Prognostic significance of peri-operative blood transfusion following radical resection for oesophageal carcinoma

2000 ◽  
Vol 26 (5) ◽  
pp. 492-497 ◽  
Author(s):  
SM Dresner ◽  
PJ Lamb ◽  
J Shenfine ◽  
N Hayes ◽  
SM Griffin
Keyword(s):  
Blood Transfusion ◽  
Prognostic Significance ◽  
Radical Resection ◽  
Oesophageal Carcinoma

Expression of p53 protein in oesophageal carcinoma: Clinicopathological correlation and prognostic significance

1994 ◽  
Vol 81 (11) ◽  
pp. 1623-1626 ◽  
Author(s):  
R. Vijeyasingam ◽  
S. J. Darnton ◽  
K. Jenner ◽  
C. A. Allen ◽  
C. Billingham ◽  
...  
Keyword(s):  
P53 Protein ◽  
Prognostic Significance ◽  
Oesophageal Carcinoma ◽  
Clinicopathological Correlation

scholarly journals Prognostic Significance of Preoperative Blood Transfusion in Stomach Cancer

2010 ◽  
Vol 10 (4) ◽  
pp. 196 ◽  
Author(s):  
Seok Hwan Kim ◽  
Sang-Il Lee ◽  
Seung-Moo Noh
Keyword(s):  
Blood Transfusion ◽  
Stomach Cancer ◽  
Prognostic Significance

Functional Long-Term Outcome of a Free Jejunal Transplant Reconstruction following Chemoradiotherapy and Radical Resection for Hypopharyngeal and Proximal Oesophageal Carcinoma

2004 ◽  
Vol 21 (5-6) ◽  
pp. 426-433 ◽  
Author(s):  
Henrik Bergquist ◽  
Hasse Ejnell ◽  
Ingemar Fogdestam ◽  
Hans Mark ◽  
Claes Mercke ◽  
...  
Keyword(s):  
Radical Resection ◽  
Oesophageal Carcinoma ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Effect of Intraoperative Blood Transfusion On Treg And Foxp3 In Patients With Digestive Tract Malignancies And Different Abo Blood Types

2020 ◽  
Author(s):  
Yajun Liu ◽  
Junzhi Sun ◽  
Yun Xia ◽  
Michael R. Lyaker ◽  
Jianshe Yu
Keyword(s):  
Blood Transfusion ◽  
Digestive Tract ◽  
Blood Group ◽  
Radical Resection ◽  
Foxp3 Expression ◽  
Blood Type ◽  
Foxp3 Mrna ◽  
Blood Types ◽  
Significant Difference ◽  
Group A

Abstract Background Blood transfusion can cause immunosuppression and lead to worse outcomes in patients with digestive tract malignancies; however, the specific mechanism behind this is not completely understood. One theory is that increased numbers of regulatory CD3 + CD4 + CD25 + FOXP3 + T cells (Tregs) and forkhead box protein-3 mRNA (FOXP3) expression in the blood after transfusion contribute to these outcomes. The effect of blood transfusion on immune function in patients with different ABO blood types is variable. This study investigates the effect of intraoperative blood transfusion on the number of Tregs and the expression of FOXP3 in the blood of patients with different ABO blood types and digestive tract malignancies. Methods Patients with digestive tract malignancies who underwent radical resection and received intraoperative blood transfusion were divided into four groups according to their blood types:blood group A, B, O and AB (n=20 ). Blood was collected before surgery, immediately after transfusion, 1 day after transfusion, and 5 days after transfusion. The number of Tregs was measured by flow cytometry. The expression of FOXP3 was detected by real time reverse transcription polymerase chain reaction (RT-PCR). Results There was no significant difference in the number of Tregs or expression of FOXP3 mRNA among patients with different blood types before surgery. However, the number of Tregs and the expression of FOXP3 increased after blood transfusion in all blood type groups. This increase was especially evident and statistically significant on the first day after blood transfusion when compared with measures obtained before the surgery. Measures returned to the preoperative level five days after surgery. There were significant differences in the increase of Tregs and expression of FOXP3 among patients with different blood types. The greatest increase was seen in patients with blood group B and the least in blood group A. Conclusions Intraoperative blood transfusion can lead to an increase in blood Tregs and FOXP3 expression in patients with digestive tract malignancies. Increases were greatest on the first day after surgery and differed among patients with different blood types. Increases were greatest in blood type B and least in blood type A.

