scholarly journals Endogenous and maximal sarcoplasmic reticulum calcium content and calsequestrin expression in type I and type II human skeletal muscle fibres

2013 ◽  
Vol 591 (23) ◽  
pp. 6053-6068 ◽  
Author(s):  
C. R. Lamboley ◽  
R. M. Murphy ◽  
M. J. McKenna ◽  
G. D. Lamb
Keyword(s):  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Human Skeletal Muscle ◽  
Calcium Content ◽  
Muscle Fibres ◽  
Type I ◽  
Type Ii ◽  
Skeletal Muscle Fibres ◽  
Sarcoplasmic Reticulum Calcium

scholarly journals Contractile properties and sarcoplasmic reticulum calcium content in type I and type II skeletal muscle fibres in active aged humans

2015 ◽  
Vol 593 (11) ◽  
pp. 2499-2514 ◽  
Author(s):  
C. R. Lamboley ◽  
V. L. Wyckelsma ◽  
T. L. Dutka ◽  
M. J. McKenna ◽  
R. M. Murphy ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Calcium Content ◽  
Contractile Properties ◽  
Muscle Fibres ◽  
Type I ◽  
Type Ii ◽  
Skeletal Muscle Fibres ◽  
Sarcoplasmic Reticulum Calcium

scholarly journals Differential regulation of the fiber type-specific gene expression of the sarcoplasmic reticulum calcium-ATPase isoforms induced by exercise training

2014 ◽  
Vol 117 (5) ◽  
pp. 544-555 ◽  
Author(s):  
Marc P. Morissette ◽  
Shanel E. Susser ◽  
Andrew N. Stammers ◽  
Kimberley A. O'Hara ◽  
Phillip F. Gardiner ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Exercise Training ◽  
Calcium Atpase ◽  
Specific Gene ◽  
Type I ◽  
Fiber Types ◽  
Type Ii ◽  
Type Ii Fibers ◽  
Sarcoplasmic Reticulum Calcium

The regulatory role of adenosine monophosphate-activated protein kinase (AMPK)-α2 on sarcoplasmic reticulum calcium-ATPase (SERCA) 1a and SERCA2a in different skeletal muscle fiber types has yet to be elucidated. Sedentary (Sed) or exercise-trained (Ex) wild-type (WT) and AMPKα2-kinase dead (KD) transgenic mice, which overexpress a mutated and inactivated AMPKα2 subunit, were utilized to characterize how genotype or exercise training influenced the regulation of SERCA isoforms in gastrocnemius. As expected, both Sed and Ex KD mice had >40% lower AMPK phosphorylation and 30% lower SERCA1a protein than WT mice ( P < 0.05). In contrast, SERCA2a protein was not different among KD and WT mice. Exercise increased SERCA1a and SERCA2a protein content among WT and KD mice, compared with their Sed counterparts. Maximal SERCA activity was lower in KD mice, compared with WT. Total phospholamban protein was higher in KD mice than in WT and lower in Ex compared with Sed mice. Exercise training increased phospholamban Ser16 phosphorylation in WT mice. Laser capture microdissection and quantitative PCR indicated that SERCA1a mRNA expression among type I fibers was not altered by genotype or exercise, but SERCA2a mRNA was increased 30-fold in WT+Ex, compared with WT+Sed. In contrast, the exercise-stimulated increase for SERCA2a mRNA was blunted in KD mice. Exercise upregulated SERCA1a and SERCA2a mRNA among type II fibers, but was not altered by genotype. Collectively, these data suggest that exercise differentially influences SERCA isoform expression in type I and type II fibers. Additionally, AMPKα2 influences the regulation of SERCA2a mRNA in type I skeletal muscle fibers following exercise training.

scholarly journals Ca2+leakage out of the sarcoplasmic reticulum is increased in type I skeletal muscle fibres in aged humans

2015 ◽  
Vol 594 (2) ◽  
pp. 469-481 ◽  
Author(s):  
C. R. Lamboley ◽  
V. L. Wyckelsma ◽  
M. J. McKenna ◽  
R. M. Murphy ◽  
G. D. Lamb
Keyword(s):  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Muscle Fibres ◽  
Type I ◽  
Skeletal Muscle Fibres

Low sulphur content in atrophied human skeletal muscle: an electron probe X-ray microanalytical study

1978 ◽  
Vol 36 (2) ◽  
pp. 634-635
Author(s):  
R. Wróblewski ◽  
W. Gremski ◽  
G. M. Roomans ◽  
R. Nordemar ◽  
L. Edström
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Control Group ◽  
Muscle Fibres ◽  
Type I ◽  
Tissue Preparation ◽  
Type Ii ◽  
Slow Twitch ◽  
Fibre Typing ◽  
Fast Twitch

Many diseases of the human skeletal muscle involve an atrophy of the muscle fibres. In some cases mainly one of the fibre types is affected. The fibre typing system used in this study is that of Padykula and Herman, 1955 and distinguishes between type I fibres which presumably correspond to the slow-twitch fibres and type II fibres which are the fast-twitch fibres. The type II fibres can be divided into type II A, II B and II C fibres. Recent advances in instrumentation and tissue preparation have permitted an investigation of the elemental composition of individual muscle fibres of known fibre type with the aim of comparing healthy and atrophied muscle fibres.In this study we have examined ten patients suffering from rheumatoid arthritis, two patients suffering from Parkinson's disease and two patients with upper motor lesions. As a control group we have examined muscles from eight healthy controls of the same age.

Sarcoplasmic reticulum ATPase activity in type I and II skeletal muscle fibres of chronic heart failure patients

2009 ◽  
Vol 133 (2) ◽  
pp. 185-190 ◽  
Author(s):  
Martijn A. Bekedam ◽  
Brechje J. van Beek-Harmsen ◽  
Willem van Mechelen ◽  
Anco Boonstra ◽  
Frans C. Visser ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Chronic Heart Failure ◽  
Sarcoplasmic Reticulum ◽  
Atpase Activity ◽  
Muscle Fibres ◽  
Type I ◽  
Heart Failure Patients ◽  
Skeletal Muscle Fibres

The effect of 4 weeks β-alanine supplementation and isokinetic training on carnosine concentrations in type I and II human skeletal muscle fibres

2009 ◽  
Vol 106 (1) ◽  
pp. 131-138 ◽  
Author(s):  
Iain P. Kendrick ◽  
Hyo Jeong Kim ◽  
Roger Charles Harris ◽  
Chang Keun Kim ◽  
Viet H. Dang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Muscle Fibres ◽  
Type I ◽  
Isokinetic Training ◽  
Skeletal Muscle Fibres

scholarly journals A New Myofibrillar Protein Characteristic of Type I Human Skeletal Muscle Fibres

1983 ◽  
Vol 132 (3) ◽  
pp. 657-662 ◽  
Author(s):  
Claus W. HEIZMANN ◽  
Marco R. CELIO ◽  
Rudolf BILLETER ◽  
Ursula REIST ◽  
Maria-Luisa MORET ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Myofibrillar Protein ◽  
Muscle Fibres ◽  
Type I ◽  
Skeletal Muscle Fibres
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