paturzo ◽  
Francesco Modica ◽  
...  
Keyword(s):  
Single Cells ◽  
Optical Manipulation ◽  
Lab On Chip ◽  
On Chip

On-chip manipulation and magnetization assessment of magnetic bead ensembles by integrated spin-valve sensors

2002 ◽  
Vol 91 (10) ◽  
pp. 7445 ◽  
Author(s):  
L. Lagae ◽  
R. Wirix-Speetjens ◽  
J. Das ◽  
D. Graham ◽  
H. Ferreira ◽  
...  
Keyword(s):  
Spin Valve ◽  
Magnetic Bead ◽  
On Chip

Gut microbiome a promising target for management of respiratory diseases

2020 ◽  
Vol 477 (14) ◽  
pp. 2679-2696
Author(s):  
Riddhi Trivedi ◽  
Kalyani Barve
Keyword(s):  
Respiratory Diseases ◽  
New Technology ◽  
Bacterial Flora ◽  
Systemic Circulation ◽  
The Body ◽  
Lung Pathology ◽  
Promising Target ◽  
Current Therapies ◽  
Intestinal Microbial Flora ◽  
On Chip

The intestinal microbial flora has risen to be one of the important etiological factors in the development of diseases like colorectal cancer, obesity, diabetes, inflammatory bowel disease, anxiety and Parkinson's. The emergence of the association between bacterial flora and lungs led to the discovery of the gut–lung axis. Dysbiosis of several species of colonic bacteria such as Firmicutes and Bacteroidetes and transfer of these bacteria from gut to lungs via lymphatic and systemic circulation are associated with several respiratory diseases such as lung cancer, asthma, tuberculosis, cystic fibrosis, etc. Current therapies for dysbiosis include use of probiotics, prebiotics and synbiotics to restore the balance between various species of beneficial bacteria. Various approaches like nanotechnology and microencapsulation have been explored to increase the permeability and viability of probiotics in the body. The need of the day is comprehensive study of mechanisms behind dysbiosis, translocation of microbiota from gut to lung through various channels and new technology for evaluating treatment to correct this dysbiosis which in turn can be used to manage various respiratory diseases. Microfluidics and organ on chip model are emerging technologies that can satisfy these needs. This review gives an overview of colonic commensals in lung pathology and novel systems that help in alleviating symptoms of lung diseases. We have also hypothesized new models to help in understanding bacterial pathways involved in the gut–lung axis as well as act as a futuristic approach in finding treatment of respiratory diseases caused by dysbiosis.

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