Functional Long-Term Outcome of a Free Jejunal Transplant Reconstruction following Chemoradiotherapy and Radical Resection for Hypopharyngeal and Proximal Oesophageal Carcinoma

2004 ◽  
Vol 21 (5-6) ◽  
pp. 426-433 ◽  
Author(s):  
Henrik Bergquist ◽  
Hasse Ejnell ◽  
Ingemar Fogdestam ◽  
Hans Mark ◽  
Claes Mercke ◽  
...  
Keyword(s):  
Radical Resection ◽  
Oesophageal Carcinoma ◽  
Term Outcome ◽  
Long Term Outcome

Long-term outcomes in children with glioblastoma

2010 ◽  
Vol 6 (2) ◽  
pp. 145-149 ◽  
Author(s):  
Kyung Sun Song ◽  
Ji Hoon Phi ◽  
Byung-Kyu Cho ◽  
Kyu-Chang Wang ◽  
Ji Yeoun Lee ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Progression Free Survival ◽  
Radical Resection ◽  
Tumor Location ◽  
Recurrent Glioblastoma ◽  
Subtotal Resection ◽  
Long Term Outcomes ◽  
Term Outcome ◽  
Long Term Outcome

Object Glioblastoma is the most common primary malignant brain tumor; however, glioblastoma in children is less common than in adults, and little is known about its clinical outcome in children. The authors evaluated the long-term outcome of glioblastoma in children. Methods Twenty-seven children were confirmed to have harbored a glioblastoma between 1985 and 2007. The clinical features and treatment outcomes were reviewed retrospectively. All patients underwent resection; complete resection was performed in 12 patients (44%), subtotal resection in 12 patients (44%), and biopsy in 3 patients (11%). Twenty-four patients (89%) had radiation therapy, and 14 (52%) patients received chemotherapy plus radiation therapy. Among the latter, 5 patients had radiation therapy concurrent with temozolomide chemotherapy. Four patients with small-size recurrent glioblastoma received stereotactic radiosurgery. Results The median overall survival (OS) was 43 months, and the median progression-free survival was 12 months. The OS rate was 67% at 1 year, 52% at 2 years, and 40% at 5 years. The median OS was significantly associated with tumor location (52 months for superficially located tumors vs 7 months for deeply located tumors; p = 0.017) and extent of removal (106 months for completely resected tumors vs 11 months for incompletely resected tumors; p < 0.0001). Conclusions The prognosis of glioblastoma is better in children than in adults. Radical resection followed by concurrent chemoradiation therapy may be the initial treatment of choice.

Surgical treatment of low-grade gliomas in the intraoperative magnetic resonance imager

1998 ◽  
Vol 4 (4) ◽  
pp. E10 ◽  
Author(s):  
Claudia Martin ◽  
Eben Alexander ◽  
Terry Wong ◽  
Richard Schwartz ◽  
Ferenc Jolesz ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Image Guidance ◽  
Intraoperative Imaging ◽  
Radical Resection ◽  
Low Grade ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Low Grade Gliomas ◽  
Surgical Field

Radical resection of low-grade gliomas can decrease the incidence of recurrence, the time to tumor progression, and the incidence of malignant transformation. The authors present a series of 25 patients who underwent craniotomy and resection of low-grade tumor in an intraoperative magnetic resonance (MR) imager. This is an open configuration 0.5-tesla imager developed by The Brigham and Women's Hospital and General Electric, in which a patient can be placed to undergo surgery. Gross-total removal was accomplished under real-time image guidance. These intraoperative images allow definitive localization and targeting of the lesions and accommodate anatomical changes that may occur during surgery. The authors consistently found that the extent of abnormality seen on the intraoperatively obtained films of resection was larger than that apparent in the surgical field of view alone. Intraoperative imaging made accurate surgical identification of these abnormal areas and subsequent resection possible. Patients with tumors adjacent to or within motor or language cortex underwent resection while awake, with monitoring of neurological function. In these cases, an aggressive resection without increased neurological morbidity was accomplished using the image guidance in conjunction with serial testing. A 1-month postoperative MR image was obtained in all patients. These correlated with the final intraoperative images obtained after the resection was completed. Only one patient had a mild postoperative deficit that remained at the 1-month follow-up examination. As the long-term outcome in patients with low-grade gliomas has been shown to correspond to the degree of resection, surgical resection in which intraoperative MR imaging guidance is used can be an invaluable modality in the treatment of these tumors.

scholarly journals Long-term outcome of indwelling colon observed seven years after radical resection for rectosigmoid cancer: A case report

2021 ◽  
Vol 9 (19) ◽  
pp. 5252-5258
Author(s):  
Zi-Xuan Zhuang ◽  
Ming-Tian Wei ◽  
Xu-Yang Yang ◽  
Yang Zhang ◽  
Wen Zhuang ◽  
...  
Keyword(s):  
Case Report ◽  
Radical Resection ◽  
Term Outcome ◽  
Rectosigmoid Cancer ◽  
Long Term Outcome

scholarly journals Presentation and surgical results of incidentally discovered nonfunctioning pituitary adenomas: evidence for a better outcome independently of other patients' characteristics

