Perioperative Voice Recovery: A Wound-Healing Perspective

2013 ◽  
Vol 23 (2) ◽  
pp. 42-46 ◽  
Author(s):  
Ryan C. Branski
Keyword(s):  
Wound Healing ◽  
Human Body ◽  
Vocal Fold ◽  
Healing Process ◽  
Surgical Excision ◽  
Vocal Folds ◽  
Favorable Outcome ◽  
Wound Healing Process ◽  
License Plate ◽  
Biochemical Processes

To describe the wound healing process through an oversimplified graphic, a classic cartoon in a Dermatology Clinics textbook shows a Volkswagen Beetle, with the license plate TRAUMA that has driven through a wooden fence, leaving both a substantive hole in the fence and piles of broken wooden planks. The obvious priority would be to rebuild the fence so that it is identical to its pretrauma state. This analogy and accompanying graphic provide a framework for a unique perspective on wound healing. For the sake of simplicity, let us assume that the vocal fold is a fence, and instead of a Volkswagen Beetle, the trauma is surgical excision of a vocal fold lesion. Immediately following surgery, the human body initiates the process of rebuilding vocal fold tissue. From a physiological perspective, it would be ideal to regain the original architecture of the vocal fold to ensure minimal alteration to phonatory physiology. Unfortunately, beyond the 2nd trimester of gestation, wounds heal with subsequent scarring. In the vocal folds, this scarring can have significant deleterious effects on vocal fold pliability and lead to dysphonia. However, investigators have shown that wounds heal regeneratively (i.e., no scarring) in the fetal environment. This observation provides potential targets for therapies to direct wound healing toward a more favorable outcome. In this article, I provide a brief overview of the biochemical processes associated with wound healing. Subsequently, I outline the underlying rationale for tissue mobilization in the context of acute vocal fold injury.

scholarly journals Investigating the Wound Healing Potential of the Polyherbal Gels Prepared with Ficus Extract

2018 ◽  
Vol 8 (2) ◽  
pp. 13-16
Author(s):  
Mahender K ◽  
Ravi D ◽  
Chaitanya Kumar K ◽  
Mothilal K
Keyword(s):  
Wound Healing ◽  
Inflammatory Response ◽  
Human Body ◽  
Healing Process ◽  
The Body ◽  
Wound Healing Process ◽  
Aqueous Extracts ◽  
Standard Drug ◽  
Carbopol Gel ◽  
Ficus Benghalensis

Wounds are nothing but any damage to the tissue or skin that can be healed. The wound healing process is usually built in the human body to self heal many wounds. When there is an injury in the body, there is an inflammatory response that is generated in the body, and the cells begin to raise the collagen levels in the skin which enables to increase the healing process. Ficus species of plants are famous for their potency to treat diseases in various Indian systems of medicine and the tree is commonly called as a banyan. Especially the plant in the species benghalensis is used to treat rheumatism, wounds and other skin related problems like an ulcer. The herbal gels were prepared using the incorporation of the aqueous extracts of the plant Ficus benghalensis into carbopol gel. They were investigated for the wound healing potential compared to the betadine drug standard. The gels at a concentration 200mg/g of the gel showed better activity compared to the gel at 100mg/g and the standard drug, betadine.

scholarly journals Advances in Skin Wound and Scar Repair by Polymer Scaffolds

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6110
Author(s):  
Shuiqing Zhou ◽  
Qiusheng Wang ◽  
Ao Huang ◽  
Hongdou Fan ◽  
Shuqin Yan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Drug Application ◽  
Surgical Excision ◽  
Skin Wound ◽  
Great Promise ◽  
Wound Healing Process ◽  
Polymer Scaffolds ◽  
Bioactive Substances ◽  
Cell Adhesion And Migration

Scars, as the result of abnormal wound-healing response after skin injury, may lead to loss of aesthetics and physical dysfunction. Current clinical strategies, such as surgical excision, laser treatment, and drug application, provide late remedies for scarring, yet it is difficult to eliminate scars. In this review, the functions, roles of multiple polymer scaffolds in wound healing and scar inhibition are explored. Polysaccharide and protein scaffolds, an analog of extracellular matrix, act as templates for cell adhesion and migration, differentiation to facilitate wound reconstruction and limit scarring. Stem cell-seeded scaffolds and growth factors-loaded scaffolds offer significant bioactive substances to improve the wound healing process. Special emphasis is placed on scaffolds that continuously release oxygen, which greatly accelerates the vascularization process and ensures graft survival, providing convincing theoretical support and great promise for scarless healing.

