Effect of Aspirin on Urinary Excretion of 6-Ketoprostaglandin F1α

1983 ◽  
Vol 64 (4) ◽  
pp. 395-398 ◽  
Author(s):  
P. B. B. Jones ◽  
R. G. G. Russell
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Acetylsalicylic Acid ◽  
Vascular Tissue ◽  
Excretion Rate ◽  
Human Subjects ◽  
Normal Human ◽  
High Doses ◽  
Prostacyclin Production

1. We studied the effect of oral administration of acetylsalicylic acid (1200 mg/day for 3 days) on the urinary excretion of 6-ketoprostaglandin F1α in normal human subjects as an index of prostacyclin production in vivo. 2. The concentrations and excretion rate in urine fell to 45% of pretreatment levels in 3 days, but returned to pretreatment values after 7 days. 3. These results suggest that production of prostacyclin in vivo is only partially inhibited by high doses of aspirin and that there are sites of production of prostacyclin which are protected from inhibition by aspirin and which contribute to urinary 6-ketoprostaglandin F1α. The measurement of 6-ketoprostaglandin F1α in urine may therefore be of only limited value as an index of the metabolism of vascular tissue in vivo.

THE URINARY EXCRETION OF PENICILLIN AFTER ORAL ADMINISTRATION TO NORMAL HUMAN SUBJECTS

Science ◽  
1944 ◽  
Vol 100 (2602) ◽  
pp. 431-432 ◽  
Author(s):  
A. H. FREE ◽  
J. R. LEONARDS ◽  
D. R. MCCULLAGH ◽  
B. E. BIRO
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Human Subjects ◽  
Normal Human

Direct Proportionality of Urinary Excretion Rate and Serum Level of Tetracycline in Human Subjects

Nature ◽  
1963 ◽  
Vol 198 (4879) ◽  
pp. 450-453 ◽  
Author(s):  
T. CHULSKI ◽  
R. H. JOHNSON ◽  
C. A. SCHLAGEL ◽  
J. G. WAGNER
Keyword(s):  
Serum Level ◽  
Urinary Excretion ◽  
Excretion Rate ◽  
Human Subjects ◽  
Urinary Excretion Rate ◽  
Direct Proportionality

Comparison of the feedback effect of magnesium and calcium on parathyroid hormone secretion in man

1987 ◽  
Vol 113 (1) ◽  
pp. 117-122 ◽  
Author(s):  
O. Ferment ◽  
P. E. Garnier ◽  
Y. Touitou
Keyword(s):  
Parathyroid Hormone ◽  
Urinary Excretion ◽  
Hormone Secretion ◽  
Plasma Concentrations ◽  
Magnesium Salt ◽  
Saline Injection ◽  
Molar Basis ◽  
Magnesium Salts ◽  
High Doses

ABSTRACT Administration of high doses of magnesium is known to produce a decrease in parathyroid hormone (PTH) secretion in human patients but the effect of magnesium on the secretion of PTH in healthy man is not known. We have looked at the effect of a relatively moderate i.v. dose of magnesium (7·08 mmol) in seven healthy men. In addition and for comparison the effect of calcium (4·25 mmol) was studied. Two magnesium salts were considered, magnesium sulphate (MgSO4) and magnesium pyrrolidone carboxylate (MgPC). Four i.v. injections were given at 08.00 h (MgPC, NaCl (control), MgSO4 and Ca gluconate), with an interval of 1 week between each injection. Whatever the magnesium salt the variations in plasma concentrations of magnesium were the same whereas no change in erythrocyte magnesium was observed. Plasma concentration of C-terminal PTH did not show significant variations after MgPC or saline injection. Both MgSO4 and Ca gluconate produced a statistically significant 30% decrease in plasma PTH levels 45 min after the injection. The effect was more sustained with calcium (2 h) than with magnesium (45 min). The urinary excretion of magnesium was significantly higher after injection of MgSO4 than after MgPC. These results suggest (1) that magnesium was, on a molar basis, less potent than calcium in regulating PTH secretion in vivo, (2) that the nature of the magnesium salt used must be kept in mind for the interpretation of the effect of magnesium on PTH secretion in vivo and (3) that the decrease in plasma PTH can partly explain the larger urinary excretion of magnesium after MgSO4 than after MgPC. J. Endocr. (1987) 113, 117–122

scholarly journals Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose: Evidence for an Inhibitory Effect on Short-Chain Fatty Acid Metabolism

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Catharina M. C. Mels ◽  
Peet Jansen van Rensburg ◽  
Francois H. van der Westhuizen ◽  
Pieter J. Pretorius ◽  
Elardus Erasmus
Keyword(s):  
Fatty Acid ◽  
Acetylsalicylic Acid ◽  
Fatty Acid Metabolism ◽  
Short Chain Fatty Acid ◽  
Acid Metabolism ◽  
Human Subjects ◽  
Inhibitory Effect ◽  
Chain Fatty Acid ◽  
Short Chain

Acetylsalicylic acid and/or its metabolites are implicated to have various effects on metabolism and, especially, on mitochondrial function. These effects include both inhibitory and stimulatory effects. We investigated the effect of both combined and separate oral acetylsalicylic acid and acetaminophen administration at therapeutic doses on the urinary metabolite profile of human subjects. In this paper, we provided in vivo evidence, in human subjects, of a statistically significant increase in isobutyrylcarnitine after the administration of a therapeutic dose of acetylsalicylic acid. We, therefore, propose an inhibitory effect of acetylsalicylic acid on the short-chain fatty acid metabolism, possibly at the level of isobutyryl-CoA dehydrogenase.

