Expression of p53 protein in oesophageal carcinoma: Clinicopathological correlation and prognostic significance

1994 ◽  
Vol 81 (11) ◽  
pp. 1623-1626 ◽  
Author(s):  
R. Vijeyasingam ◽  
S. J. Darnton ◽  
K. Jenner ◽  
C. A. Allen ◽  
C. Billingham ◽  
...  
Keyword(s):  
P53 Protein ◽  
Prognostic Significance ◽  
Oesophageal Carcinoma ◽  
Clinicopathological Correlation

Immunohistochemical Expression of p53 Protein and P-glycoprotein and its Prognostic Significance in Osteosarcoma

1999 ◽  
Vol 34 (5) ◽  
pp. 859
Author(s):  
Sang Hoon Lee ◽  
Yong Bum Park ◽  
Han Soo Kim ◽  
Chong Jai Kim ◽  
Woo Jin Kim ◽  
...  
Keyword(s):  
P53 Protein ◽  
Prognostic Significance ◽  
Immunohistochemical Expression ◽  
P Glycoprotein

p53 protein expression in Barrett's adenocarcinoma: a frequent event with no prognostic significance

1994 ◽  
Vol 24 (5) ◽  
pp. 487-489 ◽  
Author(s):  
J.-F. FLÉJOU ◽  
F. PARAF ◽  
F. POTET ◽  
F. MUZEAU ◽  
F. FÉKÉTÉ ◽  
...  
Keyword(s):  
Protein Expression ◽  
P53 Protein ◽  
Prognostic Significance ◽  
P53 Protein Expression ◽  
Frequent Event ◽  
Barrett’S Adenocarcinoma

scholarly journals p53 mutations in mantle cell lymphoma are associated with variant cytology and predict a poor prognosis

Blood ◽  
1996 ◽  
Vol 87 (10) ◽  
pp. 4302-4310 ◽  
Author(s):  
TC Greiner ◽  
MJ Moynihan ◽  
WC Chan ◽  
DM Lytle ◽  
A Pedersen ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Median Survival ◽  
Poor Prognosis ◽  
Denaturing Gradient Gel Electrophoresis ◽  
Cell Lymphoma ◽  
P53 Protein ◽  
Prognostic Significance ◽  
Missense Mutations ◽  
P53 Mutations ◽  
Mantle Cell

Mutations of the p53 tumor suppressor gene have been described in several subtypes of non-Hodgkin's lymphoma, but the incidence of p53 mutations in mantle cell lymphoma (MCL) is unknown. We hypothesized that cases of MCL with a variant or high-grade cytology would have a higher likelihood of p53 mutations than typical MCL. We were also interested in the prognostic significance of p53 mutations in MCL. Therefore, a series of 53 well-characterized cases of MCL with DNA from 62 tissue samples were analyzed by the polymerase chain reaction with denaturing gradient gel electrophoresis for exons 5–8 of p53. Immunoperoxidase studies with the antibody DO-7 to p53 protein were also performed on frozen sections. We found mutations of the p53 gene in 8 of the 53 cases (15%) of MCL. Missense mutations predominated, and 50% of the mutations occurred at known p53 hotspot codons. Of 21 cases with variant cytology (ie, anaplastic or blastic), 6 (28.6%) had p53 mutations as compared with only 2 of 32 cases (6.3%) with typical MCL cytology (P = .05), and p53 mutations preceded the development of variant cytology in 2 patients. Overexpression of p53 protein was observed in 6 of the 8 cases (75%) with p53 mutations and in none of the 45 wild-type cases. The median survival of the cases with mutant p53 was only 1.3 years (all died), whereas the median survival of cases with germline p53 was 5.1 years (P = .023). These results suggest that mutations of p53 may be one mechanism involved in the development of variant forms of MCL and indicate that p53 mutations in MCL predict a poor prognosis.

The prognostic significance of accumulation of p53 protein in stage III non-small cell lung cancer treated by radiotherapy

1995 ◽  
Vol 36 (3) ◽  
pp. 218-224 ◽  
Author(s):  
J.A. Langendijk ◽  
F.B.J.M. Thunnissen ◽  
R.J.S. Lamers ◽  
J.M.A. de Jong ◽  
G.P.M ten Velde ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
P53 Protein ◽  
Prognostic Significance ◽  
Small Cell ◽  
Stage Iii ◽  
Small Cell Lung

scholarly journals Prognostic significance of cyclin E and p53 protein overexpression in carcinoma of the renal pelvis and ureter

1998 ◽  
Vol 77 (5) ◽  
pp. 783-788 ◽  
Author(s):  
M Furihata ◽  
Y Ohtsuki ◽  
H Sonobe ◽  
T Shuin ◽  
A Yamamoto ◽  
...  
Keyword(s):  
Renal Pelvis ◽  
P53 Protein ◽  
Cyclin E ◽  
Prognostic Significance ◽  
Protein Overexpression

PP-6-11 Prognostic significance of p53 protein accumulation in Male Breast Cancer (MBC)

1996 ◽  
Vol 32 ◽  
pp. 40
Author(s):  
B. Massidda ◽  
M.T. Ionta ◽  
G. Porcu ◽  
P.G. Calò ◽  
P. Dessalvi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
P53 Protein ◽  
Prognostic Significance ◽  
Male Breast ◽  
Protein Accumulation
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