57-jährige Patientin mit ungewöhnlicher Häufung infektiöser Hauterkrankungen

2019 ◽  
Vol 46 (03) ◽  
pp. 108-113
Author(s):  
D. Niebel ◽  
C. Schwarze-Zander ◽  
T. Bieber
Keyword(s):  
Candida Albicans ◽  
Herpes Simplex Virus ◽  
Herpes Zoster ◽  
Herpes Simplex ◽  
Antiretrovirale Therapie ◽  
Single Tablet Regimen ◽  
Hiv Test ◽  
Simplex Virus

ZusammenfassungAufgrund des ungewöhnlichen Befundes mehrerer gleichzeitig vorliegender infektiöser dermatologischer Krankheitsbilder wurde bei einer 57-jährigen Patientin eine HIV-Infektion diagnostiziert. Neben der spezifischen antiinfektiösen Therapie gegen nachgewiesene Erreger (Candida albicans und Herpes-simplex-Virus) führte die prompt eingeleitete antiretrovirale Therapie zu einer Senkung der Viruslast unterhalb der Nachweisgrenze und zur Stabilisierung des Immunstatus. Jede nachgewiesene HIV-Infektion sollte behandelt werden; eine sofortiger Behandlungsbeginn aller HIV-positiven Personen kann dazu beitragen, Neuinfektionen einzudämmen. Die moderne antivirale Kombinationstherapie mit „Single Tablet Regimen“ und geringer Nebenwirkungsrate hat deutlich zur Adhärenz beigetragen. Bei Auftreten von dermatologischen Indikatorenerkrankungen wie z. B. oraler Kandidose, Herpes zoster oder schwerer Psoriasis sollte ein HIV-Test durchgeführt werden.

Effect of a combination therapy between IL-12 and soluble IL-4 receptor (sIL-4R) onCandida albicansand herpes simplex virus type 1 infections in thermally injured mice

2002 ◽  
Vol 48 (10) ◽  
pp. 886-894 ◽  
Author(s):  
Makiko Kobayashi ◽  
Hitoshi Takahashi ◽  
David N Herndon ◽  
Richard B Pollard ◽  
Fujio Suzuki
Keyword(s):  
T Cells ◽  
Candida Albicans ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Herpes Simplex Virus Type ◽  
Cell Responses ◽  
Ifn Γ ◽  
Simplex Virus ◽  
Hsv 1

The effectiveness of a combination using IL-12 and soluble IL-4 receptor (sIL-4R) to treat severe infections of herpes simplex virus type 1 (HSV-1) and Candida albicans in thermally injured mice was investigated. Although sIL-4R decreased burn-associated type 2 T-cell responses, the effect of sIL-4R was minimal on the morbidity and mortality of thermally injured mice exposed to 250 times LD50of HSV-1 or 10 times LD50of C. albicans. Compared with 100% mortality in control mice, mortality for HSV-1 and C. albicans was 40 and 20%, respectively, in thermally injured mice that received IL-12 and sIL-4R in combination. After stimulation with anti-CD3 monoclonal antibody, splenic T cells from thermally injured mice exposed to large amounts of HSV-1 or C. albicans did not produce gamma interferon (IFN-γ) into their culture fluids. However, IFN-γ was produced by splenic T cells from thermally injured and infected mice treated with IL-12 and sIL-4R in combination. These results suggest that therapeutic treatment with a combination of IL-12 and sIL-4R may be effective by inducing type 1 T-cell responses in thermally injured mice exposed to large amounts of HSV-1 or C. albicans.Key words: burn, IL-12, soluble IL-4 receptor, herpesvirus, Candida albicans.

Herpes simplex virus,Candida albicans and mouth ulcers in neutropenic patients with non-haematological malignancy

1989 ◽  
Vol 25 (1) ◽  
pp. 75-76 ◽  
Author(s):  
Gerald Beattie ◽  
Jennifer Whelan ◽  
James Cassidy ◽  
Leslie Milne ◽  
Sheila Burns ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Haematological Malignancy ◽  
Neutropenic Patients ◽  
Simplex Virus

scholarly journals A retrospective study of the prevalence of herpes simplex virus and herpes zoster virus infection

2014 ◽  
Vol 26 (2) ◽  
Author(s):  
Maryam Radzuan ◽  
Irna Sufiawati ◽  
Dendi Sandiono
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Zoster ◽  
Herpes Simplex ◽  
Head And Neck ◽  
Systemic Diseases ◽  
Herpes Viruses ◽  
Virus Family ◽  
Blood Disorder ◽  
Herpes Zoster Virus ◽  
Simplex Virus

