Serum levels of insulin-like growth factor-1 in the three months following surgery for a hip fracture in elderly: relationship with nutritional status and inflammatory reaction

2000 ◽  
Vol 19 (5) ◽  
pp. 349-354 ◽  
Author(s):  
B. CAMPILLO ◽  
E. PAILLAUD ◽  
P.N. BORIES ◽  
M. NOEL ◽  
D. PORQUET ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Growth Factor ◽  
Nutritional Status ◽  
Inflammatory Reaction ◽  
Serum Levels ◽  
Insulin Like Growth Factor

scholarly journals The Insulin-Like Growth Factor System and Nutritional Assessment

Scientifica ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Callum Livingstone
Keyword(s):  
Growth Factor ◽  
Nutritional Status ◽  
Nutritional Support ◽  
Nutritional Assessment ◽  
Serum Levels ◽  
Clinical Findings ◽  
Insulin Like Growth Factor ◽  
Reactive Protein ◽  
Igf System ◽  
Health And Disease

Over recent years there has been considerable interest in the role of the insulin-like growth factor (IGF) system in health and disease. It has long been known to be dysregulated in states of under- and overnutrition, serum IGF-I levels falling in malnourished patients and responding promptly to nutritional support. More recently, other proteins in this system have been observed to be dysregulated in both malnutrition and obesity. Currently no biochemical marker is sufficiently specific for use in screening for malnutrition, but levels may be valuable in providing information on nutritional status and in monitoring of nutritional support. All have limitations as nutritional markers in that their serum levels are influenced by factors other than nutritional status, most importantly the acute phase response (APR). Levels should be interpreted along with clinical findings and the results of other investigations such as C-reactive protein (CRP). This paper reviews data supporting the use of proteins of the IGF system as nutritional markers.

scholarly journals Nutritional status of preschool Senegalese children: long-term effects of early severe malnutrition

2003 ◽  
Vol 90 (6) ◽  
pp. 1123-1132 ◽  
Author(s):  
Nicole Idohou-Dossou ◽  
Salimata Wade ◽  
Amadou T. Guiro ◽  
Cheikh S. Sarr ◽  
Babou Diaham ◽  
...  
Keyword(s):  
Growth Factor ◽  
Nutritional Status ◽  
Serum Levels ◽  
Fat Free Mass ◽  
Severe Malnutrition ◽  
Insulin Like Growth Factor ◽  
Long Term Effects ◽  
Biochemical Indicators ◽  
Igfbp 3

The prevalence of malnutrition remains high in many developing countries. However, data relating to the long-term effects of severe malnutrition, specifically, serum levels of biochemical indicators of nutritional status, are still scarce in the literature. Hence the present study aimed to investigate the nutritional, biological and growth status of Senegalese preschool children previously hospitalised for severe malnutrition. The study involved twenty-four 7-year-old children who had suffered from marasmus 5 years earlier, twenty-four siblings living in the same household, and nineteen age-matched children living in the centre of Dakar. The siblings were of similar age to the post-marasmic children. Anthropometry, serum biochemical indicators of nutritional status, growth factors, and haematological and mineral parameters were measured. The prevalence of stunting and wasting was the same in the post-marasmic children as in the siblings. Body-fat and fat-free-mass (FFM) deficits in both groups were corroborated by abnormally low concentrations of transthyretin, osteocalcin, insulin-like growth factor (IGF)-1, and insulin-like growth factor-binding protein (IGFBP)-3. FFM was positively and significantly correlated with concentrations of IGF-1 and IGFBP-3. In the post-marasmic children, height for age was also correlated with IGF-1. Of the post-marasmic children, 53 % had Fe-deficiency anaemia, as did 35 % of the siblings and 29 % of the controls. No significant associations were found between the serum concentrations of Ca, Cu, K, Mg, Na, P, Se, Zn and growth retardation. At 5 years after nutritional rehabilitation, the post-marasmic children remained stunted with nutritional indices significantly lower than the control children. However, these children were doing as well as their siblings except for minor infections.

Divergence between hepatic insulin-like growth factor (IGF)-I mRNA expression and IGF-I serum levels in Leishmania (Leishmania) infantum chagasi-infected dogs

2013 ◽  
Vol 151 (1-2) ◽  
pp. 163-167
Author(s):  
Flaviane A. Pinho ◽  
Nilton A. Magalhães ◽  
Kleverton R. Silva ◽  
Aline A. Carvalho ◽  
Fernando L.L. Oliveira ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mrna Expression ◽  
Leishmania Infantum ◽  
Serum Levels ◽  
Insulin Like Growth Factor ◽  
Igf I ◽  
Leishmania Infantum Chagasi

scholarly journals Role of Nutritional Status in the Regulation of Adrenarche1

1999 ◽  
Vol 84 (11) ◽  
pp. 3936-3944
Author(s):  
Thomas Remer ◽  
Friedrich Manz
Keyword(s):  
Growth Factor ◽  
Nutritional Status ◽  
Healthy Children ◽  
Insulin Like Growth Factor ◽  
Adrenal Androgen ◽  
Cross Sectional ◽  
Factor I ◽  
Growth Factor I ◽  
Excretion Rates

The factors regulating adrenarche are unknown. Recent in vitro studies have demonstrated that insulin and insulin-like growth factor I induce major adrenal steroidogenic enzyme genes and increase the production of adrenal androgens. Literature findings strongly suggest that changes in body mass index (BMI) reflect an integrated nonhormonal index of changes in serum levels and/or bioactivities of insulin and insulin-like growth factor I. We therefore longitudinally investigated individual changes in BMI and urinary 24-h excretion rates of dehydroepiandrosterone sulfate (DHEAS) in a prepuberty (PreC; n = 22, 11 boys and 11 girls) and a puberty (PubC; n = 20, 10 boys and 10 girls) cohort of healthy children. Twenty-four-hour urine samples were collected at yearly intervals during observation periods that lasted at least 4 yr (comprising ≥5 consecutive 24-h urine collections). For 4-yr intervals highly significant tracking coefficients (P < 0.001) of 0.73 (PreC) and 0.93 (PubC) were observed for DHEAS, emphasizing the importance of individual (and genetic) influences on adrenal androgen excretion. In both cohorts almost 3-fold higher median increases in urinary DHEAS excretion rates (P < 0.05) were observed during the 1-yr period of the individually highest rises in BMI compared with the 1-yr period of significantly lower rises in BMI (P < 0.01) in the same children after the factor age was controlled for. However, no consistently significant associations were found between urinary DHEAS output and BMI from simple cross-sectional correlations at defined age points. These findings provide the first in vivo evidence that a change in the nutritional status, measurable in the form of Δ-BMI (but not BMI alone), is an important physiological regulator of adrenarche regardless of individual adrenal androgen excretion level, age, and developmental stage.

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