Low-threshold GaInAsP bridge-contacted planar buried-ridge structure lasers

1989 ◽  
Vol 25 (5) ◽  
pp. 366 ◽  
Author(s):  
W. Thulke ◽  
A. Zach
Keyword(s):  
Ridge Structure ◽  
Low Threshold

Low-threshold GRIN-SCH AlGaInAs 1.55 μm quantum well buried ridge structure lasers grown by molecular beam epitaxy

1990 ◽  
Vol 26 (13) ◽  
pp. 889 ◽  
Author(s):  
C. Kazmierski ◽  
M. Blez ◽  
M. Quillec ◽  
M. Allovon ◽  
B. Sermage
Keyword(s):  
Molecular Beam Epitaxy ◽  
Quantum Well ◽  
Molecular Beam ◽  
Ridge Structure ◽  
Low Threshold

Plasma-hydrogenated low-threshold wide-band 1.3 μm buried ridge structure laser

1989 ◽  
Vol 25 (21) ◽  
pp. 1433 ◽  
Author(s):  
C. Kazmierski ◽  
B. Theys ◽  
B. Rose ◽  
A. Mircea ◽  
A. Jalil ◽  
...  
Keyword(s):  
Wide Band ◽  
Ridge Structure ◽  
Low Threshold ◽  
Structure Laser

Very low threshold operation of 1.52 μm GaInAsP/InP DFB buried ridge structure laser diodes entirely grown by MOCVD

1988 ◽  
Vol 24 (10) ◽  
pp. 609-611 ◽  
Author(s):  
A. Talneau ◽  
D. Rondi ◽  
M. Krakowski ◽  
R. Blondeau
Keyword(s):  
Laser Diodes ◽  
Ridge Structure ◽  
Low Threshold ◽  
Structure Laser

Ultra-low-threshold, high-bandwidth, very-low noise operation of 1.52 mu m GaInAsP/InP DFB buried ridge structure laser diodes entirely grown by MOCVD

1989 ◽  
Vol 25 (6) ◽  
pp. 1346-1352 ◽  
Author(s):  
M. Krakowski ◽  
D. Rondi ◽  
A. Talneau ◽  
Y. Combemale ◽  
G. Chevalier ◽  
...  
Keyword(s):  
Laser Diodes ◽  
Low Noise ◽  
Ridge Structure ◽  
High Bandwidth ◽  
Low Threshold ◽  
Structure Laser

Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors

2003 ◽  
Vol 70 ◽  
pp. 201-212 ◽  
Author(s):  
Hideaki Nagase ◽  
Keith Brew
Keyword(s):  
Three Dimensional ◽  
Therapeutic Interventions ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Structural Basis ◽  
Structural Elements ◽  
Ridge Structure ◽  
Extracellular Matrix Components ◽  
Metalloproteinase Inhibitors ◽  
The Matrix ◽  
A Disintegrin And Metalloproteinase

The tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of the matrix metalloproteinases (MMPs), enzymes that play central roles in the degradation of extracellular matrix components. The balance between MMPs and TIMPs is important in the maintenance of tissues, and its disruption affects tissue homoeostasis. Four related TIMPs (TIMP-1 to TIMP-4) can each form a complex with MMPs in a 1:1 stoichiometry with high affinity, but their inhibitory activities towards different MMPs are not particularly selective. The three-dimensional structures of TIMP-MMP complexes reveal that TIMPs have an extended ridge structure that slots into the active site of MMPs. Mutation of three separate residues in the ridge, at positions 2, 4 and 68 in the amino acid sequence of the N-terminal inhibitory domain of TIMP-1 (N-TIMP-1), separately and in combination has produced N-TIMP-1 variants with higher binding affinity and specificity for individual MMPs. TIMP-3 is unique in that it inhibits not only MMPs, but also several ADAM (a disintegrin and metalloproteinase) and ADAMTS (ADAM with thrombospondin motifs) metalloproteinases. Inhibition of the latter groups of metalloproteinases, as exemplified with ADAMTS-4 (aggrecanase 1), requires additional structural elements in TIMP-3 that have not yet been identified. Knowledge of the structural basis of the inhibitory action of TIMPs will facilitate the design of selective TIMP variants for investigating the biological roles of specific MMPs and for developing therapeutic interventions for MMP-associated diseases.

Low threshold open science

2014 ◽  
Author(s):  
Chris H. J. Hartgerink
Keyword(s):  
Open Science ◽  
Low Threshold

Iberis amara L. desensitizes low-threshold mechano-sensitive afferents of the colon

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
S Mittler ◽  
MH Müller ◽  
MS Kasparek ◽  
O Kelber ◽  
D Weiser ◽  
...  
Keyword(s):  
Iberis Amara ◽  
Low Threshold

Sans Souci and the Pedagogical Experience

2011 ◽  
Vol 4 (1) ◽  
pp. 93-109 ◽  
Author(s):  
Anne Reinertsen
Keyword(s):  
Critical Thinking ◽  
Student Teachers ◽  
Modern Society ◽  
Modern School ◽  
Low Threshold ◽  
Scientific Competence

This is about the pedagogical experience ahead of or beyond any pedagogical activity or action. It is therefore about perfectibility and/or dealing with something both theoretically and existentially. It is about inclusion and dialogue, but in an indirect manner, and school as a low threshold institution: heterogeneity, pluralism and multiculturalism as the primary characteristics of a modern school in a modern society. This makes school an institution important to life and knowledge. The need for a pedagogy created through a strong scientific orientation through practice or as I prefer; realism, urgent: Pedagogy framed by a good, relevant and strong understanding of context. This makes demands on teachers' competence. It demands more than possessing pedagogical scientific competence. A certain extent of double(d) competence and more is demanded both about what happens in science and about what happens in society and openness always through language and critical thinking or philosophy. This is about becoming teacher in/and for the fractured future and about what we might “give” (student) teachers in addition.

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