Introduction: Herpes simplex virus (HSV) and herpes zoster virus (HZV) are two members of the herpes virus family that can manifest in oral mucosa. Following primary infection, the viruses remain latent and may reactivate if the immune system becomes compromised. The purpose of this study was to know the prevalence and the site of manifestation of HSV and HZV infection in RSUP Hasan Sadikin Bandung from January 2007 until December 2011. Method: The method of this study was descriptive retrospective using secondary data and literature study. Data were taken from medical records of patients in RSUP Hasan Sadikin Bandung, from January 2007 until December 2011. The results were then presented in table and graphs. Result: The study’s result showed the prevalence of HSV infection from 2007-2011 was 6% while the prevalence of HZV infection was 46%. HSV and HZV infection occurred 41% at head and neck, 36% at trunk, 13% at extremities, 7% generalized, and 3% unspecified. The systemic diseases involved in these herpes viruses found in 20.3% patients. Conclusion: The conclusion of this study were the prevalence of HSV infection was low, while the prevalence of HZV infection was high. HSV infection frequently affected at head and neck, and HZV infection frequently affected the trunk. Systemic diseases involved in these herpes viruses were malignancies, neoplasm, internal organ disorders, skin diseases, blood disorder, and nerve disorder.

scholarly journals What is the True Etiology of “Recurrent Shingles”?

2021 ◽  
Vol 5 (1) ◽  
pp. 7-12
Author(s):  
Ramya Vangipuram ◽  
Harrison Nguyen ◽  
Stephen Tyring
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Zoster ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Varicella Zoster ◽  
Dermatology Clinic ◽  
Simplex Infection ◽  
Common Diagnosis ◽  
Recurrent Herpes ◽  
Simplex Virus

Purpose:  To determine the true etiology of cases of putative recurrent shingles referred to a dermatology clinic. Methods: A prospective cohort study of patients aged 15-87 years with reported recurrent herpes zoster was conducted. Vesicular fluid and serology for herpes simplex 1, 2, and varicella zoster virus immunoglobulins were obtained from patients presenting with vesicles. Biopsies were obtained from patients with ambiguous presentations. Results:  44 patients (56%) had evidence of herpes simplex virus infection. 32% of patients had positive herpes simplex virus cultures or polymerase chain reaction sequencing, and 24% additional patients were diagnosed with presumptive simplex infection based on elevated antibody titers. 44% of patients had a diagnosis other than zoster or simplex. One individual had a positive viral culture for varicella zoster virus. 99% of patients who presented with suspected recurrent herpes zoster had no definitive evidence of varicella zoster virus reactivation. Conclusions:  The most common diagnosis was herpes simplex infection. Our results suggest that true recurrent shingles in immunocompetent patients is rare.

Infectious Diseases of the Esophagus

2018 ◽  
Author(s):  
Wai-Kit Lo
Keyword(s):  
Candida Albicans ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Infectious Diseases ◽  
Hematologic Malignancies ◽  
Esophageal Mucosa ◽  
Esophageal Candidiasis ◽  
Treatment Regimens ◽  
Candida Esophagitis ◽  
Simplex Virus

This review considers the three most common infectious diseases affecting the esophageal mucosa: Candida organisms (particularly Candida albicans), cytomegalovirus (CMV), and herpes simplex virus (HSV), including their epidemiologies, pathogeneses, diagnoses, differentials, managements, complications, and prognoses. Infection is often indicated by the symptom of odynophagia, although more general gastrointestinal complaints such as dysphagia and heartburn can also be present. Esophageal candidiasis caused by C. albicans is the most common esophageal infection, detected in immunocompetent patients, as well as those with HIV infection, hematologic malignancies, or other immunologic disorders. Treatment of these diseases should target the fungal or viral pathogens involved using systemically active antibiotic regimens. As infectious esophagitis is frequently seen in immunocompromised hosts, assessment for HIV and malignancy should be considered with a new diagnosis. Figures show endoscopic images of Candida esophagitis and HSV esophagitis. Tables list risk factors for infectious esophagitis, possible symptoms of infectious esophagitis, pathogens causing infectious esophagitis and distinguishing characteristics, the Kodsi classification of Candida esophagitis severity on endoscopy, and treatment regimens for esophageal candidiasis,  CMV esophagitis in HIV/AIDS patients, and HSV esophagitis. This review contains ­2 highly rendered figures, 8 tables, 38 references. Key words: Candida albicans, Cytomegalovirus (CMV), Herpes simplex virus (HSV), HIV Complications, Immunosuppression Treatment for Candida, CMV, and HSV, Infections of the esophagus

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