Perioperative Voice Recovery and the Vocal Folds: Perspectives From the Voice Care Team

2013 ◽  
Vol 23 (2) ◽  
pp. 53-60 ◽  
Author(s):  
Portone-Maira Carissa ◽  
M. Johns Michael
Keyword(s):  
Wound Healing ◽  
Vocal Fold ◽  
Healing Process ◽  
Vocal Folds ◽  
The Body ◽  
Matrix Remodeling ◽  
Matrix Deposition ◽  
Stomach Acid ◽  
Functional Consequences ◽  
Vocal Professionals

Information regarding the significance of wound healing in laryngology is steadily increasing. Vocal fold tissue may be injured by phonotrauma (excessive impact from the opposing vocal fold), chemical agents (e.g., stomach acid), trauma, or iatrogenic causes (i.e., intubation, vocal fold surgery). Following injury, the affected area becomes inflamed. The body initiates cell proliferation and matrix deposition to begin the process of healing. Matrix remodeling during the healing process determines the degree of scar formation. Vocal fold scar has well-documented structural and functional consequences, and is notoriously difficult to manage (Hirano, 2005). Our roles as vocal professionals in relationship to the stages of wound healing change at key time points: before creating a wound, when making a wound, acute management (0–2 weeks), subacute management (2–8 weeks), and late management (8 weeks and beyond)..

scholarly journals GAMBARAN PROSES RADANG LUKA POSTMORTEM PADA HEWAN COBA

2014 ◽  
Vol 2 (3) ◽  
Author(s):  
Patricius Geraldo Angel ◽  
Sonny Kalangi ◽  
Sunny Wangko
Keyword(s):  
Wound Healing ◽  
Human Body ◽  
Inflammatory Process ◽  
Healing Process ◽  
Time Frame ◽  
Fundamental Aspect ◽  
Wound Healing Process ◽  
Descriptive Research ◽  
In Series ◽  
Dermis Layer

