Perioperative Voice Recovery and the Vocal Folds: Perspectives From the Voice Care Team

2013 ◽  
Vol 23 (2) ◽  
pp. 53-60 ◽  
Author(s):  
Portone-Maira Carissa ◽  
M. Johns Michael
Keyword(s):  
Wound Healing ◽  
Vocal Fold ◽  
Healing Process ◽  
Vocal Folds ◽  
The Body ◽  
Matrix Remodeling ◽  
Matrix Deposition ◽  
Stomach Acid ◽  
Functional Consequences ◽  
Vocal Professionals

Information regarding the significance of wound healing in laryngology is steadily increasing. Vocal fold tissue may be injured by phonotrauma (excessive impact from the opposing vocal fold), chemical agents (e.g., stomach acid), trauma, or iatrogenic causes (i.e., intubation, vocal fold surgery). Following injury, the affected area becomes inflamed. The body initiates cell proliferation and matrix deposition to begin the process of healing. Matrix remodeling during the healing process determines the degree of scar formation. Vocal fold scar has well-documented structural and functional consequences, and is notoriously difficult to manage (Hirano, 2005). Our roles as vocal professionals in relationship to the stages of wound healing change at key time points: before creating a wound, when making a wound, acute management (0–2 weeks), subacute management (2–8 weeks), and late management (8 weeks and beyond)..

Perioperative Voice Recovery: A Wound-Healing Perspective

2013 ◽  
Vol 23 (2) ◽  
pp. 42-46 ◽  
Author(s):  
Ryan C. Branski
Keyword(s):  
Wound Healing ◽  
Human Body ◽  
Vocal Fold ◽  
Healing Process ◽  
Surgical Excision ◽  
Vocal Folds ◽  
Favorable Outcome ◽  
Wound Healing Process ◽  
License Plate ◽  
Biochemical Processes

To describe the wound healing process through an oversimplified graphic, a classic cartoon in a Dermatology Clinics textbook shows a Volkswagen Beetle, with the license plate TRAUMA that has driven through a wooden fence, leaving both a substantive hole in the fence and piles of broken wooden planks. The obvious priority would be to rebuild the fence so that it is identical to its pretrauma state. This analogy and accompanying graphic provide a framework for a unique perspective on wound healing. For the sake of simplicity, let us assume that the vocal fold is a fence, and instead of a Volkswagen Beetle, the trauma is surgical excision of a vocal fold lesion. Immediately following surgery, the human body initiates the process of rebuilding vocal fold tissue. From a physiological perspective, it would be ideal to regain the original architecture of the vocal fold to ensure minimal alteration to phonatory physiology. Unfortunately, beyond the 2nd trimester of gestation, wounds heal with subsequent scarring. In the vocal folds, this scarring can have significant deleterious effects on vocal fold pliability and lead to dysphonia. However, investigators have shown that wounds heal regeneratively (i.e., no scarring) in the fetal environment. This observation provides potential targets for therapies to direct wound healing toward a more favorable outcome. In this article, I provide a brief overview of the biochemical processes associated with wound healing. Subsequently, I outline the underlying rationale for tissue mobilization in the context of acute vocal fold injury.

scholarly journals Green Peptide–nanomaterials; A Friendly Healing Touch for Skin Wound Regeneration

2019 ◽  
Vol 2 (1) ◽  
pp. 14-31 ◽  
Author(s):  
Debjani Nath ◽  
Pratyusha Banerjee ◽  
Anugrah Ray ◽  
Baishakhi Bairagi
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Healing Process ◽  
Skin Wound ◽  
The Body ◽  
Wound Healing Process ◽  
Present Moment ◽  
Developmental Study ◽  
Matrix Remodeling ◽  
Natural Peptides

