Microsatellite instability in colorectal adenomas: relevance and clinical importance

2000 ◽  
Vol 15 (4) ◽  
pp. 189-196 ◽  
Author(s):  
Wolfgang M. Brueckl ◽  
Andreas Jung ◽  
Axel Wein ◽  
Thomas Brabletz ◽  
Klaus Guenther ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Clinical Importance ◽  
Colorectal Adenomas

scholarly journals Microsatellite instability in colorectal adenomas and hyperplastic polyps in Lynch syndrome

2011 ◽  
Vol 9 (Suppl 1) ◽  
pp. O4
Author(s):  
Matthew B Yurgelun ◽  
Ajay Goel ◽  
C Richard Boland ◽  
Elena M Stoffel ◽  
Keyword(s):  
Lynch Syndrome ◽  
Microsatellite Instability ◽  
Colorectal Adenomas ◽  
Hyperplastic Polyps

Colorectal Adenomas in Young Patients: Microsatellite Instability is not a Useful Marker to Detect New Cases of Lynch Syndrome

2008 ◽  
Vol 51 (6) ◽  
pp. 909-915 ◽  
Author(s):  
Sara Ferreira ◽  
Isabel Claro ◽  
Pedro Lage ◽  
Bruno Filipe ◽  
Ricardo Fonseca ◽  
...  
Keyword(s):  
Lynch Syndrome ◽  
Microsatellite Instability ◽  
Young Patients ◽  
Colorectal Adenomas

scholarly journals Microsatellite Instability is Associated with the Macroscopic Configuration of Neoplasms in Patients with Multiple Colorectal Adenomas

1998 ◽  
Vol 28 (7) ◽  
pp. 427-430 ◽  
Author(s):  
S. Sasaki ◽  
T. Masaki ◽  
N. Umetani ◽  
M. Shinozaki ◽  
T. Yokoyama ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Colorectal Adenomas

M1934 High Sensitivity of Microsatellite Instability (MSI) and Immunohistochemistry (IHC) Testing in Benign Colorectal Adenomas from Patients with Lynch Syndrome

2009 ◽  
Vol 136 (5) ◽  
pp. A-450
Author(s):  
Maria S. Pino ◽  
Mari Mino-Kenudson ◽  
Bernadette M. Wildemore ◽  
Aniruddha Ganguly ◽  
Julie M. Batten ◽  
...  
Keyword(s):  
Lynch Syndrome ◽  
Microsatellite Instability ◽  
High Sensitivity ◽  
Colorectal Adenomas

Microsatellite instability in colorectal adenomas

1997 ◽  
Vol 112 (5) ◽  
pp. 1515-1519 ◽  
Author(s):  
WS Samowitz ◽  
ML Slattery
Keyword(s):  
Microsatellite Instability ◽  
Colorectal Adenomas

scholarly journals Microsatellite instability screening in colorectal adenomas to detect Lynch syndrome patients? A systematic review and meta-analysis

2019 ◽  
Vol 28 (3) ◽  
pp. 277-286 ◽  
Author(s):  
Parag D. Dabir ◽  
Carlijn E. Bruggeling ◽  
Rachel S. van der Post ◽  
Bas E. Dutilh ◽  
Nicoline Hoogerbrugge ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lynch Syndrome ◽  
Microsatellite Instability ◽  
Meta Analysis ◽  
Colorectal Adenomas

Research Consumerism 101: Evaluating External Evidence of Treatment Effectiveness

2008 ◽  
Vol 17 (2) ◽  
pp. 43-49
Author(s):  
James L. Coyle
Keyword(s):  
Treatment Effectiveness ◽  
Code Of Ethics ◽  
Oropharyngeal Dysphagia ◽  
Clinical Importance ◽  
Professional Services ◽  
Adverse Outcomes ◽  
Professional Judgment ◽  
Evidence Based ◽  
Intervention Selection ◽  
Published Research

Abstract The modern clinician is a research consumer. Rehabilitation of oropharyngeal impairments, and prevention of the adverse outcomes of dysphagia, requires the clinician to select interventions for which evidence of a reasonable likelihood of a successful, important outcome exists. The purpose of this paper is to provide strategies for evaluation of published research regarding treatment of oropharyngeal dysphagia. This article utilizes tutorial and examples to inform and educate practitioners in methods of appraising published research. It provides and encourages the use of methods of efficiently evaluating the validity and clinical importance of published research. Additionally, it discusses the importance of the ethical obligation we, as practitioners, have to use evidence-based treatment selection methods and measurement of patient performance during therapy. The reader is provided with tactics for evaluating treatment studies to establish a study's validity and, thereby, objectively select interventions. The importance of avoiding subjective or unsubstantiated claims and using objective methods of generating empirical clinical evidence is emphasized. The ability to evaluate the quality of research provides clinicians with objective intervention selection as an important, essential component of evidence-based clinical practice. ASHA Code of Ethics (2003): Principle I, Rule F: “Individuals shall fully inform the persons they serve of the nature and possible effects of services rendered and products dispensed…” (p. 2) Principle I, Rule G: “Individuals shall evaluate the effectiveness of services rendered and of products dispensed and shall provide services or dispense products only when benefit can reasonably be expected.” (p. 2) Principle IV, Rule G: “Individuals shall not provide professional services without exercising independent professional judgment, regardless of referral source or prescription.” (p. 4)

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