300 MHz continuous wave electron paramagnetic resonance spectrometer for small animal in vivo imaging

2000 ◽  
Vol 71 (11) ◽  
pp. 4273 ◽  
Author(s):  
J. Koscielniak ◽  
N. Devasahayam ◽  
M. S. Moni ◽  
P. Kuppusamy ◽  
K. Yamada ◽  
...  
Keyword(s):  
Electron Paramagnetic Resonance ◽  
In Vivo Imaging ◽  
Continuous Wave ◽  
Small Animal ◽  
Electron Paramagnetic Resonance Spectrometer ◽  
Paramagnetic Resonance ◽  
Electron Paramagnetic

Evaluation and Comparison of Pulsed and Continuous Wave Radiofrequency Electron Paramagnetic Resonance Techniques for in Vivo Detection and Imaging of Free Radicals

2002 ◽  
Vol 154 (2) ◽  
pp. 287-297 ◽  
Author(s):  
Ken-Ichi Yamada ◽  
Ramachandran Murugesan ◽  
Nallathamby Devasahayam ◽  
John A. Cook ◽  
James B. Mitchell ◽  
...  
Keyword(s):  
Electron Paramagnetic Resonance ◽  
Free Radicals ◽  
Continuous Wave ◽  
Paramagnetic Resonance ◽  
In Vivo Detection ◽  
Electron Paramagnetic

A 1–2 GHz pulsed and continuous wave electron paramagnetic resonance spectrometer

1996 ◽  
Vol 67 (7) ◽  
pp. 2514-2527 ◽  
Author(s):  
Richard W. Quine ◽  
George A. Rinard ◽  
Barnard T. Ghim ◽  
Sandra S. Eaton ◽  
Gareth R. Eaton
Keyword(s):  
Electron Paramagnetic Resonance ◽  
Continuous Wave ◽  
Electron Paramagnetic Resonance Spectrometer ◽  
Paramagnetic Resonance ◽  
Electron Paramagnetic

scholarly journals Brain Redox Imaging Using In Vivo Electron Paramagnetic Resonance Imaging and Nitroxide Imaging Probes

2019 ◽  
Vol 5 (1) ◽  
pp. 11 ◽  
Author(s):  
Hirotada Fujii ◽  
Miho Emoto ◽  
Hideo Sato-Akaba
Keyword(s):  
Electron Paramagnetic Resonance ◽  
Oxidative Damage ◽  
Continuous Wave ◽  
Redox Status ◽  
Imaging Systems ◽  
Paramagnetic Resonance ◽  
Specific Distribution ◽  
Imaging Probes ◽  
Electron Paramagnetic

Reactive oxygen species (ROS) are produced by living organisms as a result of normal cellular metabolism. Under normal physiological conditions, oxidative damage is prevented by the regulation of ROS by the antioxidant network. However, increased ROS and decreased antioxidant defense may contribute to many brain disorders, such as stroke, Parkinson’s disease, and Alzheimer’s disease. Noninvasive assessment of brain redox status is necessary for monitoring the disease state and the oxidative damage. Continuous-wave electron paramagnetic resonance (CW-EPR) imaging using redox-sensitive imaging probes, such as nitroxides, is a powerful method for visualizing the redox status modulated by oxidative stress in vivo. For conventional CW-EPR imaging, however, poor signal-to-noise ratio, low acquisition efficiency, and lack of anatomic visualization limit its ability to achieve three-dimensional redox mapping of small rodent brains. In this review, we discuss the instrumentation and coregistration of EPR images to anatomical images and appropriate nitroxide imaging probes, all of which are needed for a sophisticated in vivo EPR imager for all rodents. Using new EPR imaging systems, site-specific distribution and kinetics of nitroxide imaging probes in rodent brains can be obtained more accurately, compared to previous EPR imaging systems. We also describe the redox imaging studies of animal models of brain disease using newly developed EPR imaging.

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