The complex phenomenon by which the body responds to any injury of skin or tissue is known as wound healing. A number of phases like exudative, proliferative, and extracellular matrix remodeling are orchestrated events to be occurred involving blood cells, parenchymal cells, and different soluble mediators. Different internal, as well as external factors, regulate the speed and quality of healing. The delay in wound healing process causes the chronic wound or scar formation. At the present moment, the upscale research for identification of agents causing accelerated healing is important. Moreover, the biocompatibility of the accelerators needs to be investigated. Recent biomedical researches for wound care target to provide antimicrobial protection as well as matrix scaffolding for quick repairing of the skin tissue. In recent studies with natural peptides have shown that they are important components in developing the nano-medicines for their usefulness and therapeutic efficiency. New therapeutic formulations can be developed using these natural peptides utilizing different nanoparticle delivery system. This review deals with the developmental study on efficient wound care system where the possible use of natural peptides in combination with nanomaterials has been explored. A trial has also been made on the findings made over the past few years on the use of peptides as tissue regenerating agents through effective wound healing pathway.

Scientific aspect on Diet explained by Susrutha in Wound Healing

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Manoj Kumar ◽  
Amareshappa . ◽  
Anjali Bharadwaj ◽  
Shailaja S. V.
Keyword(s):  
Wound Healing ◽  
Mineral Metabolism ◽  
Healing Process ◽  
Surgical Techniques ◽  
The Body ◽  
Wound Healing Process ◽  
Human Being ◽  
Different Sources ◽  
Scientific Aspect ◽  
Important Branch

Wound healing has been the burning problem in a surgical practice because of a remarkable increase in the number of traumatic cases. A wound causes a number of changes in the body that can affect the healing process, including changes in energy, protein, carbohydrate, fat, vitamin and mineral metabolism. Various Ayurveda literatures, particularly, Sushruta Samhita, which is said to be an ancient textbook of surgery in Ayurveda, has mentioned about the diet for the person suffering from the wound, and the author said that diet plays a very important role in the wound healing process. Sushruta - The father of surgery has scientifically classified it in a systemic manner, whose wealth of clinical material and the principles of management are valid even today. Shalya Tantra (surgical branch in Ayurveda Science) is one of the important branch of Ayurveda, in which surgical and para-surgical techniques has described for management of various diseases. Vrana is the most important and widely described chapter of Shalya Tantra. Vrana (wound) is one of them, which have been managed by human being from starting of civilization. Under the circumstances, the first thing which the men came across was the injury from different sources which caused him the Vrana. Vrana is seen as debilitating and scaring disorder, usually seen affecting the human being at any age. Well balanced nutrition plays an essential role in the wound healing.

scholarly journals Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Hamed Nosrati ◽  
Reza Aramideh Khouy ◽  
Ali Nosrati ◽  
Mohammad Khodaei ◽  
Mehdi Banitalebi-Dehkordi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Tissue Regeneration ◽  
Molecular Mechanisms ◽  
Healing Process ◽  
The Body ◽  
Key Factors ◽  
Potential Applications ◽  
Nanocomposite Scaffolds

AbstractSkin is the body’s first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.

scholarly journals Investigating the Wound Healing Potential of the Polyherbal Gels Prepared with Ficus Extract

2018 ◽  
Vol 8 (2) ◽  
pp. 13-16
Author(s):  
Mahender K ◽  
Ravi D ◽  
Chaitanya Kumar K ◽  
Mothilal K
Keyword(s):  
Wound Healing ◽  
Inflammatory Response ◽  
Human Body ◽  
Healing Process ◽  
The Body ◽  
Wound Healing Process ◽  
Aqueous Extracts ◽  
Standard Drug ◽  
Carbopol Gel ◽  
Ficus Benghalensis

Wounds are nothing but any damage to the tissue or skin that can be healed. The wound healing process is usually built in the human body to self heal many wounds. When there is an injury in the body, there is an inflammatory response that is generated in the body, and the cells begin to raise the collagen levels in the skin which enables to increase the healing process. Ficus species of plants are famous for their potency to treat diseases in various Indian systems of medicine and the tree is commonly called as a banyan. Especially the plant in the species benghalensis is used to treat rheumatism, wounds and other skin related problems like an ulcer. The herbal gels were prepared using the incorporation of the aqueous extracts of the plant Ficus benghalensis into carbopol gel. They were investigated for the wound healing potential compared to the betadine drug standard. The gels at a concentration 200mg/g of the gel showed better activity compared to the gel at 100mg/g and the standard drug, betadine.

