PAROTID SECRETION OF IODIDE

1956 ◽  
Vol 34 (4) ◽  
pp. 683-688 ◽  
Author(s):  
Marion H. Ferguson ◽  
A. Naimark ◽  
J. A. Hildes
Keyword(s):  
Thyroid Gland ◽  
Oral Administration ◽  
Blood Level ◽  
Potassium Iodide ◽  
Human Subjects ◽  
Ammonium Thiocyanate ◽  
Curvilinear Relationship ◽  
Parotid Glands ◽  
Flow Rates ◽  
Normal Human

Parotid juice from normal human subjects was collected by means of suction cups over the parotid papillae. The iodide content of the secretion was determined at various flow rates with and without the oral administration of potassium iodide, ammonium thiocyanate, and methimazole (Tapazole, Lilly), as these drugs are known to influence iodide metabolism in the thyroid gland. An inverse curvilinear relationship was found between the concentration of iodide and the rate of parotid secretion. Potassium iodide by mouth increased the concentration of parotid juice iodide in the same proportion as the increase in blood level of iodide. The amount of iodide secreted by the parotid glands was depressed by the administration of thiocyanate but was not influenced by the administration of methimazole.

PAROTID SECRETION OF IODIDE

1956 ◽  
Vol 34 (1) ◽  
pp. 683-688 ◽  
Author(s):  
Marion H. Ferguson ◽  
A. Naimark ◽  
J. A. Hildes
Keyword(s):  
Thyroid Gland ◽  
Oral Administration ◽  
Blood Level ◽  
Potassium Iodide ◽  
Human Subjects ◽  
Ammonium Thiocyanate ◽  
Curvilinear Relationship ◽  
Parotid Glands ◽  
Flow Rates ◽  
Normal Human

Parotid juice from normal human subjects was collected by means of suction cups over the parotid papillae. The iodide content of the secretion was determined at various flow rates with and without the oral administration of potassium iodide, ammonium thiocyanate, and methimazole (Tapazole, Lilly), as these drugs are known to influence iodide metabolism in the thyroid gland. An inverse curvilinear relationship was found between the concentration of iodide and the rate of parotid secretion. Potassium iodide by mouth increased the concentration of parotid juice iodide in the same proportion as the increase in blood level of iodide. The amount of iodide secreted by the parotid glands was depressed by the administration of thiocyanate but was not influenced by the administration of methimazole.

The Effect of Bromocriptine on Circulating Vasopressin

1982 ◽  
Vol 63 (4) ◽  
pp. 367-372 ◽  
Author(s):  
Bruce G. Robinson ◽  
Phillip Clifton-Bligh ◽  
Solomon Posen ◽  
Brian J. Morris
Keyword(s):  
Oral Administration ◽  
Arginine Vasopressin ◽  
Human Subjects ◽  
Normal Human ◽  
Plasma Arginine ◽  
Dopaminergic Control

1. The oral administration of 2·5 mg of the dopamine (3,4-dihydroxyphenethylamine) agonist bromoergocriptine enhanced the osmotically stimulated rise in plasma [arginine]vasopressin ([Arg]VP) concentrations in five normal human subjects. 2. This finding lends support to the suggestion that the osmotically induced release of [Arg]VP is under dopaminergic control in man.

THE URINARY EXCRETION OF PENICILLIN AFTER ORAL ADMINISTRATION TO NORMAL HUMAN SUBJECTS

Science ◽  
1944 ◽  
Vol 100 (2602) ◽  
pp. 431-432 ◽  
Author(s):  
A. H. FREE ◽  
J. R. LEONARDS ◽  
D. R. MCCULLAGH ◽  
B. E. BIRO
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Human Subjects ◽  
Normal Human