scholarly journals Prognostic Factors Affecting Survival of Patients after Liver Resection Due to Colorectal Liver Metastases

2016 ◽  
Vol 70 (3) ◽  
pp. 133-139
Author(s):  
Stefan Petrovski ◽  
Elena Arabadzhieva ◽  
Saso Bonev ◽  
Dimitar Bulanov ◽  
Valentin Popov ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Liver Resection ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Prognostic Significance ◽  
Radical Resection ◽  
University Hospital ◽  
Tumor Type ◽  
Term Survival ◽  
Localization Of Metastases

Abstract Introduction. Colorectal liver metastases have a poor prognosis and only 2% have an average 5-year survival if left untreated. In recent decades there has been a development in the diagnosis, treatment and palliative treatment of patients with colorectal liver metastases, and despite radical resection the average five-year survival is between 25% and 44%. Aim. To explore the experience of the Clinic in the treatment of colorectal liver metastases, comparing it with data from the literature and based on the comparison to determine the prognostic factors that affect survival after radical surgical treatment of patients. Methods. A retrospective study was conducted at the Clinic of General and Hepato-pancreatic Surgery at the University Hospital “Aleksandrovska”-Sofia. The study comprised the period between 01.01.2006 to 31.12.2015. It included a total of 239 cases, of whom: 179 patients underwent radical interventions, 5 palliative and 55 patients underwent explorative interventions due to liver metastases. Clinical and pathological materials were analyzed using SPSS-19 to determine the prognostic significance of a number of factors in relation to the survival: gender, age, type and localization of metastases, postoperative stage of the primary tumor, type and volume of liver resection, extrahepatic metastases, preoperative values of CEA, postoperative values (AST, ALT). Results. Factors that correlated with lower survival type: metastases (synchronous or metachronus), localization of metastases (uni-or bilobar), presence of the regional lymph node metastases and metastases to other distant organs and the impossibility of radical resection of liver were statistically significant with multivariant analysis. Elevated preoperative value of CEA, the value of hemoglobin and stage IV disease also affected the survival of patients. Conclusion. In patients with colorectal liver metastases only resection has potentially curative character. The surgical strategy for resection in context of increasing the percentage of patients with resectable potential is the only possible factor for long-term survival.

scholarly journals A Prospective and Nutrition-Related Nomogram Model for Prognosis in Colorectal Cancer Survival: A Multicenter Cohort Study in China

2020 ◽  
Author(s):  
Guo-Tian Ruan ◽  
Kang-Ping Zhang ◽  
Qi Zhang ◽  
Xi Zhang ◽  
Meng Tang ◽  
...  
Keyword(s):  
Cancer Survival ◽  
Validation Cohort ◽  
External Validation ◽  
Prognostic Significance ◽  
Radical Resection ◽  
Prognostic Indicator ◽  
Prognostic Models ◽  
Prognostic Indicators ◽  
Severe Malnutrition ◽  
Multicenter Cohort Study