scholarly journals Effect of Carica papaya Extract toward Incised Wound Healing Process in Mice (Mus musculus) Clinically and Histologically

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Rachmi Fanani Hakim ◽  
Fakhrurrazi ◽  
Dinni
Keyword(s):  
Wound Healing ◽  
Mus Musculus ◽  
Carica Papaya ◽  
Healing Process ◽  
Antibacterial Properties ◽  
The Body ◽  
Wound Healing Process ◽  
Protective Function ◽  
Incised Wound ◽  
Anterior Teeth

Wound healing entails a sequence of complex biological processes, which is a protective function of the body that focuses on a quick recovery. Reducing wound healing time is crucial in a wound as it lowers the chance of infection and decreases complications and costs. Papaya extract was obtained by a maceration method. It contains papain enzyme, flavonoid, saponin, and alkaloid, which act as an anti-inflammatory, astringent substance, vasodilator, antioxidant, analgesic, with antifungal, and antibacterial properties, and increase the collagen synthesis. This study aimed to assess the effect of Carica papaya extract application toward incised wound healing process in mice (Mus musculus) clinically and histologically. This experimental laboratory study was performed using 24 mice weighing between 30 and 40 grams and 12 and 14 weeks of age as experimental animals. Each group was incised along 5 mm at the labial gingiva under both of mandible anterior teeth with a depth reaching alveolar bone. Papaya extract was applied topically in the morning and evening for 14 days. The clinical result was obtained by assessing the length of wound closure measured every day for 14 days. Based on the statistic test result, it showed that the papaya extract has a significant effect (p≤0.05) toward the healing process of an incised oral wound in mice. Histologically at day 14, 75% concentration papaya extract showed perfect epithelial layer and fibrillation.

Acute Histologic Effects of Extraesophageal Reflux on Vocal Fold Healing

2005 ◽  
Vol 114 (4) ◽  
pp. 296-303 ◽  
Author(s):  
Seth M. Cohen ◽  
C. Gaelyn Garrett ◽  
Shan Huang ◽  
Mark S. Courey
Keyword(s):  
Wound Healing ◽  
Analysis Of Variance ◽  
Vocal Fold ◽  
Saline Solution ◽  
Vocal Folds ◽  
Canine Model ◽  
Extraesophageal Reflux ◽  
Cellular Infiltrate ◽  
Acute Wound ◽  
Hematoxylin And Eosin

This study evaluates how extraesophageal reflux affects membranous vocal fold healing in a canine model. We created membranous vocal fold injuries in the animals and randomly assigned them to topical application of acid and pepsin at pH 2 or pH 6 or of normal saline solution every other day for 12 days. The experimental vocal folds were compared to uninjured, control vocal folds from animals painlessly sacrificed for other reasons. Hematoxylin and eosin, fibronectin, and procollagen I staining were performed for histologic analysis. The injured specimens had three times greater cellular infiltrate (p ≤ .001, analysis of variance) and twice as much fibronectin and procollagen I (p ≤ .001, analysis of variance) as did the specimens from the control animals. No significant differences or trends were identified for cellular infiltrate, fibronectin, or procollagen I within the injured groups (p > .05, Bonferroni t-test). Acute wound healing did not appear to be influenced by the presence of acid and pepsin at pH 2 or 6 as compared to saline solution.

Hepatocyte Growth Factor and its Receptor C-Met in Rat and Rabbit Vocal Folds

2002 ◽  
Vol 111 (8) ◽  
pp. 661-666 ◽  
Author(s):  
Shigeru Hirano ◽  
Susan Thibeault ◽  
Charles N. Ford ◽  
Diane M. Bless ◽  
Shin-Ichi Kanemaru
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Lamina Propria ◽  
Vocal Fold ◽  
Vocal Folds ◽  
Enzyme Linked Immunosorbent Assay ◽  
Alternative Approach ◽  
Fibrotic Scar ◽  
Hepatocyte Growth

