Insulin growth factor-1 (IGF-1) enhances hippocampal excitatory and seizure activity through IGF-1 receptor-mediated mechanisms in the epileptic brain

2015 ◽  
Vol 129 (12) ◽  
pp. 1047-1060 ◽  
Author(s):  
Guohui Jiang ◽  
Wei Wang ◽  
Qingqing Cao ◽  
Juan Gu ◽  
Xiujuan Mi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Protein Kinase ◽  
Seizure Activity ◽  
Protein Kinase B ◽  
Akt Signaling ◽  
Insulin Like Growth Factor ◽  
Insulin Growth Factor ◽  
Extracellular Signal

Insulin-like growth factor-1 (IGF-1) enhances hippocampal excitatory and seizure activity via IGF-1 receptor (IGF-1R) mediated extracellular signal-related kinase (ERK)-1/2 and protein kinase B (Akt) signaling in the epileptic brain, which suggests that IGF-1R may represent a new target in the search for antiepileptic strategies.

scholarly journals Vitamin D3 Activates Phosphatidylinositol-3-Kinase/Protein Kinase B via Insulin-Like Growth Factor-1 to Improve Testicular Function in Diabetic Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Yanyan He ◽  
Yang Liu ◽  
Qing-Zhu Wang ◽  
Feng Guo ◽  
Fengjuan Huang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Growth Factor ◽  
Protein Kinase ◽  
Protein Kinase B ◽  
Diabetic Rats ◽  
Testicular Function ◽  
Insulin Like Growth Factor ◽  
Wild Type ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

Objective. In diabetes mellitus, vitamin D3 deficiency affects sex hormone levels and male fertility; however, the mechanism leading to the disorder is unclear. This research was designed to investigate the mechanism of vitamin D3 deficiency and hypogonadism in diabetic rats. Our aim was to assess serum vitamin D3 levels and the relationship among vitamin D3, insulin-like growth factor-1 (IGF-1), and testicular function. Materials and Methods. Rats with streptozotocin-induced diabetes were randomly divided into four groups and treated with different doses of vitamin D3: no vitamin D3, low (0.025 μg/kg/day), high (0.1 μg/kg/day), and high (0.1 μg/kg/day) with JB-1 (the insulin-like growth factor-1 receptor inhibitor group, 100 μg/kg/day). The groups were compared with wild-type rats, which function as the control group. Various parameters such as vitamin D3 and IGF-1 were compared between the experimental and wild-type groups, and their correlations were determined. Results. Twelve weeks of vitamin D3 supplementation improved the testosterone levels, as shown by the increase in the level of serum IGF-1 in diabetic rats. Phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT), which was a downstream of the signaling pathway of IGF-1, was significantly increased after vitamin D3 treatment. Conclusions. The study shows that vitamin D3 may promote the expression of testosterone and improve testicular function in diabetic rats by activating PI3K/AKT via IGF-1.

scholarly journals Differential Activation of Protein Kinase B and p70S6Kby Glucose and Insulin-like Growth Factor 1 in Pancreatic β-Cells (INS-1)

2001 ◽  
Vol 276 (24) ◽  
pp. 21110-21120 ◽  
Author(s):  
Lorna M. Dickson ◽  
Melissa K. Lingohr ◽  
Jill McCuaig ◽  
Sigrun R. Hügl ◽  
Lynn Snow ◽  
...  
Keyword(s):  
Growth Factor ◽  
Protein Kinase ◽  
Protein Kinase B ◽  
Insulin Like Growth Factor ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Differential Activation
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