Blood Pressure and Casual Urine Electrolytes in 93 London Factory Workers

1983 ◽  
Vol 65 (3) ◽  
pp. 243-245 ◽  
Author(s):  
Kay Tee Khaw
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Urine Samples ◽  
Factory Workers ◽  
Sodium Potassium ◽  
Dynamic Relationship ◽  
Urine Electrolytes

1. A survey of blood pressure in 93 male London factory workers found a significant correlation between individual systolic blood pressure and sodium/creatinine and sodium/potassium ratios estimated from casual urine samples. 2. Casual urine samples may have value in assessing the dynamic relationship between blood pressure and electrolytes.

Abstract P053: Sodium and Potassium Intake and Blood Pressure and Risk of Hypertension Among U.S. Adults - Results From NHANES 2003-2008

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Zefeng Zhang ◽  
Mary Cogswell ◽  
Cathleen Gillespie ◽  
Jing Fang ◽  
Shifan Dai ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Sodium Potassium ◽  
Potassium Intake ◽  
Undiagnosed Hypertension ◽  
Unit Increase ◽  
Nationally Representative ◽  
Prevention Of Hypertension ◽  
Sodium And Potassium

Introduction: Evidence from randomized controlled trials demonstrates higher sodium and/or lower potassium intake increase blood pressure and the risk of hypertension. However, the relationship between sodium, potassium and blood pressure has not been examined using nationally representative sample and estimated usual intakes of these nutrients. Hypothesis: We hypothesized that usual sodium and potassium intake have opposing effects on blood pressure and a higher sodium-to-potassium ratio is associated with elevated blood pressure and hypertension. Methods: We analyzed data on 12,854 participants aged 20 years and older from the 2003-2008 National Health and Nutrition Examination Surveys. We estimated the usual intakes of sodium and potassium from the diet accounting for measurement error. Mean blood pressure was calculated from up to three readings on each subject and hypertension included both diagnosed and undiagnosed hypertension. We used multivariable linear regression to examine the associations between intakes of sodium, potassium and their ratio with systolic and diastolic blood pressure, and logistic regression for associations with hypertension. Results: The average estimated usual intakes of sodium and potassium were 3465 and 2741 mg/d, respectively. The average sodium-to-potassium ratio was 1.39; higher ratios were observed among males, younger and non-Hispanic black participants. After adjustment for potential confounders, usual intakes of sodium, potassium and their ratio were significantly associated with systolic blood pressure, with an increase of 1.08 mm Hg (95% confidence interval (CI): 0.30 – 1.86) and a decrease of 1.47 mmHg (95% CI: -2.31, -0.63) for every 1000 mg/d increase in sodium and potassium intake, respectively, and an increase of 2.80 mmHg (95% CI: 0.90 - 4.70) for every unit increase in sodium-to-potassium ratio. No association was found for diastolic blood pressure. The adjusted odds ratio (OR) comparing the highest and lowest quartiles of usual sodium or potassium intakes were 1.63 (95% CI: 1.14 - 2.34) and 0.61 (95% CI: 0.45 - 0.82), respectively, for risk of hypertension. For sodium-to-potassium ratio, the adjusted OR was 1.49 (95% CI: 1.17 - 1.89). The patterns of association were largely consistent across age, gender, race/ethnicity, body mass index, and education subgroups. Conclusions: In conclusion, our results indicated higher sodium and lower potassium intakes were associated with increased systolic blood pressure and risk for hypertension. The combined effect of sodium and potassium might play a central role in the pathogenesis of hypertension. The results further confirm that reducing sodium and increasing potassium intakes concurrently may have important implications in the prevention of hypertension, and hence, of cardiovascular disease.

Abstract P093: Sex-stratified Associations Of Urine Electrolytes With 10th & 90th Percentiles Of Systolic Blood Pressure Distribution

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Abu Mohd Naser ◽  
Mahbubur Rahman ◽  
Alvaro Alonso ◽  
Viola Vaccarino ◽  
Matthew Gribble
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Systolic Blood Pressure ◽  
Household Wealth ◽  
Limited Data ◽  
Urine Sodium ◽  
Conditional Mean ◽  
Coastal Bangladesh ◽  
Urine Electrolytes

