On-chip manipulation and magnetization assessment of magnetic bead ensembles by integrated spin-valve sensors

2002 ◽  
Vol 91 (10) ◽  
pp. 7445 ◽  
Author(s):  
L. Lagae ◽  
R. Wirix-Speetjens ◽  
J. Das ◽  
D. Graham ◽  
H. Ferreira ◽  
...  
Keyword(s):  
Spin Valve ◽  
Magnetic Bead ◽  
On Chip

The fabrication of high sensitive spin-valve sensor for magnetic bead detection

2004 ◽  
Vol 201 (8) ◽  
pp. 1961-1964 ◽  
Author(s):  
Hyun Jong Kim ◽  
Sung Ho Jang ◽  
Kyu Hwan Oh ◽  
Tae Song Kim ◽  
Kwang Youn Kim
Keyword(s):  
Spin Valve ◽  
Magnetic Bead

Closed loop microfluidic platform based on domain wall magnetic conduits: a novel tool for biology and medicine

2014 ◽  
Vol 1686 ◽  
Author(s):  
M. Monticelli ◽  
D. Petti ◽  
E. Albisetti ◽  
M. Cantoni ◽  
E. Guerriero ◽  
...  
Keyword(s):  
Magnetic Particle ◽  
Closed Loop ◽  
Domain Walls ◽  
Voltage Drop ◽  
Magnetic Domain ◽  
Magnetic Bead ◽  
Electrical Contacts ◽  
Stray Field ◽  
Magnetic Domain Walls ◽  
On Chip

ABSTRACTIn this paper we present an innovative on-chip platform suitable for the simultaneous manipulation and detection of the transit of a single magnetic bead. This system is based on the controlled displacement of constrained magnetic domain walls (DWs) that are used to move and sense particles in suspension over the chip. To this scope, the high stray field from the transverse DWs created at the corners of ferromagnetic zig-zag structures is used for particles manipulation, while electrical contacts flanking a single corner are employed to simultaneously monitor the DW passage through that corner, via anisotropic magneto resistance (AMR) measurements. A single DW carrying a magnetic particle is nucleated and manipulated within the zig-zag shaped magnetic conduit, trough the action of external magnetic fields. At the same time, the variation of the voltage drop across a corner flanked by a pair of electrical leads is measured, allowing to detect the transit of the DW thanks to the change of the relative orientation of current and spins at the corner related to the peculiar micromagnetic configuration of the DW (AMR). Work is in progress in order to selectively distinguish the transit of a naked DW from that of a DW bound to a magnetic particle. This work paves the way to the development of a closed-loop microlfuidic platform for on-chip bead manipulation, where single bead can be finely moved and their motion continuously checked, via AMR electrical detection and without need of optical monitoring, in a fully integrated closed-loop system.

Detection of single micron-sized magnetic bead and magnetic nanoparticles using spin valve sensors for biological applications

2003 ◽  
Vol 93 (10) ◽  
pp. 7557-7559 ◽  
Author(s):  
Guanxiong Li ◽  
Vikram Joshi ◽  
Robert L. White ◽  
Shan X. Wang ◽  
Jennifer T. Kemp ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Spin Valve ◽  
Magnetic Bead ◽  
Biological Applications

Magnetic actuator for the control and mixing of magnetic bead-based reactions on-chip

2014 ◽  
Vol 406 (26) ◽  
pp. 6607-6616 ◽  
Author(s):  
Miguel Berenguel-Alonso ◽  
Xavier Granados ◽  
Jordi Faraudo ◽  
Julián Alonso-Chamarro ◽  
Mar Puyol
Keyword(s):  
Magnetic Bead ◽  
Magnetic Actuator ◽  
On Chip

Magnetic Spin Valve Sensors with Different Geometry to Magnetic Bead Detection for Biosensor Application