Abstract BackgroundColorectal cancer (CRC) is a common malignancy with high incidence of malnutrition. Increasing evidence showed that nutritional status could be a prognostic indicator of cancer survival. However, there were few prognostic models involving nutrition-related indicators in CRC. This study aimed to develop a nutrition-related prognostic model for CRC survival.MethodsThis multicenter retrospectively primary cohort data included 1,373 CRC patients, and the external validation cohort enrolled other 108 CRC patients. LASSO and multivariate regression analyses were used to select prognostic indicators and develop the nomogram. We performed C-index, calibration curves, and DCA to assess the discrimination, calibration, and applicability. Finally, the indicators of the nomogram model were used as adjustment factors. Multivariate Cox survival analyses were performed to investigate the benefit of the Patient-Generated Subjective Global Assessment (PG-SGA) and Global Leadership Initiative on Malnutrition (GLIM) malnutrition criteria to CRC prognosis.ResultsFive prognostic indicators (TNM stage, radical resection, reduced food intake, activities and function decline, and low albumin) were chosen to develop the nomogram. C-index of the nomogram was 0.74 (95% CI 0.72-0.77) and 0.72 (95% CI 0.62-0.81) in the primary cohort and validation cohort, which were higher than other models. Calibration plots and DCA showed that the nomogram model has a good consistency and clinical benefit in predicting CRC survival. Multivariate Cox survival analysis suggested moderate (P<0.05, HR 1.32, 95% CI 1.002-1.75) and severe malnutrition (P<0.001, HR 1.69, 95% CI 1.27-2.25) were associated with worse overall survival (OS) in CRC using the PG-SGA criteria. However, there was no prognostic significance in GLIM criteria (all P>0.05). Finally, stratified analysis suggested that malnourished CRC patients with low albumin synergistically increased the death risk of CRC OS both in PG-SGA and GLIM. (P for interaction = 0.007 and 0.004, respectively)ConclusionThis study established a prospective model to predict the OS in CRC patients using nutrition-related indicators. Moreover, we also found that PG-SGA had a better prognostic and predictive efficiency in CRC than GLIM. These findings grant further verification.

Prognostic significance of the lymphocyte‐to‐monocyte ratio and the tumor‐infiltrating lymphocyte to tumor‐associated macrophage ratio in patients with stage T3N0M0 esophageal squamous cell carcinoma.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15602-e15602
Author(s):  
Yingming Zhu ◽  
Jinming Yu ◽  
Minghuan Li
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neoadjuvant Therapy ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Radical Resection ◽  
Entire Cohort ◽  
Lymphocyte To Monocyte Ratio

e15602 Background: We assessed the prognostic signi cance of, and the relationship between, the pretreatment lymphocyte- to-monocyte ratio (LMR) and the TILs/tumor-associated macrophages (TAMs) ratio, in patients with esophageal squamous cell carcinoma (ESCC) of pathological stage T3N0M0 (pT3N0M0). Methods: A total of 220 newly diagnosed ESCC patients of stage pT3N0M0 who had not undergone neoadjuvant therapy were included. Densities of CD8+ TILs, CD4+ TILs, CD45RO+ TILs, and CD68+ TAMs were assessed by immunohistochemical staining of tissue microarray cores from all 220 pT3N0M0 ESCC patients (who underwent radical resection). Hematological biomarkers including lymphocyte and monocyte counts were obtained from routine preoperative blood test data, and the LMR and TILs/ TAMs ratios calculated. Cutoff nder for survival predic- tion was plotted to nd out the optimal cutoff point for each parameter. Results: The LMR and TILs/TAMs ratios were interrelated. On univariate analyses of data from the entire cohort, the LMR, CD45RO/CD68 ratio, and CD8/CD68 ratio were significantly associated with both OS and disease-free survival. Only the CD45RO/CD68 ratio was independently prognostic of survival on multivariate analysis. Conclusions: The prognostic significance of the CD45RO/ CD68 ratio was higher than that of the LMR. The CD45RO/ CD68 ratio is a useful independent prognostic marker in patients with pT3N0M0 ESCC who have undergone complete resection without neoadjuvant therapy.

scholarly journals Preoperative Plasma D-Dimer Independently Predicts Survival in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Radical Resection

2021 ◽  
Author(s):  
Haoda Chen ◽  
Fanlu Li ◽  
Siyi Zou ◽  
Junjie Xie ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Radical Surgery ◽  
Prognostic Significance ◽  
Radical Resection ◽  
Prognostic Indicator ◽  
Ductal Adenocarcinoma ◽  
R0 Resection ◽  
Clinicopathologic Characteristics ◽  
D Dimer

