scholarly journals Validation of Modified Breast Graded Prognostic Assessment for breast cancer patients with brain metastases: extra-cranial disease progression is an independent risk factor

2019 ◽  
Vol 8 (4) ◽  
pp. 390-400 ◽  
Author(s):  
Qingyuan Zhuang ◽  
Ru Xin Wong ◽  
Wei Xiang Lian ◽  
You Quan Li ◽  
Fuh Yong Wong
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Brain Metastases ◽  
Disease Progression ◽  
Cancer Patients ◽  
Independent Risk Factor ◽  
Breast Cancer Patients ◽  
Prognostic Assessment ◽  
Graded Prognostic Assessment

Graded prognostic assessment (GPA) of HER2 positive breast cancer patients with brain metastases.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 589-589
Author(s):  
Ming Chi ◽  
Vyshak Alva Venur ◽  
Alireza Mohammad Mohammadi ◽  
Samuel T. Chao ◽  
G. Thomas Budd ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Her2 Positive ◽  
Her2 Positive Breast Cancer ◽  
Prognostic Assessment ◽  
Graded Prognostic Assessment ◽  
Positive Breast Cancer

The breast graded prognostic assessment is associated with the survival outcomes in breast cancer patients receiving whole brain re-irradiation

2018 ◽  
Vol 138 (3) ◽  
pp. 637-647 ◽  
Author(s):  
Shih-Fan Lai ◽  
Yu-Hsuan Chen ◽  
Tony Hsiang-Kuang Liang ◽  
Che-Yu Hsu ◽  
Huang-Chun Lien ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Survival Outcomes ◽  
Breast Cancer Patients ◽  
Whole Brain ◽  
Prognostic Assessment ◽  
Graded Prognostic Assessment

Meningism as a poor risk factor in breast cancer patients with relapse in central nervous system (CNS).

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e11518-e11518
Author(s):  
Luis Jesus Schwarz ◽  
Carlos S. Vallejos ◽  
Silvia P. Neciosup ◽  
Joseph Pinto ◽  
Tatiana Vidaurre ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Brain Metastases ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Cox Regression ◽  
Categorical Variables ◽  
Breast Cancer Patients ◽  
Cns Relapse ◽  
Her 2

e11518 Background: CNS relapse in breast cancer patients is invariably defined as a poor prognosis feature with varied and bizarre clinical presentation. We describe the commonest signs and symptoms in CNS relapse and their relation with prognosis Methods: We evaluate retrospectively 2597 women with breast cancer treated at the Instituto Nacional de Enfermedades Neoplásicas (Lima-Perú) between 2000-2005. Phenotypes were determined by IHC and categorized in [HR+, HER2-], triple-negative (TN) [HR-, HER2-] and Her-2 [HR+/-, HER2 +]. Post-CNS recurrence survival was calculated by Kaplan Meier method. We use Chi-square, or exact Fisher test when appropriate, to evaluate correlations between categorical variables. Results: 157 pts (6.04%) had CNS relapse from which 19 had only leptomeningeal carcinomatosis (LMC), 124 only brain metastases and 14 both. In regard to phenotype, 43pts were [HR+, HER2-] (5 LMC), 68 were TN (13 LMC) and 51 were [HR+/-, HER2 +] (15 LMC). 152 pts had stages I-III (96.8% of all SNC relapses). There was no association between phenotypes and age at CNS relapse, ECOG PS, extracraneal metastases, control of primary tumor, number or volume of brain metastases. Significant association was found between phenotype and time from diagnosis to CNS relapse (≤8 months: 16.3% in TN, 7.3% in Her-2 and 0% for [HR+, HER2-], [P=0.017] ) and histological grade (grade III: 74.4% in TN, 55.% in Her-2 and 30% for [HR+, HER2-], [P=0.006]). Symptoms/signs frequently described in LMC patients were cephalea (72%), meningism (24%), nausea (24%), vomiting (20%), ataxia (20%), facial palsy (16%), somnolence (16%), paraparesia (12%), hiporeflexia (12%), apraxia (12%), arreflexia (12%), poor sphincter control (12%), hemiparesia (8%), seizures (8%), bradipsiquia (8%), neuropathic pain (4%). Fifty percent of TN pts with LMC had meningism. Post recurrence survival was shorter in TN patients (3.61mo vs 4.89mo to [HR+, HER2-] vs 5.95mo to [HR+/-, HER2 +; P=0.044] and in patients with meningism (1.38mo vs 5.26mo; P=0.02). Cox regression identify meningism as a risk factor for survival in patients relapsed with LMC (HR: 4.33; P=0.066). Conclusions: Meningism seems to be the only sign related to poor prognosis in patients relapsed with LMC.

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