2007 ◽  
Vol 1032 ◽  
Author(s):  
Jeong Dae Suh ◽  
Myung Ae Chung
Keyword(s):  
Magnetic Beads ◽  
Spin Valve ◽  
Magnetic Bead ◽  
Highly Sensitive ◽  
Magnetic Spin ◽  
Biosensor Application ◽  
Detection Of Biomolecules ◽  
Meander Line ◽  
Cross Type ◽  
Line Type

AbstractWe have demonstrated the use of highly sensitive spin valve sensors for the detection of micron magnetic beads. By using a ring type, cross type, and meander line type sensors, we were able to detect the presence of 2.8 μm size magnetic beads in real time by direct measurement of magnetic dipole fields from magnetic beads. The sensitivity of the ring, cross and meander line sensors were obtained about 50 μV/Oe, 7 μV/Oe, 30 μV/Oe and sensor output signals of 50 μV , 30 μV, 90 μV were obtained in an external applied field of 10 Oe and 1 mA sense current. Our results shows that ring, cross, and meander line shape spin valve sensors are very promising candidates for the detection of biomolecules with magnetic labels.

On chip cell separator using magnetic bead-based enrichment and depletion of various surface markers

2008 ◽  
Vol 11 (2) ◽  
pp. 509-515 ◽  
Author(s):  
Matthew D. Estes ◽  
Jaephil Do ◽  
Chong H. Ahn
Keyword(s):  
Magnetic Bead ◽  
Surface Markers ◽  
Cell Separator ◽  
On Chip

SENSING AND ACTUATING BIO-MATERIALS ON STANDARD CMOS SUBSTRATES

2013 ◽  
Vol 22 (02) ◽  
pp. 1250081 ◽  
Author(s):  
FAISAL T. ABU-NIMEH ◽  
FATHI M. SALEM
Keyword(s):  
High Speed ◽  
High Efficiency ◽  
Low Cost ◽  
Magnetic Bead ◽  
Column Switching ◽  
Parallel Operation ◽  
Coil Array ◽  
Lab On Chip ◽  
On Chip ◽  
Array Sensing

We present a low-cost, low-power, high efficiency, and portable integrated implementations of a lab-on-chip for magnetic molecular level sensing manipulation, and diagnosis. The design features an all-integrated programmable magnetic coil array for sensing and actuating small magnetic bead objects. The coil array is selectively and dynamically controlled using the smallest permissible vertical coil inductors in this technology. Each cell, composed of the coil and its logical control circuitry, can detect small objects in the order of 1 μm diameter as well as emit eight programmable magnetic field levels for manipulation. All array sensing and driving components are shared to reduce the overall imprint. They are tuned towards the 900 s MHz ISM band and incorporating high-speed serial row/column switching up to 40 MHz for seamless pseudo-parallel operation.

scholarly journals Optimization of planar Hall effect sensor for magnetic bead detection using spin-valve NiFe/Cu/NiFe/IrMn structures

2009 ◽  
Vol 187 ◽  
pp. 012056 ◽  
Author(s):  
Bui Dinh Tu ◽  
Le Viet Cuong ◽  
Do Thi Huong Giang ◽  
Tran Mau Danh ◽  
Nguyen Huu Duc
Keyword(s):  
Hall Effect ◽  
Spin Valve ◽  
Magnetic Bead ◽  
Planar Hall Effect ◽  
Hall Effect Sensor

A simple and portable device for the quantification of TNF-α in human plasma by means of on-chip magnetic bead-based proximity ligation assay

2014 ◽  
Vol 54 ◽  
pp. 499-505 ◽  
Author(s):  
Vanessa Castro-López ◽  
Jorge Elizalde ◽  
Marcin Pacek ◽  
Elizabeth Hijona ◽  
Luis Bujanda
Keyword(s):  
Human Plasma ◽  
Magnetic Bead ◽  
Portable Device ◽  
Proximity Ligation Assay ◽  
Proximity Ligation ◽  
Tnf Α ◽  
On Chip
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