Pharmacological Effects of Urinary Products Obtained after Treatment with Saiboku-To, a Herbal Medicine for Bronchial Asthma, on Type IV Allergic Reaction

Planta Medica ◽  
2000 ◽  
Vol 66 (7) ◽  
pp. 607-611 ◽  
Author(s):  
Chizu Taniguchi ◽  
Masato Homma ◽  
Osamu Takano ◽  
Toshihiko Hirano ◽  
Kitaro Oka ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Allergic Reaction ◽  
Bronchial Asthma ◽  
Pharmacological Effects ◽  
Type Iv

scholarly journals Uji Toksisitas Akut Ekstrak Etanol Daun Sapu Jagad (Isotoma longiflora (L) Presl.) pada Mencit Galur Mus muculus

2017 ◽  
Vol 4 (1) ◽  
pp. 42
Author(s):  
Ira Safitri ◽  
Inayah Inayah
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Herbal Medicine ◽  
Acute Toxicity ◽  
Lethal Dose ◽  
Clinical Signs ◽  
Probit Analysis ◽  
Acute Toxicity Test ◽  
Pharmacological Effects ◽  
Per Oral

Sapu Jagad (Isotoma longiflora (L) Presl.) plant has been empirically used as traditional medicine. Some studies showthat this plant has pharmacological effects as antibiotic, anticancer, and analgetic. It is of importance to conduct studyin finding out the safetiness of this plant as herbal medicine. Therefore, we conducted study to find out lethal dose ofits leaves on mice (Mus muculus) using acute toxicity test. Several doses have been given to certain groups to find outits effect including death. The extract has been given one time per oral. Then, we recorded the clinical signs and deathof mice until 14 days. The data was analyzed using probit analysis to measure LD50. This study shows that ethanolextract of Sapu Jagad leaves has LD50 12.610 mg/kgBW and toxicity of central nervous system proven by seizureending with death. As conclusion, this extract has toxicity especially to central nervous system.

Studies on treating eczema by Chinese herbal medicine with anti-type IV allergic activity

2001 ◽  
Vol 7 (1) ◽  
pp. 7-11
Author(s):  
Xi-ran Lin ◽  
Cai-xia Tu ◽  
Xian-min Meng ◽  
Chun-mei Yang ◽  
Ming-yang Gao ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Type Iv

scholarly journals Review of Compounds and Pharmacological Effects of Delphinium

2020 ◽  
Vol 2020 ◽  
pp. 1-23
Author(s):  
Sitan Chen ◽  
Lijun Meng ◽  
Fatma M. El-Demerdash ◽  
Li Zhou ◽  
Syed Arif Hussian Rizvi ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Bioactive Compounds ◽  
Pharmacological Effects

Plants of Delphinium are herbal medicine used in the Tibet region with whole grass as a drug, which have the effects of analgesic, antibacterial, antipyretic, and anticancer. The main bioactive compounds are alkaloids, flavonoids, and sterols. This review summarized the compounds and pharmacological effects of Delphinium and provides a reference for further research on Delphinium.

scholarly journals A case of immunoglobulin M nephropathy with worsened proteinuria associated with type IV allergic reaction to hydroxypropyl cellulose

2018 ◽  
Vol 31 (1) ◽  
pp. 51-56
Author(s):  
Hiroaki Kanai ◽  
Emi Sawanobori ◽  
Anna Kobayashi ◽  
Miwa Goto ◽  
Kosuke Higashida ◽  
...  
Keyword(s):  
Allergic Reaction ◽  
Hydroxypropyl Cellulose ◽  
Immunoglobulin M ◽  
Type Iv

Cholinergic variant of infectious allergic bronchial asthma

1986 ◽  
Vol 67 (5) ◽  
pp. 352-354
Author(s):  
A. D. Ado ◽  
R. M. Zolotareva
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Allergic Reaction ◽  
Bronchial Asthma ◽  
Inflammatory Diseases ◽  
Bronchial Tree ◽  
Decay Products ◽  
Sensitization Process ◽  
Chronic Pneumonia ◽  
Allergic Bronchial Asthma

Infectious and allergic bronchial asthma occurs on the basis of inflammatory diseases: acute and chronic pneumonia, influenza, bronchitis, pathology of ENT organs. Bacteria, toxins, decay products of own tissues cause sensitization process and subsequent allergic reaction, which is localized in the tissues of the bronchial tree, involves primarily the peripheral structures of the autonomic nervous system and can cause increased excitability of the parasympathetic department.