Abstract: Skin is the largest and heaviest organ in human body. Its role as a barrier and its location at the surface of human body make it susceptible to trauma which in consequence to wound formation. Human body responses to wound by initiating wound healing process. The fundamental aspect of this process consists of four phases: inflammation, initiation, proliferation, and remodeling. In order to obtain sucessfull wound healing all four phases must occur in a proper sequence and a time frame. Several factors have been known to interfere one or more of these phases. In postmortem condition, wound healing can still occur but the process is different compared to those in antemortem condition. A domestic pig was used on account of the similarity in skin structure and histophysiology with human being to observe the inflammatory process in postmortem wounds. This was an experimental descriptive research. Cut wounds were made at the back of the postmortem pig then skin tissues were taken and reserved in series of time to observe histological features of wound healing process. The results showed that an increase of cells’ number in dermis layer of the skin was observed 15 minutes after the cut wounds. The increase of cells’ number in the first wounds reached its peak at 150 minutes postmortem, meanwhile the increase of cells’ number in second wounds reached its peak at 45 minutes postmortem, 90 minutes after the cut wounds were made. Moreover, the increase of cells’number could be observed until 3 hours postmortem. It was concluded that the inflammatory process of wound healing observed by increases of cells’ number still occured postmortem for a certain time. Keywords: Inflammatory process, postmortem, wound.     Abstrak: Kulit merupakan organ terbesar dan terberat dari tubuh manusia. Keberadaannya yang membungkus seluruh permukaan tubuh sebagai fungsi proteksi menyebabkan kulit rentan terhadap trauma dan terjadinya luka. Ketika terjadi luka, tubuh manusia akan merespon dengan memulai proses penyembuhan luka. Secara umum, proses penyembuhan luka terdiri dari empat fase, yaitu  fase inflamasi, inisiasi, proliferasi dan remodeling. Untuk terjadi penyembuhan luka dengan baik, fase penyembuhan luka ini harus berlangsung dengan urutan dan waktu yang tepat. Banyak faktor yang dapat mengganggu satu atau lebih fase ini. Dalam keadaan postmortem, penyembuhan luka masih dapat berlangsung, namun proses yang terjadi berbeda dengan penyembuhan luka sebelum kematian. Dalam penelitian ini digunakan babi domestik sebagai hewan coba karena babi  termasuk hewan omnivora dengan struktur dan histofisiologi kulit yang mirip manusia. Penelitian yang dilakukan merupakan jenis penelitian deskriptif eksperimental. Luka sayatan dibuat pada punggung babi setelah mati lalu jaringan kulit diambil dalam beberapa tahapan waktu untuk melihat gambaran histologik sebagai penanda radang dalam proses penyembuhan luka. Hasil penelitian memperlihatkan bahwa peningkatan jumlah sel pada lapisan dermis terlihat sejak 15 menit setelah terjadinya luka. Peningkatan jumlah sel pada luka tahap pertama berlanjut dan memuncak pada 150 menit postmortem. Peningkatan jumlah sel pada luka tahap kedua berlanjut dan memuncak pada 45 menit yang diambil 90 menit setelah pembuatan luka. Proses inflamasi yang dinilai dari peningkatan jumlah sel pada penelitian ini tetap berlangsung sampai 3 jam postmortem. Penelitian ini memperlihatkan bahwa reaksi inflamasi tetap berlangsung normal pada kondisi postmortem untuk suatu tenggang waktu tertentu. Kata kunci: Inflamasi, luka, postmortem.

HUBUNGAN MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST OPERASI SECTIO CESARIA

2019 ◽  
Vol 2 (1) ◽  
pp. 14-17
Author(s):  
Nurul Aini Siagian ◽  
Syafira Nusaibah ◽  
Andayani Boang Manalu
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Early Mobilization ◽  
Sectio Caesarea ◽  
Wound Healing Process ◽  
P Value ◽  
Cross Sectional ◽  
Care Services ◽  
Healing Wound ◽  
Rapid Healing

Early mobilization includes factors that can affect the process of wound healing after surgery. Immediate mobilization in stages is very useful for the process of healing wounds and preventing infection and venous thrombosis. The purpose of this study was to determine whether there is a relationship between early mobilization and the process of healing wound post operative sectio caesarea at Sinar Husni General Hospital Medan Helvetia. The research design used was analytic survey with cross sectional approach. The sample in this study used the Consecutive Sampling method of data collection using a checklist sheet conducted on a sample of 19 respondents. The results of the study in this study are the majority of respondents who did early mobilization and who experienced rapid wound healing process as many as 4 people (21%) while the minority of respondents who did early mobilization and who experienced slow wound healing process were 1 person (5.3%). The majority of respondents who did not mobilize early and who experienced a slow wound healing process were 11 people (57.9%) and a minority who did not mobilize early and who experienced rapid healing as many as 4 people (21.1%). Statistical test results obtained p value = 0.046 <0.005. The conclusions of the results of this study indicate there is a relationship between early mobilization and the process of healing post operative sectio of caesarea. Suggestions The results of this study can be applied as a reference to improve nursing care services, especially in providing counseling and assistance to patients.

Hubungan Status Gizi Dengan Proses Penyembuhan Luka Di Rsud H. Andi Sulthan Daeng Radja Kabupaten Bulukumba

2017 ◽  
Vol 2 (1) ◽  
pp. 20-28
Author(s):  
Fitriani ◽  
Tenriwati
Keyword(s):  
Wound Healing ◽  
Nutritional Status ◽  
Healing Process ◽  
Data Retrieval ◽  
Observational Research ◽  
Wound Healing Process ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

