Herpes simplex virus,Candida albicans and mouth ulcers in neutropenic patients with non-haematological malignancy

1989 ◽  
Vol 25 (1) ◽  
pp. 75-76 ◽  
Author(s):  
Gerald Beattie ◽  
Jennifer Whelan ◽  
James Cassidy ◽  
Leslie Milne ◽  
Sheila Burns ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Haematological Malignancy ◽  
Neutropenic Patients ◽  
Simplex Virus

Effect of a combination therapy between IL-12 and soluble IL-4 receptor (sIL-4R) onCandida albicansand herpes simplex virus type 1 infections in thermally injured mice

2002 ◽  
Vol 48 (10) ◽  
pp. 886-894 ◽  
Author(s):  
Makiko Kobayashi ◽  
Hitoshi Takahashi ◽  
David N Herndon ◽  
Richard B Pollard ◽  
Fujio Suzuki
Keyword(s):  
T Cells ◽  
Candida Albicans ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Herpes Simplex Virus Type ◽  
Cell Responses ◽  
Ifn Γ ◽  
Simplex Virus ◽  
Hsv 1

The effectiveness of a combination using IL-12 and soluble IL-4 receptor (sIL-4R) to treat severe infections of herpes simplex virus type 1 (HSV-1) and Candida albicans in thermally injured mice was investigated. Although sIL-4R decreased burn-associated type 2 T-cell responses, the effect of sIL-4R was minimal on the morbidity and mortality of thermally injured mice exposed to 250 times LD50of HSV-1 or 10 times LD50of C. albicans. Compared with 100% mortality in control mice, mortality for HSV-1 and C. albicans was 40 and 20%, respectively, in thermally injured mice that received IL-12 and sIL-4R in combination. After stimulation with anti-CD3 monoclonal antibody, splenic T cells from thermally injured mice exposed to large amounts of HSV-1 or C. albicans did not produce gamma interferon (IFN-γ) into their culture fluids. However, IFN-γ was produced by splenic T cells from thermally injured and infected mice treated with IL-12 and sIL-4R in combination. These results suggest that therapeutic treatment with a combination of IL-12 and sIL-4R may be effective by inducing type 1 T-cell responses in thermally injured mice exposed to large amounts of HSV-1 or C. albicans.Key words: burn, IL-12, soluble IL-4 receptor, herpesvirus, Candida albicans.

Infectious Diseases of the Esophagus

2018 ◽  
Author(s):  
Wai-Kit Lo
Keyword(s):  
Candida Albicans ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Infectious Diseases ◽  
Hematologic Malignancies ◽  
Esophageal Mucosa ◽  
Esophageal Candidiasis ◽  
Treatment Regimens ◽  
Candida Esophagitis ◽  
Simplex Virus

This review considers the three most common infectious diseases affecting the esophageal mucosa: Candida organisms (particularly Candida albicans), cytomegalovirus (CMV), and herpes simplex virus (HSV), including their epidemiologies, pathogeneses, diagnoses, differentials, managements, complications, and prognoses. Infection is often indicated by the symptom of odynophagia, although more general gastrointestinal complaints such as dysphagia and heartburn can also be present. Esophageal candidiasis caused by C. albicans is the most common esophageal infection, detected in immunocompetent patients, as well as those with HIV infection, hematologic malignancies, or other immunologic disorders. Treatment of these diseases should target the fungal or viral pathogens involved using systemically active antibiotic regimens. As infectious esophagitis is frequently seen in immunocompromised hosts, assessment for HIV and malignancy should be considered with a new diagnosis. Figures show endoscopic images of Candida esophagitis and HSV esophagitis. Tables list risk factors for infectious esophagitis, possible symptoms of infectious esophagitis, pathogens causing infectious esophagitis and distinguishing characteristics, the Kodsi classification of Candida esophagitis severity on endoscopy, and treatment regimens for esophageal candidiasis,  CMV esophagitis in HIV/AIDS patients, and HSV esophagitis. This review contains ­2 highly rendered figures, 8 tables, 38 references. Key words: Candida albicans, Cytomegalovirus (CMV), Herpes simplex virus (HSV), HIV Complications, Immunosuppression Treatment for Candida, CMV, and HSV, Infections of the esophagus

57-jährige Patientin mit ungewöhnlicher Häufung infektiöser Hauterkrankungen

2019 ◽  
Vol 46 (03) ◽  
pp. 108-113
Author(s):  
D. Niebel ◽  
C. Schwarze-Zander ◽  
T. Bieber
Keyword(s):  
Candida Albicans ◽  
Herpes Simplex Virus ◽  
Herpes Zoster ◽  
Herpes Simplex ◽  
Antiretrovirale Therapie ◽  
Single Tablet Regimen ◽  
Hiv Test ◽  
Simplex Virus

