Effects of Exogenous Parathyroid Hormone on the Renal Tubular Reabsorption of Calcium in man

1978 ◽  
Vol 55 (3) ◽  
pp. 8P-9P
Author(s):  
J. S. Woodhead ◽  
D. A. Walker ◽  
S. J. Davies ◽  
C. J. Davies
Keyword(s):  
Parathyroid Hormone ◽  
Tubular Reabsorption ◽  
Renal Tubular Reabsorption ◽  
Renal Tubular

Effect of parathyroid hormone on renal tubular reabsorption of amino acids

Metabolism ◽  
1974 ◽  
Vol 23 (8) ◽  
pp. 715-727 ◽  
Author(s):  
Elizabeth M. Short ◽  
Louis J. Elsas ◽  
Leon E. Rosenberg
Keyword(s):  
Amino Acids ◽  
Parathyroid Hormone ◽  
Tubular Reabsorption ◽  
Renal Tubular Reabsorption ◽  
Renal Tubular

INHIBITORY EFFECT OF CERTAIN AMINO ACIDS ON RENAL TUBULAR ABSORPTION OF PHOSPHATE

1967 ◽  
Vol 45 (1) ◽  
pp. 103-114 ◽  
Author(s):  
Alfred F. Michael ◽  
Keith N. Drummond
Keyword(s):  
Amino Acids ◽  
Parathyroid Hormone ◽  
Inhibitory Effect ◽  
Tubular Reabsorption ◽  
Hormone Action ◽  
Basic Amino Acids ◽  
Phosphate Excretion ◽  
Renal Tubular Reabsorption ◽  
Tubular Absorption ◽  
Renal Tubular

Infusion of certain neutral L-amino acids (alanine, glycine, valine, and tryptophan) into dogs resulted in an inhibition of the renal tubular reabsorption of phosphate and increased phosphate excretion. This was seen in both the parathyroidectomized animal and under conditions of exogenous parathormone infusion, indicating that the phosphaturia induced by amino acids is independent of parathyroid hormone action. This effect was stereospecific and did not occur with D-alanine; no effect was observed after infusion of the basic amino acids L-arginine and L-lysine.

PARATHYROID FUNCTION IN SPONTANEOUS PRIMARY HYPOTHYROIDISM

1968 ◽  
Vol 40 (4) ◽  
pp. 467-475 ◽  
Author(s):  
P. ADAMS ◽  
T. M. CHALMERS ◽  
B. L. RIGGS ◽  
J. D. JONES
Keyword(s):  
Parathyroid Hormone ◽  
Hormone Secretion ◽  
Primary Hypothyroidism ◽  
Tubular Reabsorption ◽  
Target Cells ◽  
Serum Calcium Concentration ◽  
Parathyroid Function ◽  
Renal Tubular Reabsorption ◽  
The Mean ◽  
Renal Tubular

SUMMARY Calcium and phosphorus metabolism were studied in 22 patients with spontaneous primary hypothyroidism. Two patients were found to have hypercalcaemia but the mean serum calcium concentration of the group was significantly less than that of control subjects. The renal tubular reabsorption of phosphate was decreased and could be increased to normal with small calcium infusions. The response to calcium deprivation and to infusions of EDTA was abnormal and suggested an impaired ability to mobilize calcium from bone. There was a significant correlation between the defect in calcium mobilization, as judged from the response to EDTA, and the renal tubular reabsorption of phosphate. In three patients serum parathyroid hormone concentrations, measured by radioimmunoassay, were in the upper part of the normal range. It is suggested that in patients with hypothyroidism the target cells in bone are less responsive to the effects of parathyroid hormone than normal; as a consequence parathyroid hormone secretion may be increased.

Effects of Parathyroid Hormone on Sodium and Calcium Transport in the Dog Nephron

1976 ◽  
Vol 51 (4) ◽  
pp. 345-351 ◽  
Author(s):  
R. A. L. Sutton ◽  
N. L. M. Wong ◽  
J. H. Dirks
Keyword(s):  
Parathyroid Hormone ◽  
Calcium Transport ◽  
Distal Tubule ◽  
Tubular Reabsorption ◽  
Puncture Site ◽  
Calcium Reabsorption ◽  
Renal Tubular Reabsorption ◽  
Renal Tubular ◽  
Selective Enhancement ◽  
Bovine Parathyroid Hormone

1. The effect of purified bovine parathyroid hormone on renal tubular reabsorption of sodium and calcium has been studied by micropuncture in intact and recently thyroparathyroidectomized dogs. 2. Parathyroid hormone increased the rejection of sodium and calcium proportionately at the late proximal tubule in both intact and operated dogs. 3. In both groups of dogs, there was increased delivery of sodium and calcium to the distal tubule after the hormone. However, the Ca/Na ratio decreased, suggesting some selective enhancement of calcium reabsorption before the superficial distal puncture site. 4. In the final urine, the Ca/Na ratio decreased highly significantly in both groups of dogs, indicating a further selective effect of parathyroid hormone on calcium reabsorption in or beyond the distal convoluted tubule.