Bronchoprotective and bronchodilatory effects of deep inspiration in rabbits subjected to bronchial challenge

2001 ◽  
Vol 91 (6) ◽  
pp. 2511-2516 ◽  
Author(s):  
S. J. Gunst ◽  
X. Shen ◽  
R. Ramchandani ◽  
R. S. Tepper
Keyword(s):  
Human Subjects ◽  
Inhibitory Effect ◽  
Airway Responsiveness ◽  
Deep Inspiration ◽  
Contractile Apparatus ◽  
Airway Reactivity ◽  
Airway Response ◽  
Normal Human ◽  
Airway Responses

The effect of deep inspiration (DI) on airway responsiveness differs in asthmatic and normal human subjects. The mechanism for the effects of DI on airway responsiveness in vivo has not been identified. To elucidate potential mechanisms, we compared the effects of DI imposed before or during induced bronchoconstriction on the airway response to methacholine (MCh) in rabbits. The changes in airway resistance in response to intravenous MCh were continuously monitored. DI depressed the maximum response to MCh when imposed before or during the MCh challenge; however, the inhibitory effect of DI was greater when imposed during bronchoconstriction. Because immature rabbits have greater airway reactivity than mature rabbits, we compared the effects of DI on their airway responses. No differences were observed. Our results suggest that the mechanisms by which DI inhibits airway responsiveness do not depend on prior activation of airway smooth muscle (ASM). These results are consistent with the possibility that reorganization of the contractile apparatus caused by stretch of ASM during DI contributes to depression of the airway response.

Platelet catecholamines and platelet function in normal human subjects

1987 ◽  
Vol 73 (1) ◽  
pp. 99-103 ◽  
Author(s):  
A. P. Wilson ◽  
C. C. T. Smith ◽  
B. N. C. Prichard ◽  
D. J. Betteridge
Keyword(s):  
Platelet Function ◽  
High Performance ◽  
Human Subjects ◽  
Normal Subjects ◽  
Noradrenaline Content ◽  
Collagen Concentration ◽  
Normal Human ◽  
Wall Interaction ◽  
Local Release

1. We have used high-performance liquid chromatography with electrochemical detection to measure plasma and platelet catecholamines in 24 normal subjects. 2. In the same subjects platelet function was assessed by measuring platelet aggregation in response to adenosine 5′-pyrophosphate, thrombin, adrenaline and collagen. Platelet sensitivity to prostacyclin was also examined. 3. Platelet noradrenaline showed a positive correlation with extent of aggregation induced by ‘low-dose’ collagen (1 μg/ml). No correlation was seen at the higher collagen concentration. 4. Platelet noradrenaline content also correlated with sensitivity of platelets to prostacyclin. High platelet noradrenaline concentrations appeared to result in decreased sensitivity to prostacyclin. 5. No other correlations were observed. 6. These data suggest that platelet noradrenaline rather than plasma levels may be involved in modifying platelet function in vivo. Local release of platelet catecholamines may affect the platelet/vessel wall interaction, the primary physiological step in platelet activation.

Plasma levels and urinary excretion of hexamethylmelamine following oral administration to human subjects with cancer

1968 ◽  
Vol 9 (6) ◽  
pp. 777-782 ◽  
Author(s):  
George T. Bryan ◽  
John F. Worzalla ◽  
Arnold L. Gorske ◽  
G. Ramirez
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Plasma Levels ◽  
Human Subjects

PAROTID SECRETION OF IODIDE

1956 ◽  
Vol 34 (4) ◽  
pp. 683-688 ◽  
Author(s):  
Marion H. Ferguson ◽  
A. Naimark ◽  
J. A. Hildes
Keyword(s):  
Thyroid Gland ◽  
Oral Administration ◽  
Blood Level ◽  
Potassium Iodide ◽  
Human Subjects ◽  
Ammonium Thiocyanate ◽  
Curvilinear Relationship ◽  
Parotid Glands ◽  
Flow Rates ◽  
Normal Human

Parotid juice from normal human subjects was collected by means of suction cups over the parotid papillae. The iodide content of the secretion was determined at various flow rates with and without the oral administration of potassium iodide, ammonium thiocyanate, and methimazole (Tapazole, Lilly), as these drugs are known to influence iodide metabolism in the thyroid gland. An inverse curvilinear relationship was found between the concentration of iodide and the rate of parotid secretion. Potassium iodide by mouth increased the concentration of parotid juice iodide in the same proportion as the increase in blood level of iodide. The amount of iodide secreted by the parotid glands was depressed by the administration of thiocyanate but was not influenced by the administration of methimazole.

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