Cyclin E overexpression as an independent risk factor of visceral relapse in breast cancer

2001 ◽  
Vol 27 (5) ◽  
pp. 464-471 ◽  
Author(s):  
Hark K. Kim ◽  
In-A. Park ◽  
Dae S. Heo ◽  
Dong-Y. Noh ◽  
Kuk-J. Choe ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Cyclin E

Metabolic syndrome is an independent risk factor for breast cancer

2011 ◽  
Vol 284 (5) ◽  
pp. 1271-1276 ◽  
Author(s):  
Lakymê Ângelo Mangueira Porto ◽  
Karla Jamille Bezerra Lora ◽  
Juliana Coutinho Miranda Soares ◽  
Laura Olinda Bregieiro Fernandes Costa
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Risk Factor ◽  
Independent Risk Factor

Tenascin-C promotes bladder cancer progression, depends on syndecan-4 and involves NF-κB signaling activation

2021 ◽  
Author(s):  
zhenfeng guan ◽  
yi sun ◽  
liang mu ◽  
yazhuo jiang ◽  
Jinhai fan
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Bladder Cancer ◽  
Risk Factor ◽  
Cancer Progression ◽  
Independent Risk Factor ◽  
Tumor Grade ◽  
Tenascin C ◽  
Tract Disease ◽  
Signaling Activation

Abstract Bladder cancer (BCa) is an unfortunately critical genitourinary tract disease with an uncertain pathology. Increasing evidence indicates that the tumor microenvironment is decisive with respect to cancer progression, and that this is driven by tumor cell interactions with stromal components. Tenascin-C (TN-C) is an important extracellular matrix (ECM) component and TN-C has been reported to be involved in other cancers, i.e. breast cancer. Expression of TN-C in BCa tissue is reported to positively correlate to BCa pathologic grade, yet the presence of urine TN-C is regarded as an independent risk factor for BCa. Thus, we assessed the value of TN-C in BCa tissues and noted that it also was increased according to tumor grade and was an independent risk factor for BCa. In fact, TN-C contributes to BCa cell migration, invasion and proliferation and this is dependent on syndecan-4 and involves NF-κB signaling activation. How syndecan-4 is linked to activation of NF-κB signaling is unclear. Our data provide a foundation for future investigations into TN-C’s contribution to BCa progression.

Obesity as an independent risk factor for decreased survival in node-positive high-risk breast cancer

2015 ◽  
Vol 151 (3) ◽  
pp. 569-576 ◽  
Author(s):  
Christoph Scholz ◽  
U. Andergassen ◽  
P. Hepp ◽  
C. Schindlbeck ◽  
Thomas W. P. Friedl ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
High Risk ◽  
Independent Risk Factor ◽  
Node Positive ◽  
High Risk Breast Cancer ◽  
High Risk Breast ◽  
Risk Breast Cancer

A novel and automatic mammographic texture resemblance marker is an independent risk factor for breast cancer

2011 ◽  
Vol 35 (4) ◽  
pp. 381-387 ◽  
Author(s):  
M. Nielsen ◽  
G. Karemore ◽  
M. Loog ◽  
J. Raundahl ◽  
N. Karssemeijer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Independent Risk Factor

scholarly journals Is Collagen an Independent Risk Factor for Breast Cancer?

2016 ◽  
Author(s):  
Paola Taroni ◽  
Anna Maria Paganoni ◽  
Francesca Ieva ◽  
Francesca Abbate ◽  
Enrico Cassano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Independent Risk Factor

scholarly journals Liver Transplant Recipients Incur More Costly Care When Undergoing Treatment for Breast Cancer

2021 ◽  
Author(s):  
Gregory Veillette ◽  
Maria Castaldi ◽  
Sacha A Roberts ◽  
Afshin Parsikia ◽  
Ankur Choubey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multivariate Analysis ◽  
Risk Factor ◽  
Liver Transplant ◽  
Independent Risk Factor ◽  
Cancer Surgery ◽  
Breast Cancer Surgery ◽  
Transplant Recipients ◽  
Operative Complications ◽  
Liver Transplant Recipients

