Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma

2015 ◽  
Vol 128 (11) ◽  
pp. 761-774 ◽  
Author(s):  
Teng Feng ◽  
Johanna Dzieran ◽  
Xing Gu ◽  
Silke Marhenke ◽  
Arndt Vogel ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Outcome ◽  
Mouse Model ◽  
Liver Damage ◽  
Mouse Liver ◽  
Human Hepatocellular Carcinoma ◽  
Hepatocyte Proliferation ◽  
Smad7 Expression ◽  
Dependent Mechanism

In an early liver damage mouse model, Smad7 induced compensatory hepatocyte proliferation. High Smad7 expression was associated with better prognosis in human hepatocellular carcinoma, especially in distinct subgroups. A YB-1 dependent mechanism was involved in Smad7 up-regulation in HCC.

scholarly journals Human Hepatocellular Carcinoma in a Mouse Model: Assessment of Tumor Response to Percutaneous Ablation by Using Glyceraldehyde-3-Phosphate Dehydrogenase Antagonists

Radiology ◽  
2012 ◽  
Vol 262 (3) ◽  
pp. 834-845 ◽  
Author(s):  
Shanmugasundaram Ganapathy-Kanniappan ◽  
Rani Kunjithapatham ◽  
Michael S. Torbenson ◽  
Pramod P. Rao ◽  
Kathryn A. Carson ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mouse Model ◽  
Tumor Response ◽  
Human Hepatocellular Carcinoma ◽  
Percutaneous Ablation ◽  
Model Assessment

scholarly journals MEP1A contributes to tumor progression and predicts poor clinical outcome in human hepatocellular carcinoma

Hepatology ◽  
2016 ◽  
Vol 63 (4) ◽  
pp. 1227-1239 ◽  
Author(s):  
Han-Yue OuYang ◽  
Jing Xu ◽  
Jun Luo ◽  
Ru-Hai Zou ◽  
Keng Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Outcome ◽  
Tumor Progression ◽  
Human Hepatocellular Carcinoma ◽  
Poor Clinical Outcome

Novel HCV replication mouse model using human hepatocellular carcinoma xenografts

2009 ◽  
Vol 84 (1) ◽  
pp. 14-22 ◽  
Author(s):  
Carl Guévin ◽  
Alain Lamarre ◽  
Patrick Labonté
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mouse Model ◽  
Human Hepatocellular Carcinoma

scholarly journals Fate and characterization of circulating tumor cells in a NOD/SCID mouse model of human hepatocellular carcinoma

Oncogene ◽  
2006 ◽  
Vol 25 (29) ◽  
pp. 4067-4075 ◽  
Author(s):  
O Scatton ◽  
F Chiappini ◽  
P Riou ◽  
A Marconi ◽  
R Saffroy ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mouse Model ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Scid Mouse ◽  
Human Hepatocellular Carcinoma ◽  
Scid Mouse Model
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