Abstract Background: Elevated plasma D-dimer levels have been reported as an unfavorable prognostic indicator in many solid tumors. However, there are limited relevant studies in pancreatic cancer patients following radical surgery, and the clinical significance remains controversial. The aim of this study was to investigate the clinical and prognostic significance of preoperative plasma D-dimer in patients with pancreatic ductal adenocarcinoma (PDAC) undergoing resection.Methods: A retrospective analysis was performed of all patients who consecutively underwent radical surgery for PDAC by laparotomy or robotic surgery from December 2011 to December 2018. Baseline clinicopathologic characteristics, preoperative laboratory parameters and follow-up information were collected. Univariate and multivariate analyses were performed to analyze the prognostic value of preoperative plasma D-dimer.Results: Among 1351 patients, elevated preoperative plasma D-dimer levels (≥ 0.55 ng/mL) were found in 417 (30.9%) patients. 312 (23.09%) underwent minimally invasive robotic pancreatectomy. The median overall survival (OS) of patients with elevated D-dimer levels was 6.3 months shorter than that of patients with normal D-dimer levels (15.0 months vs 21.3 months, p < 0.001). Multivariate analysis showed that elevated D-dimer levels independently predicted poorer OS (hazard ratio: 1.33, 95% confidence interval: 1.17-1.51, p < 0.001). Subgroup analysis demonstrated that D-dimer was a reliable prognostic factor in patients who underwent R0 resection. In addition, integration of D-dimer, carbohydrate antigen 19-9 (CA19-9) and NLR provided a better prognostic model for PDAC patients before operation.Conclusion: An elevated preoperative plasma D-dimer level was a reliable independent prognostic factor for OS in patients with PDAC undergoing resection. Combination of D-dimer, CA19-9 and NLR can enhance the prognostic accuracy before operation.

scholarly journals HMGA1-TRIP13 Axis Promotes Stemness and Epithelial Mesenchymal Transition of Perihilar Cholangiocarcinoma in a Positive Feedback Loop Dependent on C-Myc

2021 ◽  
Author(s):  
Zhipeng Li ◽  
Jialiang Liu ◽  
Tianli Chen ◽  
Rongqi Sun ◽  
Zengli Liu ◽  
...  
Keyword(s):  
Positive Feedback ◽  
Epithelial Mesenchymal Transition ◽  
Prognostic Significance ◽  
Radical Resection ◽  
Perihilar Cholangiocarcinoma ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Dismal Prognosis ◽  
Feedback Pathway

Abstract Background: Cholangiocarcinoma is a highly malignant cancer with very dismal prognosis. Perihilar cholangiocarcinoma(pCCA) accounts for more than 50% of all cholangiocarcinoma and is well-characterized for its low rate of radical resection. Effects of radiotherapy and chemotherapy of pCCA are very limited. Methods: Here we screened potential biomarkers of pCCA with transcriptome sequencing and evaluated the prognostic significance of HMGA1 in a large cohort pCCA consisting of 106 patients. With bioinformatics and in vitro/vivo experiments, we showed that HMGA1 induced tumor cell stemness and epithelial-mesenchymal-transition(EMT), and thus facilitated proliferation, migration and invasion by promoting TRIP13 transcription. Moreover, TRIP13 was also an unfavorable prognostic biomarker of pCCA, and double high expression of HMGA1/TRIP13 could predict prognosis more sensitively. TRIP13 promoted pCCA progression by suppressing FBXW7 transcription and stabilizing c-Myc. c-Myc in turn induced the transcription and expression of both HMGA1 and TRIP13, indicating that HMGA-TRIP13 axis facilitated pCCA stemness and EMT in a positive feedback pathway. Conclusions: HMGA1 and TRIP13 were unfavorable prognostic biomarkers of pCCA. HMGA1 enhanced pCCA proliferation, migration, invasion, stemness and EMT, by inducing TRIP13 expression, suppressing FBXW7 expression and stabilizing c-Myc. Moreover, c-Myc can induce the transcription of HMGA1 and TRIP13, suggesting that HMGA-TRIP13 axis promoted EMT and stemness in a positive feedback pathway dependent on c-Myc.

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