At present, the incidence of injuries in Indonesia is quite high, as seen from data on traffic accidents in the general public. There are several factors that affect wound healing, one of which is nutritional status. Based on the preliminary data retrieval conducted by researchers in the seruni surgery room in the last 1 month namely in March, it was found that the number of wounded patients was 109 patients, where the number of men was 78 (71.56%) while the number of women was 31 ( 28.44%) The purpose of this study was to determine the relationship between nutritional status and the wound healing process in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. This research uses the type of design of this research is quantitative research. This type of research uses analytic observational research with cross sectional approach. The sample of this study were 41 respondents taken by purposive sampling method. Data analysis in this study used the chi-square test (chi square test). The results of the analysis used the chi-square statistical test with a confidence level (α = 0.05). Based on the results of this test, the p value is 0.001, thus p <α (0.001 <0.05), then Ho is rejected and Ha is accepted. The conclusion of this study is that there is a relationship between nutritional status and the process of wound healing in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. Researchers suggest that this study be used as a material consideration in the fulfillment of nutrition in wound care patients in RSUD.H.A. Sulthan Daeng Radja Kab. Bulukumba and this research can be continued by conducting research related to the wound healing process and linking it with other variables.

Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

2020 ◽  
Vol 26 (36) ◽  
pp. 4551-4568
Author(s):  
Mohammad Kashif Iqubal ◽  
Sadaf Saleem ◽  
Ashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Growth Factors ◽  
Combination Therapy ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Site ◽  
Synthetic Drugs ◽  
Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

Scientific aspect on Diet explained by Susrutha in Wound Healing

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Manoj Kumar ◽  
Amareshappa . ◽  
Anjali Bharadwaj ◽  
Shailaja S. V.
Keyword(s):  
Wound Healing ◽  
Mineral Metabolism ◽  
Healing Process ◽  
Surgical Techniques ◽  
The Body ◽  
Wound Healing Process ◽  
Human Being ◽  
Different Sources ◽  
Scientific Aspect ◽  
Important Branch

Wound healing has been the burning problem in a surgical practice because of a remarkable increase in the number of traumatic cases. A wound causes a number of changes in the body that can affect the healing process, including changes in energy, protein, carbohydrate, fat, vitamin and mineral metabolism. Various Ayurveda literatures, particularly, Sushruta Samhita, which is said to be an ancient textbook of surgery in Ayurveda, has mentioned about the diet for the person suffering from the wound, and the author said that diet plays a very important role in the wound healing process. Sushruta - The father of surgery has scientifically classified it in a systemic manner, whose wealth of clinical material and the principles of management are valid even today. Shalya Tantra (surgical branch in Ayurveda Science) is one of the important branch of Ayurveda, in which surgical and para-surgical techniques has described for management of various diseases. Vrana is the most important and widely described chapter of Shalya Tantra. Vrana (wound) is one of them, which have been managed by human being from starting of civilization. Under the circumstances, the first thing which the men came across was the injury from different sources which caused him the Vrana. Vrana is seen as debilitating and scaring disorder, usually seen affecting the human being at any age. Well balanced nutrition plays an essential role in the wound healing.

PENGARUH MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST SECTIO CAESAREA

2017 ◽  
Vol 11 (1) ◽  
pp. 109
Author(s):  
Reni Heryani ◽  
Ardenny Denny
Keyword(s):  
Wound Healing ◽  
Placenta Previa ◽  
Healing Process ◽  
Early Mobilization ◽  
Sectio Caesarea ◽  
Uterine Action ◽  
Wound Healing Process ◽  
P Value ◽  
Post Test ◽  
Development Goals

