Glucocorticosteroid status in chronic alcoholics with and without skeletal muscle myopathy

1987 ◽  
Vol 73 (6) ◽  
pp. 601-603 ◽  
Author(s):  
P. Duane ◽  
T. J. Peters
Keyword(s):  
Skeletal Muscle ◽  
Serum Cortisol ◽  
Chronic Alcoholism ◽  
Muscle Fibres ◽  
Type Ii ◽  
Urinary Cortisol ◽  
Chronic Alcoholic ◽  
Alcoholic Myopathy ◽  
Urinary Cortisol Excretion ◽  
Skeletal Muscle Fibres

1. Chronic alcoholism is associated with a selective atrophy of type II skeletal muscle fibres. We studied the glucocorticoid status of chronic alcoholics with and without myopathy to determine if hypercortisolism is responsible for the myopathy. 2. Twenty-four hour urinary Cortisol excretion and diurnal serum Cortisol measurements were not significantly different in chronic alcoholics, with and without atrophy of type II skeletal muscle fibres. 3. Diurnal serum Cortisol variation was normal for both groups of alcoholics studied. None of the patients with myopathy had raised serum Cortisol levels. 4. We conclude that chronic alcoholic myopathy is not due to alcohol-related pseudo-Cushing's syndrome.

scholarly journals Contractile properties and sarcoplasmic reticulum calcium content in type I and type II skeletal muscle fibres in active aged humans

2015 ◽  
Vol 593 (11) ◽  
pp. 2499-2514 ◽  
Author(s):  
C. R. Lamboley ◽  
V. L. Wyckelsma ◽  
T. L. Dutka ◽  
M. J. McKenna ◽  
R. M. Murphy ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Calcium Content ◽  
Contractile Properties ◽  
Muscle Fibres ◽  
Type I ◽  
Type Ii ◽  
Skeletal Muscle Fibres ◽  
Sarcoplasmic Reticulum Calcium

Serum carnosinase activities in patients with alcoholic chronic skeletal muscle myopathy

1988 ◽  
Vol 75 (2) ◽  
pp. 185-190 ◽  
Author(s):  
P. Duane ◽  
T. J. Peters
Keyword(s):  
Skeletal Muscle ◽  
Enzyme Activity ◽  
Enzyme Activities ◽  
Muscle Fibres ◽  
Significant Activity ◽  
Type Ii ◽  
Normal Muscle ◽  
Serum Enzyme ◽  
Chronic Alcoholic ◽  
Muscle Biopsies

1. Serum carnosinase activity was assayed in a group of alcoholic patients with and without histologically proven atrophy of type II skeletal muscle fibres, and in control subjects. No significant activity was detected in muscle biopsy samples or washed erythrocytes. 2. Serum carnosinase activity was significantly lower in chronic alcoholic patients compared with a group of age-matched controls. Alcoholics with abnormal muscle biopsies had significantly lower enzyme activities than either those patients with normal muscle biopsies or the controls. Serum enzyme activities in patients with normal muscle biopsies were not significantly different from controls. 3. Serum carnosinase activity was inversely correlated with the degree of muscle atrophy as measured by the type II fibre atrophy factor. There was a positive correlation between the enzyme activity and skeletal muscle mass as reflected by the creatinine-height index. Furthermore, the enzyme activity significantly increased, with resolution or improvement in the myopathy, in patients who abstained from alcohol. 4. Kinetic studies showed that the reduced carnosinase activity was due mainly to a decrease in the apparent Vmax. The apparent Km was significantly higher in the myopathic compared with non-myopathic alcoholics. Mixing serum from controls and patients with myopathy gave the expected values, indicating the absence of a serum enzyme inhibitory factor. Acute alcohol loading had no effect on the serum carnosinase activity. 5. The decrease in serum carnosinase activity in alcoholics was not related to the severity of their liver disease. Assays of serum carnosinase in chronic alcoholics can thus be used as a marker of their associated myopathy.

Interferon-gamma-like immunoreactivity and T-cell marker expression in rat skeletal muscle fibres

1989 ◽  
Vol 504 (2) ◽  
pp. 306-310 ◽  
Author(s):  
Inger Nennesmo ◽  
Tomas Olsson ◽  
Åke Ljungdahl ◽  
Krister Kristensson ◽  
Peter H. Van der Meide
Keyword(s):  
Skeletal Muscle ◽  
T Cell ◽  
Interferon Gamma ◽  
Muscle Fibres ◽  
Cell Marker ◽  
Rat Skeletal Muscle ◽  
Marker Expression ◽  
Skeletal Muscle Fibres
Sign in / Sign up

Export Citation Format

Share Document