Plasma levels and urinary excretion of hexamethylmelamine following oral administration to human subjects with cancer

1968 ◽  
Vol 9 (6) ◽  
pp. 777-782 ◽  
Author(s):  
George T. Bryan ◽  
John F. Worzalla ◽  
Arnold L. Gorske ◽  
G. Ramirez
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Plasma Levels ◽  
Human Subjects

THE URINARY EXCRETION OF PENICILLIN AFTER ORAL ADMINISTRATION TO NORMAL HUMAN SUBJECTS

Science ◽  
1944 ◽  
Vol 100 (2602) ◽  
pp. 431-432 ◽  
Author(s):  
A. H. FREE ◽  
J. R. LEONARDS ◽  
D. R. MCCULLAGH ◽  
B. E. BIRO
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Human Subjects ◽  
Normal Human

Circadian variation in urinary excretion of ciprofloxacin after a single-dose oral administration at 1000 and 2200 hours in human subjects.

1997 ◽  
Vol 41 (8) ◽  
pp. 1802-1804 ◽  
Author(s):  
V V Rao ◽  
D Rambhau ◽  
B R Rao ◽  
P Srinivasu
Keyword(s):  
Single Dose ◽  
Oral Administration ◽  
Urinary Excretion ◽  
High Performance ◽  
Human Subjects ◽  
Circadian Variation ◽  
Healthy Human ◽  
Chromatography Method ◽  
Factors Affecting ◽  
Therapeutic Benefits

Ciprofloxacin is routinely prescribed to treat a variety of infections, including those of the urinary tract. To achieve optimum therapeutic benefits of the drug, all of the factors which influence its pharmacokinetics and effectiveness need to be determined. This study investigated the urinary excretion kinetics of ciprofloxacin upon oral administration of a single dose of 250 mg at 1000 or 2200 h in 12 healthy human subjects in a crossover design. The urine samples were analyzed for unchanged ciprofloxacin by a sensitive high-performance liquid chromatography method. A significant decrease in the rate and extent of ciprofloxacin excretion following 2200 h (109.59 versus 53.8 mg [P < 0.05]) administration was observed. This result may be due to circadian changes in the factors affecting renal excretion and also probably metabolism of ciprofloxacin.

Plasma Levels and Urinary Excretion of Iodine After Oral Administration of Iohexol in Dogs and Cats

1995 ◽  
Vol 30 (5) ◽  
pp. 296-299 ◽  
Author(s):  
AMALIA AGUT ◽  
FRANCISCO G. LAREDO ◽  
MIGUEL A. SANCHEZ-VALVERDE ◽  
JOSE MURCIANO ◽  
MARIA del CARMEN TOVAR
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Plasma Levels

Effect of Aspirin on Urinary Excretion of 6-Ketoprostaglandin F1α

1983 ◽  
Vol 64 (4) ◽  
pp. 395-398 ◽  
Author(s):  
P. B. B. Jones ◽  
R. G. G. Russell
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Acetylsalicylic Acid ◽  
Vascular Tissue ◽  
Excretion Rate ◽  
Human Subjects ◽  
Normal Human ◽  
High Doses ◽  
Prostacyclin Production

1. We studied the effect of oral administration of acetylsalicylic acid (1200 mg/day for 3 days) on the urinary excretion of 6-ketoprostaglandin F1α in normal human subjects as an index of prostacyclin production in vivo. 2. The concentrations and excretion rate in urine fell to 45% of pretreatment levels in 3 days, but returned to pretreatment values after 7 days. 3. These results suggest that production of prostacyclin in vivo is only partially inhibited by high doses of aspirin and that there are sites of production of prostacyclin which are protected from inhibition by aspirin and which contribute to urinary 6-ketoprostaglandin F1α. The measurement of 6-ketoprostaglandin F1α in urine may therefore be of only limited value as an index of the metabolism of vascular tissue in vivo.

METABOLIC STUDIES WITH METHANDROSTENOLONE (17β-HYDROXY-17α-METHYL-ANDROSTA-1,4-DIEN-3-ONE) IN HUMAN SUBJECTS

1961 ◽  
Vol 38 (3) ◽  
pp. 413-418 ◽  
Author(s):  
S. Almqvist ◽  
D. Ikkos ◽  
R. Luft
Keyword(s):  
Urinary Excretion ◽  
Testosterone Propionate ◽  
Human Subjects ◽  
Calcium Retention ◽  
Metabolic Studies ◽  
Daily Dose

ABSTRACT The effect of graded doses (5, 10 and 25 mg/d of methandrostenolone and of 25 mg/d of testosterone propionate were compared in each of three metabolically stable adult subjects. Five mg/d of methandrostenolone induced nitrogen and calcium retention. The effects observed with larger doses of methandrostenolone (10 and 25 mg/d) were not quantitatively different from those with 5 mg/d. The nitrogen and calcium retention obtained with the daily dose of 5 mg of methandrostenolone was as great or greater than that induced by testosterone propionate (25 mg/d). Methandrostenolone induced creatinuria but had no effect on sodium and chloride balances and urinary excretion of 17-ketosteroids.

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