<p align="center"><strong>A</strong><strong>BSTRAK</strong><strong></strong></p><p align="center"> </p><p>Salah satu tujuan pembangunan era <em>Millenium Development goals (MDG’s)</em> 2015 adalah perbaikan kesehatan maternal. Salah satu cara di dalam persalinan atau mengeluarkan bayi secara patologis yaitu dengan sectio caesarea. Menurut  statistik 3.509 kasus sectio caesarea, indikasi terbanyak adalah disproporsi cephalo pelvik (21%), sedangkan indikasi lain adalah gawat janin (14%), plasenta previa (11%), pernah sectio caesarea (11%), incoordinate uterine action (9%), preeklamsi dan hipertensi (7%). Penelitian ini menggunakan desain penelitian <em>Quasy Experiment</em> dengan <em>post test only with control.</em> Hasil penelitian menunjukkan bahwa umumnya responden memiliki umur tidak berisiko terhadap tindakan operasi yati sebanyak 15 orang (75%), sebagian responden pertama kali dilakukan operasi caesarea yaitu sebanyak 10 orang (50,0%), sebagian responden mengalami penyembuhan luka yang normal yaitu sebanyak 13 orang (65,0%), dan sebagian responden responden melakukan mobilisasi dini yaitu sebanyak 14  orang (70,0%). Secara statistik terdapat pengaruh mobilisasi dini terhadap penyembuhan luka post sectio caesarea di RSUD Arifin Achmad Pekanbaru (p value = 0.007). Disarankan bagi respnden dapat meningkatkan kesadarannya dalam meningkatkan derajat kesehatan melalui latihan mobilisasi dini untuk mempercepat proses penyembuhan luka akibat operasi.</p><p><em> </em></p><p><em>Kata Kunci      : </em><em>sectio </em><em>caesarea, mobilisasi, penyembuhan luka</em></p><p><em> </em></p><p align="center"><strong><em>ABSTRACT</em></strong></p><p><em> </em></p><p><em>One of the goals of development era of Millennium Development Goals (MDG's) in 2015 is the improvement of maternal health.</em><em> </em><em>One way in the delivery or the baby out with the pathological ie sectio caesarea. According to 3509 statistics compiled case sectio caesarea, an indication of cephalo pelvic disproportion is the highest (21%), while the other is an indication of fetal distress (14%), placenta previa (11%), never sectio caesarea (11%), incoordinate uterine action (9%), preeclampsia and hypertension (7%).</em><em> </em><em>This study research design quasy Experiment with post test only with control. The results showed that respondents generally have a lifespan of no risk for surgery yati many as 15 people (75%), the majority of respondents were first performed caesarea operation as many as 10 people (50.0%), the majority of respondents experienced a normal wound healing as many as 13 people (65.0%), and the majority of respondents respondents did early mobilization as many as 14 people (70.0%). There is a statistically significant relationship between early mobilization on wound healing post sectio caesarea (p value = 0.007). Suggested for respnden can increase awareness in improving health status through early mobilization exercises to accelerate the wound healing process as a result of the operation.</em></p><p><em> </em></p><em>Keywords: sectio caesarea, mobilization, wound healing</em>

scholarly journals Development of a Topical Insulin Polymeric Nanoformulation for Skin Burn Regeneration: An Experimental Approach

2021 ◽  
Vol 22 (8) ◽  
pp. 4087
Author(s):  
Maria Quitério ◽  
Sandra Simões ◽  
Andreia Ascenso ◽  
Manuela Carvalheiro ◽  
Ana Paula Leandro ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
In Vitro Release ◽  
Peptide Hormone ◽  
Plga Nanoparticles ◽  
Wound Healing Process ◽  
Target Area ◽  
Encapsulation Process

Insulin is a peptide hormone with many physiological functions, besides its use in diabetes treatment. An important role of insulin is related to the wound healing process—however, insulin itself is too sensitive to the external environment requiring the protective of a nanocarrier. Polymer-based nanoparticles can protect, deliver, and retain the protein in the target area. This study aims to produce and characterize a topical treatment for wound healing consisting of insulin-loaded poly-DL-lactide/glycolide (PLGA) nanoparticles. Insulin-loaded nanoparticles present a mean size of approximately 500 nm and neutral surface charge. Spherical shaped nanoparticles are observed by scanning electron microscopy and confirmed by atomic force microscopy. SDS-PAGE and circular dichroism analysis demonstrated that insulin preserved its integrity and secondary structure after the encapsulation process. In vitro release studies suggested a controlled release profile. Safety of the formulation was confirmed using cell lines, and cell viability was concentration and time-dependent. Preliminary safety in vivo assays also revealed promising results.

Sign in / Sign up

Export Citation Format

Share Document