Introduction: Electrolytes intake influence systolic blood pressure (SBP). Studies often explore the association of urine electrolytes with the conditional mean difference of SBP, but limited data exist on the sex-specific associations of urine electrolytes’ excretion with low and high end SBP distribution. We examined the sex-stratified association of urine electrolytes with the 10th and 90th percentiles of SBP. Methods: We pooled 9,804 person-visits (n =1467 participants) data of 24-hour urine electrolytes and SBP from three cohorts in coastal Bangladesh. We created sex-stratified restricted cubic spline (RCS) plots from quantile regression for illustrating the associations of urine sodium (Na), potassium (K), calcium (Ca), and magnesium (Mg) excretion with the 10th and 90th percentile of SBP distribution, adjusted for age, body mass index, physical activity, smoking, alcohol consumption, sleep hours, religion, household wealth, cohort ID, and seasonality. Four knots at the 5th, 35th, 65th, and 95th percentiles of each electrolyte distribution were used to create RCS plots. Results: We found linear positive associations for urine Na with 10th and 90th percentiles of SBP for males, but such association for the 10th percentile of SBP for females was less steep. Negative associations were found between urine K and SBP for males for the 90th percentile of SBP; no such association was found for the 10th percentile of SBP. Linear negative associations were found between urine Mg and SBP for males for both the 10th and 90th percentile of SBP distributions, but not for females. There was no association of urine Ca and SBP for both sexes for the 10th percentile of SBP, but negative associations existed for the 90th percentile of SBP for males. Conclusion: Sex-specific associations of urine electrolytes and SBP varied for the low and high end of SBP distribution. Males with higher SBP could benefit from high urine K, Ca, and Mg, representing high intakes of these minerals. However, such benefits may not be present for females.

EFFECT OF ALDOSTERONE IN A CASE OF HYPOALDOSTERONISM

1960 ◽  
Vol XXXIII (IV) ◽  
pp. 511-519 ◽  
Author(s):  
Bernt Hökfelt ◽  
Bengt Skanse
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Systolic Blood Pressure ◽  
Serum Sodium ◽  
Serum Potassium ◽  
Sodium Intake ◽  
Potassium Excretion ◽  
Sodium Potassium ◽  
Original Diagnosis ◽  
Body Weight Increase

ABSTRACT A patient previously described by the present authors as having selective hypoaldosteronism has been studied more extensively with special reference to the effect of aldosterone. Additional evidence has also been obtained in support of the original diagnosis of selective hypoaldosteronism. With the patient on a constant sodium intake, aldosterone intramuscularly or intravenously in a dose of 500 to 1000 μg a day was followed by retention of sodium and chloride, gain in body weight, increase in systolic blood pressure, and a rise in the serum sodium. Potassium excretion was increased throughout the period of aldosterone administration. The serum potassium showed a slight decrease. Similar effects were noted on administration of fluorohydrocortisone.

Artemisia restores systolic blood pressure, attenuates serum sodium/potassium levels and prevents cardiac oxidative stress in hypertension

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Khaled M.M. Koriem ◽  
Hend N. Saleh ◽  
Marwa A. El-Attar
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Oral Administration ◽  
Systolic Blood Pressure ◽  
Serum Sodium ◽  
Oral Intake ◽  
The Body ◽  
Sodium Potassium ◽  
Content Type ◽  
Sodium And Potassium

Purpose This paper aims to evaluate systolic blood pressure (SBP), serum sodium/potassium levels and cardiac antioxidants after Artemisia herba-alba oral administration in spontaneous hypertensive rats (SHR). Design/methodology/approach Hypertension is a silent killer disease. The SHR model was used in this study due to the similarity of high blood pressure in human and rat. The SBP, serum sodium and potassium, urinary sodium and potassium, cardiac antioxidants and heart histology were examined in SHR after oral administration with 10 and 20% of the LD50 of Artemisia herba-alba during four weeks. Findings The LD50 of Artemisia herba-alba was found to be 1000 mg/kg. Doses of 100 mg/kg (10% LD50) and 200 mg/kg (20% LD50) were considered in the present study. The oral administration of SHR rats with Artemisia extract at 100 and 200 mg/kg decreased (p < 0.01) the body weights, SBP and serum sodium and potassium. Meanwhile, cardiac superoxide dismutase and gluthatione peroxidase were increased in SHR-treated rats. Histology of SHR cardiac tissues showed tissue degenerative but oral intake of 100 and 200 mg/kg artemisia exhibited normal muscle fibers, acidophilic cytoplasm and central nuclei. Originality/value The cardiovascular diseases are the first reason for high death rate in Western countries and collapsing economies due to hypertensive patients suffering high health-care costs. The advantage of hypertension Herba l treatment occurred due to its cheap and available source. Artemisia herba-alba leaves restored SBP, attenuated serum sodium/potassium levels and prevented cardiac oxidative stress in SHR.