Abstract Purpose The incidence of breast cancer (BC) in solid organ transplant recipients is comparable to the age-matched general population. It is among the three top-most commonly occurring cancers in women after liver transplantation (LT). There is limited information on the management and outcomes of breast cancer in liver transplant recipients (LTR). We aim to evaluate the impact of LT on breast cancer surgery outcomes. Further we compare the outcomes after breast cancer surgery in LTR in transplant versus non-transplant centers. Methods National Inpatient Sample (NIS) database was accessed to identify LTR with BC. Mortality, complications, hospital charges and total length of stay (LOS) were evaluated with multivariate logistic regression testing. Weighted multivariate regression models were employed to compare outcomes at transplant and non-transplant centers. Results Ninety-nine women met inclusion criteria for LT + BC and were compared against a cohort of women with BC without LT (n = 736,527). LT + BC had lower performance status as confirmed via higher Elixhauser Comorbidity Index (20.5% vs.10.2%, p < 0001). There were significantly more complications in the LT cohort when compared to the non-LTR (15.0% vs. 8.2%, p = 0.012). However, on multivariate analysis, LT was not an independent risk factor for post-operative complications following breast cancer surgery (OR 1.223, p = 0.480). Cost associated with breast cancer care was significantly higher in those with LT (2.621, p < 0.001). Breast conservation surgery in LT had shorter LOS as compared to BC alone (OR 0.568, p 0.027) in all hospitals. Conclusion LT does not increase short-term mortality when undergoing breast cancer surgery. Although there were significantly more complications in the LT cohort when compared to the non-LTR (15.0% vs. 8.2%, p = 0.012), on multivariate analysis, LT was not an independent risk factor for post-operative complications following breast cancer surgery. Additionally, breast cancer treatment is more costly in LTR.

scholarly journals Efficacy analysis of intraoperative radiotherapy in patients with early-stage breast cancer

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Lin Wang ◽  
Minmin Zhu ◽  
Yuelong Cui ◽  
Xudong Zhang ◽  
Guowen Li
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Clinical Efficacy ◽  
Independent Risk Factor ◽  
Early Stage ◽  
Intraoperative Radiotherapy ◽  
Disease Free Survival ◽  
Early Stage Breast Cancer ◽  
Rank Test ◽  
Wound Complications

Abstract Background To analyze the clinical efficacy of intraoperative radiotherapy (IORT) after breast-conserving surgery (BCS) in patients with early-stage breast cancer (BC), and to investigate the relationship between its influencing factors and clinical efficacy and prognosis. Methods A total of 73 patients with early-stage BC who underwent IORT after BCS in our hospital were selected in this research. Results Kaplan-Meier survival analysis was used to analyze the related factors of BCS and IORT of disease-free survival (DFS) and overall survival (OS). It was found that only age (χ2 = 14.035, P = 0.003) was statistically positively correlated with the patient’s DFS, and local recurrence and metastasis rate and mortality were higher in patients over 70 years old. Log rank test was used to analyze multiple factors. Only the diameter of the applicator (χ2 = 70.378, P < 0.05) was statistically significant with wound complications, and the larger the diameter, the higher incidence of wound complications. The remaining risk factors did not increase the incidence of wound complications. COX multivariate analysis showed that age was an independent risk factor for DFS rate and the risk factor had no significant effect on the OS rate of patients undergoing IORT after BCS. Conclusions IORT may be a safe form of treatment for the selected patients with early-stage BC, and can achieve satisfactory esthetic effect. Larger applicator diameters may increase the incidence of wound complications. Age is an independent risk factor for DFS in early-stage BC patients undergoing IORT after BCS.

Sign in / Sign up

Export Citation Format

Share Document