Vocal fold fibrotic scar is characterized by fibrosis of the lamina propria and epithelium, and is difficult to treat. Hepatocyte growth factor (HGF) has antifibrotic activity and has received attention as a possible therapeutic alternative to treat fibrosis. In this study, in order to clarify whether HGF can be involved in vocal fold scarring, we examined the existence of HGF and its receptor, c-Met, in rat vocal folds, and then the activity of HGF in rabbit injured vocal folds, using immunohistochemistry and enzyme-linked immunosorbent assay. We found HGF and c-Met on epithelial cells and gland cells of the rat vocal folds. On the injured vocal folds of rabbits, little HGF was observed immediately after injury, but prominent activity occurred simultaneously with reepithelialization of the vocal fold mucosa on days 10 to 15. The activity of HGF was observed on fibroblasts in the lamina propria, as well as the epithelium. It is suggested that HGF in the vocal folds is produced by the fibroblasts and delivered to the epithelium. The implication of these findings is that HGF is involved in wound healing of the vocal fold, and may provide an alternative approach in preventing and treating vocal fold scarring.

scholarly journals The Effects of Wireless Micro Current Stimulation for Partial Thickness Burn Injury Treatment

1970 ◽  
Vol 1 (3) ◽  
Author(s):  
Defry Utama ◽  
Aditya Wardhana
Keyword(s):  
Wound Healing ◽  
Electrical Stimulation ◽  
Burn Injury ◽  
Healing Process ◽  
Case Series ◽  
Electrical Current ◽  
The Body ◽  
Transfer Energy ◽  
Partial Thickness ◽  
Partial Thickness Burn

Backgrounds: The body has its own bioelectric system that influences wound healing. Wireless Micro Current Stimulation (WMCS) or Electrical Stimulation (ES) is defined as the use of an electrical current to transfer energy to a wound. The type of electricity transferred is controlled by the electrical source. Although scarce, there have been studies proposing that this type of electricity increased healing rate of various wounds. However the effect of this electrical stimulation on burn wounds has not yet been studied.Patient and Methods: We present case series of superficial and deep partial thickness burns treated with ES and examine its effect on healing process. Six cases of second degree burn admitted to Cipto Mangunkusumo General Hospital (RSCM) from March–May 2011. They were chosen randomly to be treated with WMCS/ES. We applied the stimulation on the wound one hour daily. The wound was cleansed conventionally with moist gauze before and after the stimulation.Results: All the patients reported that they feel comfort during and after the application. We found epithelialization within 6 to 9 days. However we cannot determined if the WCMS/ES induce faster wound healing, because we do not compare it with other treatment. Summary: From six cases that we studied, we concluded that, the use of this WCMS/ES could have an effect of the epithelialization within 6-9 days. All the patients reported that they feel comfort during and after the application of WMCS/ES.

scholarly journals Hydrogels for management of chronic wound healing

2021 ◽  
Vol 5 (3) ◽  
pp. 095-104
Author(s):  
IM Cardoso-Daodu ◽  
CP Azubuike ◽  
MO Ilomuanya
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Healing Process ◽  
Three Dimensional ◽  
Scar Tissue ◽  
The Body ◽  
Polymer Chains ◽  
Wound Healing Process ◽  
Dimensional Network ◽  
Healing Wound

Chronic wounds occur when one wound healing process or a sequence of wound healing events are affected resulting in slow healing of the wound thereby placing the patient in deep pain. Various diseases and conditions can delay the process of wound healing. Wound healing can be classified into four main stages: hemostasis, inflammation, remodeling, and scar tissue formation with each phase overlapping one another. The skin is the largest organ in the body. It protects the entire external surface of the human body and is the primary site of interaction with the outside environment. There is therefore a need to fabricate an ideal dressing through scientific research and investigations. Hydrogels are a three-dimensional network of hydrophilic polymers that can swell in water and absorb copious amounts of water while maintaining their structure because of their chemical or physical crosslinking of individual polymer chains. A hydrogel must be composed of at least 10% water. Hydrogels possess the flexibility and water percentage which is remarkably like tissues. They are biocompatible and biodegradable which makes them ideal for dermal wound healing.

Sign in / Sign up

Export Citation Format

Share Document