Plasma active and acid-activatable renin during the development of one-kidney, one-clip and two-kidney, one-clip hypertension in the rabbit

1991 ◽  
Vol 69 (9) ◽  
pp. 1375-1380 ◽  
Author(s):  
A. R. Noble ◽  
H. K. Richards
Keyword(s):  
Blood Pressure ◽  
Water Balance ◽  
Renal Artery ◽  
Systolic Blood Pressure ◽  
Surgical Procedures ◽  
Similar Data ◽  
Sodium Potassium ◽  
Ear Artery ◽  
Laparotomy Group ◽  
Inactive Renin

Systolic blood pressure in the central ear artery of eight rabbits increased by 21 mmHg (1 mmHg = 133.32 Pa) over 40 days following renal artery clipping and contralateral nephrectomy (one-kidney, one-clip). Plasma active and acid-activatable (pH 2.8) renin did not change significantly. Similar data were obtained from a group of 12 rabbits following renal artery clipping alone (two-kidney, one-clip) except that blood pressure in this group increased for 26 days but then declined until 40 days. Two animals with one-kidney, one-clip hypertension and three rabbits with two-kidney, one-clip hypertension had large increases in plasma active and inactive renin levels, which followed a more exaggerated rise in blood pressure than in the previous two groups. Forty days after unilateral renal artery clipping, the unclipped kidney was removed in 10 animals with two-kidney, one-clip hypertension. A further increase in blood pressure (+29%) occurred in seven of the animals but no change in plasma active or inactive renin. Results were compared with two groups of control animals, a unilateral nephrectomy group and a laparotomy group. None of the surgical procedures used produced a consistent pattern of change in the relative amounts of active and inactive renin in plasma. No marked changes in sodium, potassium, or water balance occurred in any group of animals.Key words: renovascular hypertension, renin, inactive renin, prorenin, rabbit.

Relationship between 24-h urine sodium/potassium ratio and central aortic systolic blood pressure in hypertensive patients

2016 ◽  
Vol 40 (4) ◽  
pp. 405-410 ◽  
Author(s):  
Moo-Yong Rhee ◽  
Sung-Joon Shin ◽  
Namyi Gu ◽  
Deuk-Young Nah ◽  
Byong-Kyu Kim ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Urine Sodium ◽  
Sodium Potassium ◽  
Hypertensive Patients

Paradoxical Hypotension during Dobutamine Infusion for Myocardial Perfusion Scintigraphy

1998 ◽  
Vol 37 (08) ◽  
pp. 268-271
Author(s):  
B. Caner ◽  
E. Atalar ◽  
A. Karanfil ◽  
L. Tokgözoğlu ◽  
E. L. Ergün
Keyword(s):  
Blood Pressure ◽  
Myocardial Perfusion ◽  
Systolic Blood Pressure ◽  
Myocardial Perfusion Scintigraphy ◽  
Stress Test ◽  
Dobutamine Infusion ◽  
Perfusion Scintigraphy ◽  
Tilt Table ◽  
Study Results ◽  
Group A

Summary Aim: Dobutamine as a predominant beta-1 agonist increases heart rate and myocardial contractility and at sufficient high doses, it also increases systolic blood pressure. This study was undertaken to describe instances of paradoxical hypotension during dobutamine infusion for TI-201 myocardial perfusion SPECT study and the relationship between scintigraphic findings and hypotension occurred during dobutamine infusion. Methods: In 201 consecutive patients unable to perform adequate exercise, dobutamine TI-201 myocardial SPECT was performed. Dobutamine was infused starting from 10 μg/kg/min increasing to 40 μg/kg/min. Paradoxical hypotension was defined as a decrease in systolic blood pressure ≥ 20 mmHg compared with baseline study. Results: Paradoxical hypotension was observed in 40 patients (Group A) out of 201 (19.9%) while no significant change in systolic blood pressure was detected in the remaining 161 patients (Group B). Mean maximum fall in systolic blood pressure was 39 ± 18 mmHg (range: 20-90). In 33 of 40 patients (83%) with paradoxical hypotension, scintigraphy was normal compared to 131 (81%) of the remaining 161 patients. In patients of Group A, angiography, echocardiography and tilt table tests were performed in 13, 11 and 6 patients respectively. Nine of 13 angiographic evaluations (69%), 10 of 11 echocardiographic evaluations (91%), all of the tilt table tests were normal. Additionally, all of the patients of Group A were clinically followed up at least 6 months after the myocardial perfusion scintigraphy. None of the patients had a cardiac event except one patient during the follow-up period. Conclusion: Paradoxical hypotension during dobutamine infusion for myocardial scintigraphy is not an uncommon finding and up to 19.9% patients may develop such hypotension. To maximize test safety, precautions should be taken during dobutamine myocardial stress test, since remarkable decrease in systolic blood pressure may occur. Unlike hypotension occurring with exercise test, hypotension response to dobutamine is not always a marker for coronary artery disease.

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