Eczematous infiltrated plaques to subcutaneous heparin: a type IV allergic reaction

2006 ◽  
Vol 123 (4) ◽  
pp. 507-514 ◽  
Author(s):  
A.J. BIRCHER ◽  
R. FLÜCKIGER ◽  
S.A. BUCHNER
Keyword(s):  
Allergic Reaction ◽  
Type Iv ◽  
Subcutaneous Heparin

scholarly journals Proteomic Analysis of Anti-inflammatory Effects of a Kampo (Japanese Herbal) Medicine “Shoseiryuto (Xiao-Qing-Long-Tang)” on Airway Inflammation in a Mouse Model

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Takayuki Nagai ◽  
Marino Nakao ◽  
Yuliko Shimizu ◽  
Yoshio Kodera ◽  
Masamichi Oh-Ishi ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Mouse Model ◽  
Airway Inflammation ◽  
Bronchial Asthma ◽  
Antibody Titer ◽  
Lung Tissue ◽  
Proteomic Analysis ◽  
Allergic Airway Inflammation ◽  
Airway Hyperreactivity ◽  
Japanese Herbal Medicine

Effects of a Kampo (Japanese herbal) medicine “shoseiryuto (SST, xiao-qing-long-tang in Chinese)”, which has been used for the treatment of allergic bronchial asthma clinically, were examined on ovalbumin (OVA)-sensitized allergic airway inflammation model (i.e., bronchial asthma) in a mouse. When SST was orally administered at 0.5 g kg−1 day−1from day 1 to 6 after OVA inhalation, SST reduced the inflammation in lung tissue, the number of eosinophils and the OVA-specific immunoglobulin E (IgE) antibody titer in bronchoalveolar lavage (BAL) fluids at 7 days after the OVA inhalation. SST also reduced the airway hyperreactivity at 6 days after the OVA inhalation. Proteomic analysis with the agarose two-dimensional electrophoresis showed that the expression of spectrin α2 was reduced in the lung tissue of OVA-sensitized mice and SST recovered the expression. Western blot and immunohistochemical analyses of lung tissue also confirmed this result. When prednisolone was orally administered at 3 mg kg−1 day−1from day 1 to 6 after OVA inhalation, the inflammation in lung tissue, the number of eosinophils in BAL fluids and airway hyperreactivity were reduced in the OVA-sensitized mice. However, prednisolone did not reduce the OVA-specific IgE antibody titer in BAL fluids and did not recover the expression of spectrin α2 in lung tissue. These results suggest that at least a part of action mechanism of SST against OVA-sensitized allergic airway inflammation in a mouse model is different from that of prednisolone.

scholarly journals Phytoneering drugs for the treatment of cough: ways to provide the rational herbal medicine

2021 ◽  
Vol 25 (1) ◽  
pp. 24-31
Author(s):  
T.S. Sakharova ◽  
K.O. Zupanets ◽  
I.A. Otrishko ◽  
N.P. Bezugla ◽  
K.L. Ratushna
Keyword(s):  
Herbal Medicine ◽  
Respiratory Tract ◽  
Prescription Drugs ◽  
Herbal Product ◽  
Biologically Active ◽  
Pharmacological Effects ◽  
Self Medication ◽  
Herbal Products ◽  
Important Place ◽  
Optimal Drug

Diseases of the respiratory system occupy an important place in the structure of morbidity in the population of Ukraine, being only second to diseases of the cardiovascular system in prevalence. Patients with a respiratory pathology make up a significant part of the pharmacy visitors. In most cases, at the first symptoms of such diseases, patients begin to be treated on their own with the help of non-prescription drugs, and quite often the first person they turn to is a pharmacist. A striking example of the effectiveness and safety of herbal medicine is the symptomatic treatment of cough as one of the most characteristic symptoms of the respiratory tract pathology. The use of herbal products with the antitussive, expectorant, mucolytic action has a long history, and currently it does not lose its significance. The clinical efficacy of herbal products is determined by the mechanism of their specific action, and the rational choice of the optimal drug taking into account the cause of the cough, its nature and the characteristics of the course of the inflammatory process in the respiratory organs, allows eliminating cough or effectively managing it. Bronchipret® is a herbal product of “Bionorica SE” company, which is one of the most studied and widely used in medical practice. The drug is indicated for the treatment of respiratory tract diseases accompanied by cough and sputum formation, including acute and chronic bronchitis. The main and well-studied pharmacological effects of Bronchipret® are secretolytic/mucolytic, anti-inflammatory, antiviral, antimicrobial and bronchospasmolytic ones. The pharmacological effects listed are due to a complex of biologically active substances (BAS) of such plants as the root of spring primrose, thyme herb, ivy leaf. All medicinal plants that make up the “active core” of the drug have a long history of their use in folk medicine. Moreover, their various beneficial effects on the human body in different diseases and conditions have been confirmed by empirical experience. The drug is produced in three dosage forms (drops, syrup, tablets), and it determines the targeting of its prescription to different categories of patients. The drug has a high evidence base and has been studied at the cellular and molecular levels. Conclusions. In the case of choosing a herbal medicine for responsible self-medication, drug consumers can rely on their own experience, but most of them trust the knowledge of a pharmaceutical professional, and this fact increases the pharmacist’s responsibility for the treatment prescribed. Therefore, it should be the choice of a drug with an optimal efficacy/safety ratio, which is determined from the standpoint of evidence-based medicine. It is precisely these requirements that the phytoneering drug Bronchipret® meets.

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