ZusammenfassungAufgrund des ungewöhnlichen Befundes mehrerer gleichzeitig vorliegender infektiöser dermatologischer Krankheitsbilder wurde bei einer 57-jährigen Patientin eine HIV-Infektion diagnostiziert. Neben der spezifischen antiinfektiösen Therapie gegen nachgewiesene Erreger (Candida albicans und Herpes-simplex-Virus) führte die prompt eingeleitete antiretrovirale Therapie zu einer Senkung der Viruslast unterhalb der Nachweisgrenze und zur Stabilisierung des Immunstatus. Jede nachgewiesene HIV-Infektion sollte behandelt werden; eine sofortiger Behandlungsbeginn aller HIV-positiven Personen kann dazu beitragen, Neuinfektionen einzudämmen. Die moderne antivirale Kombinationstherapie mit „Single Tablet Regimen“ und geringer Nebenwirkungsrate hat deutlich zur Adhärenz beigetragen. Bei Auftreten von dermatologischen Indikatorenerkrankungen wie z. B. oraler Kandidose, Herpes zoster oder schwerer Psoriasis sollte ein HIV-Test durchgeführt werden.

scholarly journals Kinetics of <i>Candida albicans</i> and <i>Staphylococcus aureus</i> Biofilm Initiation on Herpes Simplex Virus (HSV-1 and HSV-2) Infected Cells

2020 ◽  
Vol 10 (11) ◽  
pp. 583-598
Author(s):  
Balbina J. Plotkin ◽  
Ira M. Sigar ◽  
Amber Kaminski ◽  
Jessica Kreamer ◽  
Brent Ito ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Candida Albicans ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Infected Cells ◽  
Simplex Virus ◽  
Kinetics Of ◽  
Hsv 1

Assembly of VP26 in herpes simplex virus-1 capsid implicated by 3-D structure of recombinant capsid

1995 ◽  
Vol 53 ◽  
pp. 840-841
Author(s):  
Z. Hong Zhou ◽  
Jing He ◽  
Joanita Jakana ◽  
J. D. Tatman ◽  
Frazer J. Rixon ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
3D Structure ◽  
Structure Study ◽  
Herpes Simplex Virus 1 ◽  
Shell Proteins ◽  
Life Threatening ◽  
Infected Cells ◽  
Simplex Virus ◽  
Hsv 1

Herpes simplex virus-1 (HSV-1) is a ubiquitous virus which is implicated in diseases ranging from self-curing cold sores to life-threatening infections. The 2500 Å diameter herpes virion is composed of a glycoprotein spike containing, lipid envelope, enclosing a protein layer (the tegument) in which is embedded the capsid (which contains the dsDNA genome). The B-, and A- and C-capsids, representing different morphogenetic stages in HSV-1 infected cells, are composed of 7, and 5 structural proteins respectively. The three capsid types are organized in similar T=16 icosahedral shells with 12 pentons, 150 hexons, and 320 connecting triplexes. Our previous 3D structure study at 26 Å revealed domain features of all these structural components and suggested probable locations for the outer shell proteins, VP5, VP26, VP19c and VP23. VP5 makes up most of both pentons and hexons. VP26 appeared to bind to the VP5 subunit in hexon but not to that in penton.

Application of EM to differentiate herpes virus from pox virus in genital specimens

1994 ◽  
Vol 52 ◽  
pp. 262-263
Author(s):  
K. Rekrut ◽  
K. Schleuter
Keyword(s):  
Tissue Culture ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Fresh Tissue ◽  
Culture Cells ◽  
Viral Transport ◽  
Carbon Coated ◽  
Immuno Assay ◽  
Simplex Virus ◽  
Enzyme Immuno Assay

Confirmation of herpes simplex virus (HSV) from genital lesions of obstetrical (OB) patients may affect both the management of the delivery and of the neonate.(l,2) During 1992 and 1993, 4,450 genital specimens from OB patients were submitted in viral transport media for herpes culture. The specimens were inoculated into MRC-5, Vero, and A-549 tissue culture tubes, incubated, and examined daily for 7 days for cytopathic effect (CPE). The original specimens were frozen at −70° C until final reports were issued. Culture tubes with CPE were tested by the Dupont Herpchek enzyme immuno assay (EIA) to confirm the presence of herpes simplex virus (HSV). (3,4) 170 OB patient specimens were positive by culture and confirmed by EIA.There were also 63 cultures exhibiting CPE ressembling HSV which were negative by EIA testing, which failed to pass in fresh tissue culture cells or progress to more enhanced CPE in culture. These original specimens were screened by electron microscopy after direct ultracentrifugation employing the Beckman airfuge with the EM 90 rotor on to formvar carbon-coated 300 mesh copper grids and negatively stained with 2% PTA.

Sign in / Sign up

Export Citation Format

Share Document