Diphosphonates and phosphate homoeostasis in man

1988 ◽  
Vol 74 (6) ◽  
pp. 607-612 ◽  
Author(s):  
E. V. McCloskey ◽  
A. J. P. Yates ◽  
R. E. S. Gray ◽  
N. A. T. Hamdy ◽  
J. Galloway ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Urinary Calcium ◽  
Tubular Reabsorption ◽  
Serum Phosphate ◽  
Paget's Disease Of Bone ◽  
Renal Tubular Reabsorption ◽  
Renal Tubular

1. The effects of three intravenous diphosphonates (etidronate, clodronate and aminohexane diphosphonate) on phosphate homoeostasis were studied in 30 patients with Paget's disease of bone and in three patients with hypoparathyroidism. 2. In Paget's disease, all three diphosphonates induced significant increases in serum phosphate and renal tubular reabsorption of phosphate. This effect was most marked and persistent after etidronate, whereas in the clodronate- and aminohexane diphosphonate-treated patients the increases were less, of shorter duration and followed thereafter by significant decreases in serum phosphate and renal tubular reabsorption of phosphate. Unlike etidronate, both clodronate and aminohexane diphosphonate caused a significant reduction in serum and urinary calcium, with appropriate homoeostatic increases in immunoassayable parathyroid hormone. 3. Phosphaturic responses to infused parathyroid hormone were observed in two patients with etidronate-induced hyperphosphataemia. 4. In three hypoparathyroid patients, clodronate induced a more marked increase in serum phosphate and renal tubular reabsorption of phosphate than in Paget‘s disease, which was of comparable degree but of shorter duration than that after etidronate in Paget's disease. 5. These findings suggest that all three diphosphonates increase renal tubular reabsorption of phosphate, but that this effect is attenuated with those diphosphonates which induce secondary hyperparathyroidism.

The mechanism of hypocalcaemia following thyroidectomy

1985 ◽  
Vol 109 (2) ◽  
pp. 220-226 ◽  
Author(s):  
Richard C. Percival ◽  
Arthur W. Hargreaves ◽  
John A. Kanis
Keyword(s):  
Parathyroid Hormone ◽  
Thyroid Surgery ◽  
Tubular Reabsorption ◽  
Renal Tubular Reabsorption ◽  
Partial Thyroidectomy ◽  
Renal Tubular

Abstract. The mechanism of transient hypocalcaemia following thyroidectomy was studied in 29 consecutive patients undergoing thyroid surgery. Eight of 27 (30%) patients who had a partial thyroidectomy developed transient hypocalcaemia. Hypocalcaemia was attributable to a reduction in renal tubular reabsorption of calcium (P < 0.05), but was not associated with changes in serum values of immunoassayable parathyroid hormone or calcitonin.

scholarly journals Early post-transplantation hypophosphatemia is associated with elevated FGF-23 levels

2011 ◽  
Vol 164 (5) ◽  
pp. 839-847 ◽  
Author(s):  
Andrea Trombetti ◽  
Laura Richert ◽  
Karine Hadaya ◽  
Jean-Daniel Graf ◽  
François R Herrmann ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Tubular Reabsorption ◽  
Phosphate Metabolism ◽  
Multivariate Models ◽  
Intact Pth ◽  
Post Transplantation ◽  
Estimated Gfr ◽  
Renal Tubular Reabsorption ◽  
Renal Tubular ◽  
Fgf 23

BackgroundWe examined the hypothesis that high FGF-23 levels early after transplantation contribute to the onset of hypophosphatemia, independently of parathyroid hormone (PTH) and other factors regulating phosphate metabolism.MethodsWe measured serum phosphate levels (sPi), renal tubular reabsorption of Pi (TmPi/GFR), estimated GFR (eGFR), intact PTH (iPTH), calcitriol, intact (int) and C-terminal (Cter) FGF-23, dietary Pi intake and cumulative doses of glucocorticoids in 69 patients 12 days (95% confidence interval, 10–13) after renal transplantation.ResultsHypophosphatemia was observed in 43 (62%) of the patients 12 days after transplantation. Compared with non-hypophosphatemic subjects, their post-transplantation levels of intact and CterFGF-23 were higher (195 (108–288) vs 48 (40–64) ng/l, P<0.002 for intFGF-23; 205 (116–384) vs 81 (55–124) U/ml, P<0.002, for CterFGF-23). In all subjects, Cter and intFGF-23 correlated inversely with sPi (r=−0.35, P<0.003; −0.35, P<0.003, respectively), and TmPi/GFR (r=−0.50, P<0.001; −0.54, P<0.001, respectively). In multivariate models, sPi and TmPi/GFR were independently associated with FGF-23, iPTH and eGFR. Pre-transplant iPTH levels were significantly higher in patients developing hypophosphatemia after renal transplantation. Pre-transplant levels of FGF-23 were not associated with sPi at the time of transplantation.ConclusionIn addition to PTH, elevated FGF-23 may contribute to hypophosphatemia during the early post-renal transplant period.

Renal tubular reabsorption of trace alkaline earths compared with calcium

1965 ◽  
Vol 208 (6) ◽  
pp. 1165-1170 ◽  
Author(s):  
W. Joseph Rahill ◽  
Mackenzie Walser
Keyword(s):  
Protein Binding ◽  
Transport Mechanism ◽  
Tubular Reabsorption ◽  
Constant Infusion ◽  
Constant Power ◽  
Calcium Clearance ◽  
Renal Tubular Reabsorption ◽  
Order Of Magnitude ◽  
Alkaline Earths ◽  
Renal Tubular

Simultaneous clearances of inulin, calcium, and either Be7, Ba140, or Ra226, given by constant infusion, were measured in salt-depleted dogs or dogs undergoing mild saline, mannitol, or sulfate diuresis. Urine-to-plasma ratios of all three cations less than 0.5 were noted, suggesting that all can be actively reabsorbed. Clearances of barium and radium were correlated with calcium clearance, but the clearance of beryllium was unpredictable. Protein binding of beryllium was shown to be of the same order of magnitude as other alkaline earths when errors due to adsorption of Be7 onto containers were minimized. Protein binding of barium averaged 54%. The excreted-to-filtered ratio for barium was a constant power (.54) of the ratio for calcium. The data do not exclude the possibility that these cations are reabsorbed by a common transport mechanism with calcium.

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