paramagnetic probe
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2019 ◽  
Vol 151 ◽  
pp. 104256 ◽  
Author(s):  
Alessia Artesani ◽  
Laurent Binet ◽  
Francesca Tana ◽  
Daniela Comelli ◽  
Luigi De Nardo ◽  
...  

2019 ◽  
Vol 5 (5-6) ◽  
pp. 244-253
Author(s):  
Zhou Gong ◽  
Shuai Yang ◽  
Qing-Fen Yang ◽  
Yue-Ling Zhu ◽  
Jing Jiang ◽  
...  

AbstractNMR structure calculation is inherently integrative, and can incorporate new experimental data as restraints. As RNAs have lower proton densities and are more conformational heterogenous than proteins, the refinement of RNA structures can benefit from additional types of restraints. Paramagnetic relaxation enhancement (PRE) provides distance information between a paramagnetic probe and protein or RNA nuclei. However, covalent conjugation of a paramagnetic probe is difficult for RNAs, thus limiting the use of PRE NMR for RNA structure characterization. Here, we show that the solvent PRE can be accurately measured for RNA labile imino protons, simply with the addition of an inert paramagnetic cosolute. Demonstrated on three RNAs that have increasingly complex topologies, we show that the incorporation of the solvent PRE restraints can significantly improve the precision and accuracy of RNA structures. Importantly, the solvent PRE data can be collected for RNAs without isotope enrichment. Thus, the solvent PRE method can work integratively with other biophysical techniques for better characterization of RNA structures.


2019 ◽  
Vol 4 (436) ◽  
pp. 32-35
Author(s):  
A.S. Bukanova ◽  
◽  
F.B. Kairlieva ◽  
L.B. Sakipova ◽  
N.A. Karabasova ◽  
...  

ChemMedChem ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. 603-612
Author(s):  
Mansura Akter ◽  
Nyssa Drinkwater ◽  
Shane M. Devine ◽  
Simon C. Drew ◽  
Bankala Krishnarjuna ◽  
...  

2018 ◽  
Vol 49 (4) ◽  
pp. 403-413 ◽  
Author(s):  
A. A. Akovantseva ◽  
V. N. Bagratashvili ◽  
N. A. Chumakova ◽  
E. N. Golubeva ◽  
O. I. Gromov ◽  
...  

2017 ◽  
Vol 170 ◽  
pp. 202-208
Author(s):  
Leah M. Seebald ◽  
Christopher M. DeMott ◽  
Srivathsan Ranganathan ◽  
Papa Nii Asare-Okai ◽  
Anastasia Glazunova ◽  
...  

2017 ◽  
Vol 381 (16) ◽  
pp. 1445-1448 ◽  
Author(s):  
G.P. Berman ◽  
V.N. Gorshkov ◽  
V.I. Tsifrinovich

2017 ◽  
Vol 56 (7) ◽  
pp. 3773-3780 ◽  
Author(s):  
Leah M. Seebald ◽  
Christopher M. DeMott ◽  
Srivathsan Ranganathan ◽  
Papa Nii Asare Okai ◽  
Anastasia Glazunova ◽  
...  

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