2013 ◽  
Vol 169 (6) ◽  
pp. 735-742 ◽  
Author(s):  
Marco Losa ◽  
Carmine A Donofrio ◽  
Raffaella Barzaghi ◽  
Pietro Mortini
Keyword(s):  
Multivariate Analysis ◽  
Residual Tumor ◽  
Radical Resection ◽  
Control Group ◽  
Surgical Results ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Asymptomatic Patients ◽  
Few Data

ObjectiveFew data are available on the surgical results in patients with incidentally discovered nonfunctioning pituitary adenoma (NFPA). We investigated the efficacy and safety of surgery in patients with incidentally discovered NFPA.DesignRetrospective analysis of prospectively recorded outcomes.MethodsFrom 1990 to 2011, of 804 consecutive patients undergoing surgery for NFPA, 212 cases had an incidentally discovered tumor (26.4%). Among them, 117 patients were asymptomatic, while 95 had some visual and/or hormonal deficit. The main outcome of the study was to evaluate the frequency of radical resection as judged on the first postoperative neuroimaging study and detection of recurring disease during long-term follow-up.ResultsPostoperative residual tumor was detected in 8.9% of patients with asymptomatic incidentalomas as compared with 31.2% of patients with symptomatic incidentalomas (P<0.001) and 41.2% of patients in the control group (P<0.001). Multivariate analysis confirmed that having an asymptomatic incidentaloma was independently associated with a better outcome. The 5-year recurrence-free survival in patients with incidentaloma was 86.8% (95% CI 80.2–92.4%) as compared with 77.9% (95% CI 73.6–82.2%; P<0.01) in the control group. This difference was almost completely due to a lower frequency of relapse in asymptomatic patients. Multivariate analysis confirmed the independent lower risk of tumor recurrence in asymptomatic NFPA.ConclusionOur study shows for the first time that surgically treated patients with asymptomatic NFPA have a better early and long-term outcome that is independent from all the other demographic, clinical, and morphologic characteristics of the patients.

Trigeminal neurinomas with extracranial extension: analysis of 28 surgically treated cases

2010 ◽  
Vol 113 (5) ◽  
pp. 1079-1084 ◽  
Author(s):  
Atul Goel ◽  
Abhidha Shah ◽  
Dattatraya Muzumdar ◽  
Trimurti Nadkarni ◽  
Aadil Chagla
Keyword(s):  
Posterior Fossa ◽  
Tumor Resection ◽  
Radical Resection ◽  
Middle Fossa ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Additional Surgery ◽  
Lateral Orbitotomy ◽  
Transcranial Approach

Object The object of this paper was to review the authors' experience with 28 cases of trigeminal neurinomas having an extracranial extension. Methods The authors analyzed 28 cases of trigeminal neurinoma in which there was an extracranial extension of the tumor. All patients were treated in their department between the years 1989 and 2009. Results There was tumor extension along the ophthalmic division of the nerve in 4 cases, along the maxillary division in 5, and along the mandibular division in 13. In 6 tumors there was diffuse extracranial extension and the exact extracranial division of nerve involvement could not be ascertained. In 10 cases, the tumor had a multicompartmental location—in the posterior fossa, the middle fossa, and the extracranial compartment. Tingling paraesthesiae, numbness, and diffuse pain in the distribution of the trigeminal nerve were common symptoms and were present in 90% of patients. The extracranial component had a well-defined perineural/meningeal membrane cover that was continuous with the middle fossa dura mater and isolated the tumor tissue from the adjoining critical structures. In 7 out of 10 cases, even the posterior fossa component of the tumor was entirely “interdural” (within the confines of the dura). The maximum dimension of the tumor was > 4 cm in 22 cases. A limited “transcranial” approach with (12 cases) or without (16 cases) zygomatic osteotomy was found suitable for resection of these tumors. In 4 cases a lateral orbitotomy was performed. Total tumor resection was performed in 20 cases and partial resection in 8. The duration of follow-up ranged from 6 months to 19 years. Two patients required additional surgery for symptomatic recurrence. Conclusions Extracranial extensions of trigeminal neurinomas have a well-defined meningeal covering. In most cases resection was performed via a minimally invasive cranial avenue (a “reverse skull base approach”). Radical resection was associated with an excellent long-term outcome.

230 Long Term Outcome of Early Colorectal Cancer Treated With Local Excision or Radical Resection

2010 ◽  
Vol 138 (5) ◽  
pp. S-44 ◽  
Author(s):  
Monique E. van Leerdam ◽  
Thomas C. Smyrk ◽  
Felicity Enders ◽  
Sara Holton ◽  
Petrus C. de Groen
Keyword(s):  
Colorectal Cancer ◽  
Local Excision ◽  
Radical Resection ◽  
Early Colorectal Cancer ◽  
Term Outcome ◽  
Long Term Outcome
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