Posterior cricoarytenoid activity and glottic size during hyperpnea in humans

1991 ◽  
Vol 71 (3) ◽  
pp. 977-982 ◽  
Author(s):  
A. Brancatisano ◽  
D. S. Dodd ◽  
L. A. Engel
Keyword(s):  
Human Subjects ◽  
Curvilinear Relationship ◽  
Electromyographic Activity ◽  
Forced Expiration ◽  
Mechanical Coupling ◽  
Agonist And Antagonist ◽  
Normal Human ◽  
Posterior Cricoarytenoid ◽  
Relationship Of ◽  
Forced Expiratory Maneuver

We measured the electromyographic activity of the posterior cricoarytenoid (PCA) muscle simultaneously with glottic width (dg) in five normal human subjects during hyperpnea induced by hypoxia (7% CO2 in N2) or hypercapnia (9% CO2 in 50% O2). The glottic aperture was measured during inspiration at the time corresponding to peak inspiratory PCA activity and during expiration at the time corresponding to the minimum tonic activity. During hyperpnea, peak and tonic PCA activity increased simultaneously with widening of the vocal cords in both phases of the respiratory cycle. The PCA activity during both inspiration and expiration showed a single curvilinear relationship with dg of the form dg = A - Be-k.PCA (where A, B, and k are constants) in three of the five subjects. At 50% of maximum PCA activity, dg already reached 95% of its maximum value, which was less than that recorded during a voluntary forced expiratory maneuver. The single curvilinear relationship between PCA activity and dg could be due to the length-tension relationship of the PCA muscle and/or changes in its mechanical coupling, as well as simultaneous agonist and antagonist laryngeal muscle activity during progressive chemical stimulation. Also, further widening of the glottis during forced expiration suggests recruitment of additional muscles, e.g., the arytenoideus.

Effect of Aspirin on Urinary Excretion of 6-Ketoprostaglandin F1α

1983 ◽  
Vol 64 (4) ◽  
pp. 395-398 ◽  
Author(s):  
P. B. B. Jones ◽  
R. G. G. Russell
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Acetylsalicylic Acid ◽  
Vascular Tissue ◽  
Excretion Rate ◽  
Human Subjects ◽  
Normal Human ◽  
High Doses ◽  
Prostacyclin Production

1. We studied the effect of oral administration of acetylsalicylic acid (1200 mg/day for 3 days) on the urinary excretion of 6-ketoprostaglandin F1α in normal human subjects as an index of prostacyclin production in vivo. 2. The concentrations and excretion rate in urine fell to 45% of pretreatment levels in 3 days, but returned to pretreatment values after 7 days. 3. These results suggest that production of prostacyclin in vivo is only partially inhibited by high doses of aspirin and that there are sites of production of prostacyclin which are protected from inhibition by aspirin and which contribute to urinary 6-ketoprostaglandin F1α. The measurement of 6-ketoprostaglandin F1α in urine may therefore be of only limited value as an index of the metabolism of vascular tissue in vivo.

Observations on a Relationship between Steroid Metabolism and the Concentration of Plasma Fibrinogen

1963 ◽  
Vol 10 (02) ◽  
pp. 400-405 ◽  
Author(s):  
B. A Amundson ◽  
L. O Pilgeram
Keyword(s):  
Blood Coagulation ◽  
Methyl Ether ◽  
Broad Spectrum ◽  
Human Subjects ◽  
Plasma Fibrinogen ◽  
Steroid Metabolism ◽  
Specific Site ◽  
Chain Reaction ◽  
Normal Human ◽  
A Chain

SummaryEnovid (5 mg norethynodrel and 0.075 mg ethynylestradiol-3-methyl ether) therapy in young normal human subjects causes an increase in plasma fibrinogen of 32.4% (P >C 0.001). Consideration of this effect together with other effects of Enovid on the activity of specific blood coagulatory factors suggests that the steroids are exerting their effect at a specific site of the blood coagulation and/or fibrinolytic system. The broad spectrum of changes which are induced by the steroids may be attributed to a combination of a chain reaction and feed-back control.

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