scholarly journals Induced abortion as an independent risk factor for breast cancer: a comprehensive review and meta-analysis.

1996 ◽  
Vol 50 (5) ◽  
pp. 481-496 ◽  
Author(s):  
J Brind ◽  
V M Chinchilli ◽  
W B Severs ◽  
J Summy-Long
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Meta Analysis ◽  
Induced Abortion ◽  
Comprehensive Review

scholarly journals Cytoplasmic HAX1 Is an Independent Risk Factor for Breast Cancer Metastasis

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Alicja Trebinska-Stryjewska ◽  
Lukasz Szafron ◽  
Alina Rembiszewska ◽  
Maciej Wakula ◽  
Sylwia Tabor ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Cancer Metastasis ◽  
Meta Analysis ◽  
Distant Metastases ◽  
Copy Number Gain ◽  
Breast Cancer Metastasis ◽  
Primary Tumors ◽  
Metastatic Relapse

HAX1 is an antiapoptotic factor involved in the regulation of cell migration and calcium homeostasis, overexpressed in several cancers, including breast cancer. It has been suggested that HAX1 is also implicated in metastasis. Herein we report the results of meta-analysis of HAX1 expression, based on publicly available data, which confirms its significant overexpression in breast cancer and demonstrates copy number gain and prognostic value of HAX1 overexpression for metastatic relapse in ER+ tumors. IHC analysis reported here also reveals its significant overexpression in breast cancer samples from primary tumors, indicating significantly higher HAX1 protein levels in a group of patients who developed distant metastases in a disease course. Moreover, we demonstrate that HAX1 localization is important for the prediction of metastatic relapse and that cytoplasmic but not nuclear HAX1 is an independent risk factor for breast cancer metastasis.

scholarly journals Induced abortion as an independent risk factor for breast cancer.

1997 ◽  
Vol 51 (4) ◽  
pp. 465-467 ◽  
Author(s):  
M Blettner ◽  
J Chang-Claude ◽  
T Scheuchenpflug
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Induced Abortion

scholarly journals Sleep apnoea is a risk factor for severe COVID-19

2021 ◽  
Vol 8 (1) ◽  
pp. e000845
Author(s):  
Satu Strausz ◽  
Tuomo Kiiskinen ◽  
Martin Broberg ◽  
Sanni Ruotsalainen ◽  
Jukka Koskela ◽  
...  
Keyword(s):  
Risk Factor ◽  
Independent Risk Factor ◽  
Causes Of Death ◽  
Meta Analysis ◽  
Sleep Apnoea ◽  
Male Gender ◽  
Multivariate Logistic Regression Model ◽  
Multivariate Logistic Regression ◽  
Obstructive Sleep ◽  
Positive Controls

BackgroundObstructive sleep apnoea (OSA) is associated with higher body mass index (BMI), diabetes, older age and male gender, which are all risk factors for severe COVID-19.We aimed to study if OSA is an independent risk factor for COVID-19 infection or for severe COVID-19.MethodsOSA diagnosis and COVID-19 infection were extracted from the hospital discharge, causes of death and infectious diseases registries in individuals who participated in the FinnGen study (n=260 405). Severe COVID-19 was defined as COVID-19 requiring hospitalisation. Multivariate logistic regression model was used to examine association. Comorbidities for either COVID-19 or OSA were selected as covariates. We performed a meta-analysis with previous studies.ResultsWe identified 445 individuals with COVID-19, and 38 (8.5%) of them with OSA of whom 19 out of 91 (20.9%) were hospitalised. OSA associated with COVID-19 hospitalisation independent from age, sex, BMI and comorbidities (p-unadjusted=5.13×10−5, OR-adjusted=2.93 (95% CI 1.02 to 8.39), p-adjusted=0.045). OSA was not associated with the risk of contracting COVID-19 (p=0.25). A meta-analysis of OSA and severe COVID-19 showed association across 15 835 COVID-19 positive controls, and n=1294 patients with OSA with severe COVID-19 (OR=2.37 (95% 1.14 to 4.95), p=0.021).ConclusionRisk for contracting COVID-19 was the same for patients with OSA and those without OSA. In contrast, among COVID-19 positive patients, OSA was associated with higher risk for hospitalisation. Our findings are in line with earlier works and suggest OSA as an independent risk factor for severe COVID-19.

Metabolic syndrome is an independent risk factor for breast cancer

2011 ◽  
Vol 284 (5) ◽  
pp. 1271-1276 ◽  
Author(s):  
Lakymê Ângelo Mangueira Porto ◽  
Karla Jamille Bezerra Lora ◽  
Juliana Coutinho Miranda Soares ◽  
Laura Olinda Bregieiro Fernandes Costa
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Risk Factor ◽  
Independent Risk Factor

Abstract B05: GSTM1 as risk factor for breast cancer: Meta-analysis of 57 studies

2013 ◽  
Author(s):  
Mildred C. Gonzales ◽  
Pamela Shiao ◽  
Amanda Lie ◽  
Ching-Yi Chiu ◽  
Maria Suarez
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Meta Analysis

Is gestational diabetes mellitus an independent risk factor for macrosomia: a meta-analysis?

2014 ◽  
Vol 291 (4) ◽  
pp. 729-735 ◽  
Author(s):  
Xiu-Jie He ◽  
Feng-yun Qin ◽  
Chuan-Lai Hu ◽  
Meng Zhu ◽  
Chao-Qing Tian ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Independent Risk Factor ◽  
Meta Analysis

Birth Weight as a Risk Factor for Breast Cancer: A Meta-Analysis of 18 Epidemiological Studies

2009 ◽  
Vol 18 (8) ◽  
pp. 1169-1178 ◽  
Author(s):  
Xiaohui Xu ◽  
Amy B. Dailey ◽  
Mary Peoples-Sheps ◽  
Evelyn O. Talbott ◽  
Ning Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Birth Weight ◽  
Meta Analysis ◽  
Epidemiological Studies

Cyclin E overexpression as an independent risk factor of visceral relapse in breast cancer

2001 ◽  
Vol 27 (5) ◽  
pp. 464-471 ◽  
Author(s):  
Hark K. Kim ◽  
In-A. Park ◽  
Dae S. Heo ◽  
Dong-Y. Noh ◽  
Kuk-J. Choe ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Cyclin E
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