Insulin-Like Growth Factor Type-I Receptor-Dependent Phosphorylation of Extracellular Signal-Regulated Kinase 1/2 but not Akt (Protein Kinase B) Can Be Induced by Picropodophyllin

2007 ◽  
Vol 73 (3) ◽  
pp. 930-939 ◽  
Author(s):  
Radu Vasilcanu ◽  
Daiana Vasilcanu ◽  
Bita Sehat ◽  
Shucheng Yin ◽  
Ada Girnita ◽  
...  
Keyword(s):  
Growth Factor ◽  
Protein Kinase ◽  
Protein Kinase B ◽  
Type I ◽  
Insulin Like Growth Factor ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Factor Type

Insulin growth factor-1 (IGF-1) enhances hippocampal excitatory and seizure activity through IGF-1 receptor-mediated mechanisms in the epileptic brain

2015 ◽  
Vol 129 (12) ◽  
pp. 1047-1060 ◽  
Author(s):  
Guohui Jiang ◽  
Wei Wang ◽  
Qingqing Cao ◽  
Juan Gu ◽  
Xiujuan Mi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Protein Kinase ◽  
Seizure Activity ◽  
Protein Kinase B ◽  
Akt Signaling ◽  
Insulin Like Growth Factor ◽  
Insulin Growth Factor ◽  
Extracellular Signal

Insulin-like growth factor-1 (IGF-1) enhances hippocampal excitatory and seizure activity via IGF-1 receptor (IGF-1R) mediated extracellular signal-related kinase (ERK)-1/2 and protein kinase B (Akt) signaling in the epileptic brain, which suggests that IGF-1R may represent a new target in the search for antiepileptic strategies.

scholarly journals Impaired Hepatocyte DNA Synthetic Response Posthepatectomy in Insulin-Like Growth Factor Binding Protein 1-Deficient Mice with Defects in C/EBPβ and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Regulation

2003 ◽  
Vol 23 (4) ◽  
pp. 1251-1259 ◽  
Author(s):  
Julia I. Leu ◽  
Mary Ann S. Crissey ◽  
Linden E. Craig ◽  
Rebecca Taub
Keyword(s):  
Cell Cycle ◽  
Growth Factor ◽  
Protein Kinase ◽  
Liver Regeneration ◽  
Mitogen Activated Protein Kinase ◽  
Insulin Like Growth Factor ◽  
Extracellular Signal Regulated Kinase ◽  
Factor Binding ◽  
Extracellular Signal ◽  
Mitogen Activated Protein

ABSTRACT After a two-thirds hepatectomy, normally quiescent liver cells are stimulated to reenter the cell cycle and proliferate to restore the original liver mass. One of the most rapidly and highly induced genes and proteins in regenerating liver is insulin-like growth factor binding protein 1 (IGFBP-1), a secreted protein that may modulate the activities of insulin-like growth factors (IGFs) or signal via IGF-independent mechanisms. To assess the functional role of IGFBP-1 in liver regeneration, mice with a targeted disruption of the IGFBP-1 gene were generated. Although IGFBP-1−/− mice demonstrated normal development, they had abnormal liver regeneration after partial hepatectomy, characterized by liver necrosis and reduced and delayed hepatocyte DNA synthesis. The abnormal regenerative response was associated with blunted activation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and a reduced induction of C/EBPβ protein expression posthepatectomy. Like cell cycle abnormalities observed in hepatectomized C/EBPβ−/− mice, cyclin A and cyclin B1 expression was delayed and reduced in IGFBP-1−/− livers, whereas cyclin D1 expression was normal. Treatment of IGFBP-1−/− mice with a preoperative dose of IGFBP-1 induced MAPK/ERK activation and C/EBPβ expression, suggesting that IGFBP-1 may support liver regeneration at least in part via its effect on MAPK/ERK and C/EBPβ activities. These findings are the first demonstration of the involvement of IGFBP-1 in the regulation of in vivo mitogenic signaling pathways.

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