The clinical importance and prognostic implications of microsatellite instability in sporadic cancer

2003 ◽  
Vol 29 (3) ◽  
pp. 201-212 ◽  
Author(s):  
D.A Lawes ◽  
S SenGupta ◽  
P.B Boulos
Keyword(s):  
Microsatellite Instability ◽  
Clinical Importance ◽  
Sporadic Cancer ◽  
Prognostic Implications

scholarly journals Microsatellite Instability and its Significance to Hereditary and Sporadic Cancer

10.5772/65065 ◽  
2016 ◽  
Author(s):  
Jeffery W. Bacher ◽  
Linda Clipson ◽  
Leta S. Steffen ◽  
Richard B. Halberg
Keyword(s):  
Microsatellite Instability ◽  
Sporadic Cancer

Prognostic implications ofBAX andTGFBRII mutations in colon cancers with microsatellite instability

2002 ◽  
Vol 35 (4) ◽  
pp. 368-371 ◽  
Author(s):  
Wade S. Samowitz ◽  
Karen Curtin ◽  
Susan Neuhausen ◽  
Donna Schaffer ◽  
Martha L. Slattery
Keyword(s):  
Microsatellite Instability ◽  
Colon Cancers ◽  
Prognostic Implications

scholarly journals Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0203051 ◽  
Author(s):  
Oscar Murcia ◽  
Míriam Juárez ◽  
María Rodríguez-Soler ◽  
Eva Hernández-Illán ◽  
Mar Giner-Calabuig ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Molecular Classification ◽  
Response To Chemotherapy ◽  
Prognostic Implications

Microsatellite instability in colorectal adenomas: relevance and clinical importance

2000 ◽  
Vol 15 (4) ◽  
pp. 189-196 ◽  
Author(s):  
Wolfgang M. Brueckl ◽  
Andreas Jung ◽  
Axel Wein ◽  
Thomas Brabletz ◽  
Klaus Guenther ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Clinical Importance ◽  
Colorectal Adenomas

Research Consumerism 101: Evaluating External Evidence of Treatment Effectiveness

2008 ◽  
Vol 17 (2) ◽  
pp. 43-49
Author(s):  
James L. Coyle
Keyword(s):  
Treatment Effectiveness ◽  
Code Of Ethics ◽  
Oropharyngeal Dysphagia ◽  
Clinical Importance ◽  
Professional Services ◽  
Adverse Outcomes ◽  
Professional Judgment ◽  
Evidence Based ◽  
Intervention Selection ◽  
Published Research

Abstract The modern clinician is a research consumer. Rehabilitation of oropharyngeal impairments, and prevention of the adverse outcomes of dysphagia, requires the clinician to select interventions for which evidence of a reasonable likelihood of a successful, important outcome exists. The purpose of this paper is to provide strategies for evaluation of published research regarding treatment of oropharyngeal dysphagia. This article utilizes tutorial and examples to inform and educate practitioners in methods of appraising published research. It provides and encourages the use of methods of efficiently evaluating the validity and clinical importance of published research. Additionally, it discusses the importance of the ethical obligation we, as practitioners, have to use evidence-based treatment selection methods and measurement of patient performance during therapy. The reader is provided with tactics for evaluating treatment studies to establish a study's validity and, thereby, objectively select interventions. The importance of avoiding subjective or unsubstantiated claims and using objective methods of generating empirical clinical evidence is emphasized. The ability to evaluate the quality of research provides clinicians with objective intervention selection as an important, essential component of evidence-based clinical practice. ASHA Code of Ethics (2003): Principle I, Rule F: “Individuals shall fully inform the persons they serve of the nature and possible effects of services rendered and products dispensed…” (p. 2) Principle I, Rule G: “Individuals shall evaluate the effectiveness of services rendered and of products dispensed and shall provide services or dispense products only when benefit can reasonably be expected.” (p. 2) Principle IV, Rule G: “Individuals shall not provide professional services without exercising independent professional judgment, regardless of referral source or prescription.” (p. 4)

Somatic hMLH3 frameshift mutation in colorectal cancers with microsatellite instability

2001 ◽  
Vol 120 (5) ◽  
pp. A295-A295
Author(s):  
D CHANG ◽  
A GOEL ◽  
L RICCIARDIELLO ◽  
C ARNOLD ◽  
C BOLAND
Keyword(s):  
Microsatellite Instability ◽  
Frameshift Mutation ◽  
Colorectal Cancers

Clinical importance of gallstones and p53 mutations in careinogenesis for gallbladder carcinoma

2001 ◽  
Vol 120 (5) ◽  
pp. A386-A386
Author(s):  
K HANADA ◽  
F HINO ◽  
H AMANO ◽  
H OOE ◽  
A HIRAMATSU ◽  
...  
Keyword(s):  
Gallbladder Carcinoma ◽  
Clinical Importance ◽  
P53 Mutations
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